Chronic blue light exposure induced spatial anxiety in an adolescent mouse model: Per2 upregulation and altered brain resting-state functional activity

• Published in: NeuroImage (Orlando, Fla.) Vol. 314; p. 121259
• Main Authors: Hsieh, Yu-Lin, Huang, Sheng-Min, Yu, Sebastian, Chao, Tzu-Ning, Chiang, Chia-Wen, Kan, Yu-Yu, Chang, Ying-Shuang, Kuo, Li-Wei, Yu, Hsin-Su
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2025; Elsevier Limited; Elsevier
• Subjects: Adolescents; Animal cognition; Animals; Anxiety; Anxiety - diagnostic imaging; Anxiety - etiology; Anxiety - metabolism; Anxiety - physiopathology; Blue Light; Brain - diagnostic imaging; Brain - metabolism; Brain - physiopathology; Brain - radiation effects; Brain research; Circadian rhythm; Circadian Rhythm - physiology; Circadian rhythms; Cognition; Computers; Disease Models, Animal; Function magnetic resonance imaging; Functional magnetic resonance imaging; Hippocampus - physiopathology; Hypothalamus; Light; Light - adverse effects; Lighting; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neostriatum; Neural networks; Neurobiology; Neuroimaging; Neuroplasticity; Oligodendrocytes; Period 2; Period 2 protein; Period Circadian Proteins - metabolism; Sociability; Social Behavior; Social interactions; Social novelty; Spatial anxiety; Teenagers; Up-Regulation; Taiwan; ST; Function magnetic resonance imaging; Spatial anxiety; RSC; Period 2; Cg; MRI; dHip; Sociability; BL; dMRI; vHip; MOp; fMRI; SSp; TST; ALFF; Social novelty; Thal; SL; Blue light; OFT; RO

•Long-term blue light exposure to mice lead to spatial anxiety, which is related to Per2 upregulation.•Altered ALFF in hippocampus and retrosplenial cortex after long term blue light exposure.•The blue light induced spatial anxiety is associated with changes in brain activity. Blue light (BL) is the...