Mapping the hemodynamic response in human subjects to a dopaminergic challenge with dextroamphetamine using ASL-based pharmacological MRI

• Published in: NeuroImage (Orlando, Fla.) Vol. 72; pp. 1 - 9
• Main Authors: Schouw, M.L.J., Kaag, A.M., Caan, M.W.A., Heijtel, D.F.R., Majoie, C.B.L.M., Nederveen, A.J., Booij, J., Reneman, L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.05.2013; Elsevier; Elsevier Limited
• Subjects: ASL; Attention deficit hyperactivity disorder; Biological and medical sciences; Brain - blood supply; Brain - drug effects; Brain Mapping - methods; CBF; Central Nervous System Stimulants - pharmacology; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Dextroamphetamine; Dextroamphetamine - pharmacology; Dopamine; Dopamine - metabolism; Fundamental and applied biological sciences. Psychology; Hemodynamics; Humans; Magnetic Resonance Imaging - methods; Male; Medical imaging; phMRI; Receptors, Dopamine D2 - metabolism; Receptors, Dopamine D3 - metabolism; SPECT; Spin Labels; Studies; Tomography; Tomography, Emission-Computed, Single-Photon; Vertebrates: nervous system and sense organs; Young Adult; Dextroamphetamine; ASL; Dopamine; phMRI; CBF; SPECT; Human; Catecholamine; Nuclear magnetic resonance imaging; Photon; Neurotransmitter; Dexamfetamine; Hemodynamics; Emission tomography

Pharmacological magnetic resonance imaging (phMRI) maps the neurovascular response to a pharmacological challenge and is increasingly used to assess neurotransmitter systems. Here we investigated the hemodynamic response to a dopaminergic (DAergic) challenge with dextroamphetamine (dAMPH) in humans...