Validation of dynamic [18F]FE-PE2I PET for estimation of relative regional cerebral blood flow: a comparison with [15O]H2O PET

• Published in: EJNMMI research Vol. 12; no. 1; pp. 1 - 10
• Main Authors: Jakobson Mo, Susanna, Axelsson, Jan, Stiernman, Lars, Riklund, Katrine
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 17.11.2022; Springer Nature B.V; SpringerOpen
• Subjects: 15O H2O; 18F FE-PE2; Blood flow; Brain diseases; Brain research; Cardiac Imaging; Cerebral blood flow; Cerebral perfusion; Diagnosis; Disorders; Dopamine; EUDRA-CT; EUDRA-CT 2015-003045-26; Fluorine isotopes; Glucose; Imaging; Medical imaging; Medicine; Medicine & Public Health; Metabolism; Metabolites; Neuroimaging; Nuclear Medicine; Oncology; Original Research; Orthopedics; Parkinson's disease; Parkinsonian syndromes; Parkinsonism; Positron emission; Positron emission tomography; Radioactive tracers; Radiology; Tomography; Parkinsonism; Cerebral blood flow; Cerebral perfusion; O H; F FE-PE2; Positron emission tomography; O; Parkinsonian syndromes

Background Dopamine transporter (DAT) imaging is used in the diagnostic work-up in suspected parkinsonian syndromes and dementia with Lewy bodies but cannot differentiate between these syndromes, and an extra brain imaging examination of the regional cerebral blood flow (rCBF) or glucose metabolism...