Bromodomain inhibitors and therapeutic applications

• Published in: Current opinion in chemical biology Vol. 75; p. 102323
• Main Authors: Gajjela, Bharath Kumar, Zhou, Ming-Ming
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2023
• Subjects: BET proteins; Bromodomain; Bromodomain inhibitors; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Cycle Proteins - therapeutic use; Chromatin; Drug discovery; Gene transcription; Histones - metabolism; Humans; Neoplasms - metabolism; Nuclear Proteins - metabolism; Transcription Factors - metabolism; BET proteins; Bromodomain; Drug discovery; Bromodomain inhibitors; Gene transcription

The bromodomain acts to recognize acetylated lysine in histones and transcription proteins and plays a fundamental role in chromatin-based cellular processes including gene transcription and chromatin remodeling. Many bromodomain proteins, particularly the bromodomain and extra terminal domain (BET)...