Evaluation of cytotoxic and apoptotic effects of the extracts and phenolic compounds of Astragalus globosus Vahl and Astragalus breviflorus DC
Astragalus L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. Astragalus species have been used in traditional medicine for many years. Astragalus globosus Vahl, known as “top geven”, is a dwarf, scapose, perennial herb, Astrag...
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| Published in | Saudi pharmaceutical journal Vol. 31; no. 8; p. 101682 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Saudi Arabia
Elsevier B.V
01.08.2023
Elsevier |
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| Abstract | Astragalus L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. Astragalus species have been used in traditional medicine for many years. Astragalus globosus Vahl, known as “top geven”, is a dwarf, scapose, perennial herb, Astragalus breviflorus DC., known as “yünlü geven”, is an extremely spiny dwarf shrub. These endemic species grow in the Turkish cities of Erzurum, Kars, and Van. This is the first phytochemical and cytotoxic investigation of Astragalus globosus Vahl and Astragalus breviflorus DC. The main extracts and sub-fractions from the plants were evaluated for in vitro cytotoxic and apoptotic activities. The IC50 values of dichloromethane, n-butanol, and water extracts of the aerial parts of A. globosus against the MCF-7 cell line were determined as 28.39, 868.60, and 1753.00 µg/mL. The values for the MDA-MB-231 cell line were 264.00, 620.30, and 1300.50 µg/mL, respectively. From A. globosus, the following were isolated: a flavone glycoside, diosmetin-7-O-rutinoside (1); and two flavonol glycosides, isorhamnetin-3-O-rutinoside (2) and quercetin-3-O-galactoside (3). From A. breviflorus, two phenolic acids, caffeic acid (4) and chlorogenic acid (5), and a flavan-3-ol, catechin (6), were isolated. Diosmetin-7-O-rutinoside was isolated from Astragalus species for the first time and showed the highest cytotoxic activities on the MCF-7 and MDA-MB-231 breast cancer cell lines with IC50 values of 13.65 and 12.89 μg/mL, respectively. Moreover, we observed that diosmin exerts cytotoxic effects by causing cell necrosis. |
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| AbstractList | Astragalus L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. Astragalus species have been used in traditional medicine for many years. Astragalus globosus Vahl, known as “top geven”, is a dwarf, scapose, perennial herb, Astragalus breviflorus DC., known as “yünlü geven”, is an extremely spiny dwarf shrub. These endemic species grow in the Turkish cities of Erzurum, Kars, and Van. This is the first phytochemical and cytotoxic investigation of Astragalus globosus Vahl and Astragalus breviflorus DC. The main extracts and sub-fractions from the plants were evaluated for in vitro cytotoxic and apoptotic activities. The IC50 values of dichloromethane, n-butanol, and water extracts of the aerial parts of A. globosus against the MCF-7 cell line were determined as 28.39, 868.60, and 1753.00 µg/mL. The values for the MDA-MB-231 cell line were 264.00, 620.30, and 1300.50 µg/mL, respectively. From A. globosus, the following were isolated: a flavone glycoside, diosmetin-7-O-rutinoside (1); and two flavonol glycosides, isorhamnetin-3-O-rutinoside (2) and quercetin-3-O-galactoside (3). From A. breviflorus, two phenolic acids, caffeic acid (4) and chlorogenic acid (5), and a flavan-3-ol, catechin (6), were isolated. Diosmetin-7-O-rutinoside was isolated from Astragalus species for the first time and showed the highest cytotoxic activities on the MCF-7 and MDA-MB-231 breast cancer cell lines with IC50 values of 13.65 and 12.89 μg/mL, respectively. Moreover, we observed that diosmin exerts cytotoxic effects by causing cell necrosis. Astragalus L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. Astragalus species have been used in traditional medicine for many years. Astragalus globosus Vahl, known as “top geven”, is a dwarf, scapose, perennial herb, Astragalus breviflorus DC., known as “yünlü geven”, is an extremely spiny dwarf shrub. These endemic species grow in the Turkish cities of Erzurum, Kars, and Van. This is the first phytochemical and cytotoxic investigation of Astragalus globosus Vahl and Astragalus breviflorus DC. The main extracts and sub-fractions from the plants were evaluated for in vitro cytotoxic and apoptotic activities. The IC 50 values of dichloromethane, n -butanol, and water extracts of the aerial parts of A. globosus against the MCF-7 cell line were determined as 28.39, 868.60, and 1753.00 µg/mL. The values for the MDA-MB-231 cell line were 264.00, 620.30, and 1300.50 µg/mL, respectively. From A. globosus , the following were isolated: a flavone glycoside, diosmetin-7- O -rutinoside (1); and two flavonol glycosides, isorhamnetin-3- O -rutinoside (2) and quercetin-3- O -galactoside (3). From A. breviflorus , two phenolic acids, caffeic acid (4) and chlorogenic acid (5), and a flavan-3-ol, catechin (6), were isolated. Diosmetin-7- O -rutinoside was isolated from Astragalus species for the first time and showed the highest cytotoxic activities on the MCF-7 and MDA-MB-231 breast cancer cell lines with IC 50 values of 13.65 and 12.89 μg/mL, respectively. Moreover, we observed that diosmin exerts cytotoxic effects by causing cell necrosis. L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. species have been used in traditional medicine for many years. Vahl, known as "top geven", is a dwarf, scapose, perennial herb, DC., known as "yünlü geven", is an extremely spiny dwarf shrub. These endemic species grow in the Turkish cities of Erzurum, Kars, and Van. This is the first phytochemical and cytotoxic investigation of Vahl and DC. The main extracts and sub-fractions from the plants were evaluated for cytotoxic and apoptotic activities. The IC values of dichloromethane, -butanol, and water extracts of the aerial parts of against the MCF-7 cell line were determined as 28.39, 868.60, and 1753.00 µg/mL. The values for the MDA-MB-231 cell line were 264.00, 620.30, and 1300.50 µg/mL, respectively. From , the following were isolated: a flavone glycoside, diosmetin-7- -rutinoside (1); and two flavonol glycosides, isorhamnetin-3- -rutinoside (2) and quercetin-3- -galactoside (3). From , two phenolic acids, caffeic acid (4) and chlorogenic acid (5), and a flavan-3-ol, catechin (6), were isolated. Diosmetin-7- -rutinoside was isolated from species for the first time and showed the highest cytotoxic activities on the MCF-7 and MDA-MB-231 breast cancer cell lines with IC values of 13.65 and 12.89 μg/mL, respectively. Moreover, we observed that diosmin exerts cytotoxic effects by causing cell necrosis. |
| ArticleNumber | 101682 |
| Author | Kalaycı, Benan Şimşek Özek, Nihal Özbek, Hilal Aysin, Ferhunde Kazaz, Cavit Güvenalp, Zühal Önal, Mehmet |
| Author_xml | – sequence: 1 givenname: Benan surname: Kalaycı fullname: Kalaycı, Benan email: ecz.benankalayci@gmail.com organization: Department of Pharmacognosy, Faculty of Pharmacy, Ağrı İbrahim Çeçen University, Ağrı, Turkey – sequence: 2 givenname: Nihal surname: Şimşek Özek fullname: Şimşek Özek, Nihal organization: Department of Biology, Faculty of Science, Atatürk University, Erzurum, Turkey – sequence: 3 givenname: Ferhunde surname: Aysin fullname: Aysin, Ferhunde organization: Department of Biology, Faculty of Science, Atatürk University, Erzurum, Turkey – sequence: 4 givenname: Hilal surname: Özbek fullname: Özbek, Hilal organization: Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey – sequence: 5 givenname: Cavit surname: Kazaz fullname: Kazaz, Cavit organization: Department of Chemistry, Faculty of Science, Atatürk University, Erzurum, Turkey – sequence: 6 givenname: Mehmet surname: Önal fullname: Önal, Mehmet organization: Non-wood Products Chief Engineering, Regional Directorate of Forestry, Erzurum, Turkey – sequence: 7 givenname: Zühal surname: Güvenalp fullname: Güvenalp, Zühal organization: Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum, Turkey |
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| Keywords | Astragalus globosus Vahl Breast cancer Astragalus breviflorus DC Apoptosis Cytotoxic activity |
| Language | English |
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| Snippet | Astragalus L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. Astragalus species have... L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. species have been used in... Astragalus L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. Astragalus species have... |
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| SubjectTerms | Apoptosis Astragalus breviflorus DC Astragalus globosus Vahl Breast cancer Cytotoxic activity Original |
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| Title | Evaluation of cytotoxic and apoptotic effects of the extracts and phenolic compounds of Astragalus globosus Vahl and Astragalus breviflorus DC |
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