High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle

• Published in: Endocrinology (Philadelphia) Vol. 154; no. 4; pp. 1444 - 1453
• Main Authors: Badin, Pierre-Marie, Vila, Isabelle K., Louche, Katie, Mairal, Aline, Marques, Marie-Adeline, Bourlier, Virginie, Tavernier, Geneviève, Langin, Dominique, Moro, Cedric
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Oxford University Press 01.04.2013; Endocrine Society
• Subjects: 1-Acylglycerol-3-Phosphate O-Acyltransferase; 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism; AKT protein; Animals; Biological and medical sciences; Carrier Proteins; Carrier Proteins - metabolism; Diet; Diet, High-Fat; Diglycerides; Diglycerides - metabolism; Endocrinology and metabolism; Fundamental and applied biological sciences. Psychology; Glucose; Glucose - metabolism; Glucose tolerance; Glucose Tolerance Test; High fat diet; Human health and pathology; In vivo methods and tests; Insulin; Insulin - metabolism; Insulin receptor substrate 1; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins - metabolism; Kinases; Life Sciences; Lipase; Lipase - metabolism; Lipids; Membrane Proteins; Membrane Proteins - metabolism; Mice; Mice, Inbred C3H; Mice, Knockout; Muscle Proteins; Muscle Proteins - metabolism; Muscle, Skeletal; Muscle, Skeletal - metabolism; Muscles; Musculoskeletal system; Perilipin-2; Perilipin-3; Phosphorylation; Protein folding; Protein kinase C; Protein transport; Proteins; Skeletal muscle; Striated muscle. Tendons; Thymoma; Translocation; Triglycerides; Vertebrates: endocrinology; Vertebrates: osteoarticular system, musculoskeletal system; Weight Gain; Endocrinopathy; Target tissue resistance; Vertebrata; Mammalia; Diet; Mouse; Animal; Rodentia; Metabolic diseases; Insulin resistance; Striated muscle; Feeding

Elevated expression/activity of adipose triglyceride lipase (ATGL) and/or reduced activity of hormone-sensitive lipase (HSL) in skeletal muscle are causally linked to insulin resistance in vitro. We investigated here the effect of high-fat feeding on skeletal muscle lipolytic proteins, lipotoxicity,...