Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review

• Published in: Analytica chimica acta Vol. 891; pp. 43 - 61
• Main Authors: Li, Du-Xin, Gan, Lin, Bronja, Amela, Schmitz, Oliver J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 03.09.2015
• Subjects: analytical chemistry; Animals; Atmospheric Pressure; Atmospheric pressure chemical ionization; Atmospheric pressure ion sources; Atmospheric pressure laser ionization; Atmospheric pressure photoionization; Equipment Design; Gas chromatography – mass spectrometry; Gas Chromatography-Mass Spectrometry - instrumentation; Gas Chromatography-Mass Spectrometry - methods; geometry; Humans; ionization; Metabolomics - instrumentation; Metabolomics - methods; Spectrometry, Mass, Electrospray Ionization - instrumentation; Spectrometry, Mass, Electrospray Ionization - methods; temperature; Atmospheric pressure chemical ionization; Atmospheric pressure laser ionization; Atmospheric pressure ion sources; Atmospheric pressure photoionization; Gas chromatography – mass spectrometry

Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a “soft” ion source for preserving highly diagnostic molecular ion is desirable, as co...