Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants

• Published in: iScience Vol. 26; no. 10; p. 107764
• Main Authors: Gilliland, Theron, Dunn, Matthew, Liu, Yanan, Alcorn, Maria D.H., Terada, Yutaka, Vasilatos, Shauna, Lundy, Jeneveve, Li, Rong, Nambulli, Sham, Larson, Deanna, Duprex, Paul, Wu, Hua, Luke, Thomas, Bausch, Christoph, Egland, Kristi, Sullivan, Eddie, Wang, Zhongde, Klimstra, William B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.10.2023; Elsevier
• Subjects: Immune response; Immunology; Virology; Immunology; Immune response; Virology

Pandemic SARS-CoV-2 has undergone rapid evolution resulting in the emergence of many variants with mutations in the spike protein, some of which appear to evade antibody neutralization, transmit more efficiently, and/or exhibit altered virulence. This raises significant concerns regarding the effica...