Magnetic nanosystem a tool for targeted delivery and diagnostic application: Current challenges and recent advancement
Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosyste...
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Published in | International journal of pharmaceutics: X Vol. 7; p. 100231 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Netherlands
Elsevier B.V
01.06.2024
Elsevier |
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Abstract | Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosystems could have also been used for diagnosis and treatment because of their magnetic, optical, and fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) are the most widely used magnetic nanosystems prepared by a simple process. By surface modification, researchers have recently been working on conjugating metals like silica, copper, and gold with magnetic nanosystems. This hybridization of the nanosystems modifies the structural characteristics of the nanomaterials and helps to improve their efficacy for targeted drug and gene delivery. The hybridization of metals with various nanomaterials like micelles, cubosomes, liposomes, and polymeric nanomaterials is gaining more interest due to their nanometer size range and nontoxic, biocompatible nature. Moreover, they have good injectability and higher targeting ability by accumulation at the target site by application of an external magnetic field. The present article discussed the magnetic nanosystem in more detail regarding their structure, properties, interaction with the biological system, and diagnostic applications.
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•Magnetic nanoparticles have magnetic properties ranging from 5 to 100 nm.•Magnetic nanosystems (MNs) exhibit promise in diverse biomedical applications.•A summary of MN types, classes, properties, & characterization methods is provided.•Synthesis methods and therapeutic applications of various MNs are also explored.•Magnetic vectorization of cells is a novel approach in the near future. |
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AbstractList | Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosystems could have also been used for diagnosis and treatment because of their magnetic, optical, and fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) are the most widely used magnetic nanosystems prepared by a simple process. By surface modification, researchers have recently been working on conjugating metals like silica, copper, and gold with magnetic nanosystems. This hybridization of the nanosystems modifies the structural characteristics of the nanomaterials and helps to improve their efficacy for targeted drug and gene delivery. The hybridization of metals with various nanomaterials like micelles, cubosomes, liposomes, and polymeric nanomaterials is gaining more interest due to their nanometer size range and nontoxic, biocompatible nature. Moreover, they have good injectability and higher targeting ability by accumulation at the target site by application of an external magnetic field. The present article discussed the magnetic nanosystem in more detail regarding their structure, properties, interaction with the biological system, and diagnostic applications.
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Magnetic nanoparticles have magnetic properties ranging from 5 to 100 nm.
•
Magnetic nanosystems (MNs) exhibit promise in diverse biomedical applications.
•
A summary of MN types, classes, properties, & characterization methods is provided.
•
Synthesis methods and therapeutic applications of various MNs are also explored.
•
Magnetic vectorization of cells is a novel approach in the near future. Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosystems could have also been used for diagnosis and treatment because of their magnetic, optical, and fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) are the most widely used magnetic nanosystems prepared by a simple process. By surface modification, researchers have recently been working on conjugating metals like silica, copper, and gold with magnetic nanosystems. This hybridization of the nanosystems modifies the structural characteristics of the nanomaterials and helps to improve their efficacy for targeted drug and gene delivery. The hybridization of metals with various nanomaterials like micelles, cubosomes, liposomes, and polymeric nanomaterials is gaining more interest due to their nanometer size range and nontoxic, biocompatible nature. Moreover, they have good injectability and higher targeting ability by accumulation at the target site by application of an external magnetic field. The present article discussed the magnetic nanosystem in more detail regarding their structure, properties, interaction with the biological system, and diagnostic applications. Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosystems could have also been used for diagnosis and treatment because of their magnetic, optical, and fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) are the most widely used magnetic nanosystems prepared by a simple process. By surface modification, researchers have recently been working on conjugating metals like silica, copper, and gold with magnetic nanosystems. This hybridization of the nanosystems modifies the structural characteristics of the nanomaterials and helps to improve their efficacy for targeted drug and gene delivery. The hybridization of metals with various nanomaterials like micelles, cubosomes, liposomes, and polymeric nanomaterials is gaining more interest due to their nanometer size range and nontoxic, biocompatible nature. Moreover, they have good injectability and higher targeting ability by accumulation at the target site by application of an external magnetic field. The present article discussed the magnetic nanosystem in more detail regarding their structure, properties, interaction with the biological system, and diagnostic applications. [Display omitted] •Magnetic nanoparticles have magnetic properties ranging from 5 to 100 nm.•Magnetic nanosystems (MNs) exhibit promise in diverse biomedical applications.•A summary of MN types, classes, properties, & characterization methods is provided.•Synthesis methods and therapeutic applications of various MNs are also explored.•Magnetic vectorization of cells is a novel approach in the near future. Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosystems could have also been used for diagnosis and treatment because of their magnetic, optical, and fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) are the most widely used magnetic nanosystems prepared by a simple process. By surface modification, researchers have recently been working on conjugating metals like silica, copper, and gold with magnetic nanosystems. This hybridization of the nanosystems modifies the structural characteristics of the nanomaterials and helps to improve their efficacy for targeted drug and gene delivery. The hybridization of metals with various nanomaterials like micelles, cubosomes, liposomes, and polymeric nanomaterials is gaining more interest due to their nanometer size range and nontoxic, biocompatible nature. Moreover, they have good injectability and higher targeting ability by accumulation at the target site by application of an external magnetic field. The present article discussed the magnetic nanosystem in more detail regarding their structure, properties, interaction with the biological system, and diagnostic applications.Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosystems could have also been used for diagnosis and treatment because of their magnetic, optical, and fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) are the most widely used magnetic nanosystems prepared by a simple process. By surface modification, researchers have recently been working on conjugating metals like silica, copper, and gold with magnetic nanosystems. This hybridization of the nanosystems modifies the structural characteristics of the nanomaterials and helps to improve their efficacy for targeted drug and gene delivery. The hybridization of metals with various nanomaterials like micelles, cubosomes, liposomes, and polymeric nanomaterials is gaining more interest due to their nanometer size range and nontoxic, biocompatible nature. Moreover, they have good injectability and higher targeting ability by accumulation at the target site by application of an external magnetic field. The present article discussed the magnetic nanosystem in more detail regarding their structure, properties, interaction with the biological system, and diagnostic applications. |
ArticleNumber | 100231 |
Author | Wong, Ling Shing Khedekar, Pramod Saoji, Suprit Kumarasamy, Vinoth Yadav, Sakshi Subramaniyan, Vetriselvan Rarokar, Nilesh Bramhe, Pratiksha Agade, Rishabh Gurav, Shailendra |
Author_xml | – sequence: 1 givenname: Nilesh surname: Rarokar fullname: Rarokar, Nilesh email: nileshrarokar@outlook.com organization: Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra 440033, India – sequence: 2 givenname: Sakshi surname: Yadav fullname: Yadav, Sakshi organization: Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra 440033, India – sequence: 3 givenname: Suprit surname: Saoji fullname: Saoji, Suprit organization: Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra 440033, India – sequence: 4 givenname: Pratiksha surname: Bramhe fullname: Bramhe, Pratiksha organization: Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra 440033, India – sequence: 5 givenname: Rishabh surname: Agade fullname: Agade, Rishabh organization: Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra 440033, India – sequence: 6 givenname: Shailendra surname: Gurav fullname: Gurav, Shailendra organization: Department of Pharmacognosy, Goa College of Pharmacy, Panaji, Goa University, Goa 403 001, India – sequence: 7 givenname: Pramod surname: Khedekar fullname: Khedekar, Pramod organization: Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra 440033, India – sequence: 8 givenname: Vetriselvan surname: Subramaniyan fullname: Subramaniyan, Vetriselvan organization: Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, MONASH University, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia – sequence: 9 givenname: Ling Shing surname: Wong fullname: Wong, Ling Shing organization: Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia – sequence: 10 givenname: Vinoth surname: Kumarasamy fullname: Kumarasamy, Vinoth organization: Department of Parasitology, Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38322276$$D View this record in MEDLINE/PubMed |
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