Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review
Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a “soft” ion source for preserving highly diagnostic molecular ion is desirable, as co...
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Published in | Analytica chimica acta Vol. 891; pp. 43 - 61 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
03.09.2015
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Abstract | Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a “soft” ion source for preserving highly diagnostic molecular ion is desirable, as compared to the “hard” ionization technique such as electron ionization (EI) in traditional GC/MS, which fragments the molecule in an extensive way. These API sources include atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), atmospheric pressure laser ionization (APLI), electrospray ionization (ESI) and low temperature plasma (LTP). This review discusses the advantages and drawbacks of this analytical platform. After an introduction in atmospheric pressure ionization the review gives an overview about the history and explains the mechanisms of various atmospheric pressure ionization techniques used in combination with GC such as APCI, APPI, APLI, ESI and LTP. Also new developments made in ion source geometry, ion source miniaturization and multipurpose ion source constructions are discussed and a comparison between GC-FID, GC-EI-MS and GC-API-MS shows the advantages and drawbacks of these techniques. The review ends with an overview of applications realized with GC-API-MS.
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•Atmospheric pressure ion sources (APCI, ESI, APPI, APLC etc) enable the coupling of LC-based high-end MS to GC.•APIs show advantages in selectivity and sensitivity compared with EI in GC-MS.•Accurate mass database in GC-APCI/MS is emerging as an alternative to GC-EI/MS database. |
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AbstractList | Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a "soft" ion source for preserving highly diagnostic molecular ion is desirable, as compared to the "hard" ionization technique such as electron ionization (EI) in traditional GC/MS, which fragments the molecule in an extensive way. These API sources include atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), atmospheric pressure laser ionization (APLI), electrospray ionization (ESI) and low temperature plasma (LTP). This review discusses the advantages and drawbacks of this analytical platform. After an introduction in atmospheric pressure ionization the review gives an overview about the history and explains the mechanisms of various atmospheric pressure ionization techniques used in combination with GC such as APCI, APPI, APLI, ESI and LTP. Also new developments made in ion source geometry, ion source miniaturization and multipurpose ion source constructions are discussed and a comparison between GC-FID, GC-EI-MS and GC-API-MS shows the advantages and drawbacks of these techniques. The review ends with an overview of applications realized with GC-API-MS. Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a “soft” ion source for preserving highly diagnostic molecular ion is desirable, as compared to the “hard” ionization technique such as electron ionization (EI) in traditional GC/MS, which fragments the molecule in an extensive way. These API sources include atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), atmospheric pressure laser ionization (APLI), electrospray ionization (ESI) and low temperature plasma (LTP). This review discusses the advantages and drawbacks of this analytical platform. After an introduction in atmospheric pressure ionization the review gives an overview about the history and explains the mechanisms of various atmospheric pressure ionization techniques used in combination with GC such as APCI, APPI, APLI, ESI and LTP. Also new developments made in ion source geometry, ion source miniaturization and multipurpose ion source constructions are discussed and a comparison between GC-FID, GC-EI-MS and GC-API-MS shows the advantages and drawbacks of these techniques. The review ends with an overview of applications realized with GC-API-MS. [Display omitted] •Atmospheric pressure ion sources (APCI, ESI, APPI, APLC etc) enable the coupling of LC-based high-end MS to GC.•APIs show advantages in selectivity and sensitivity compared with EI in GC-MS.•Accurate mass database in GC-APCI/MS is emerging as an alternative to GC-EI/MS database. |
Author | Li, Du-Xin Gan, Lin Bronja, Amela Schmitz, Oliver J. |
Author_xml | – sequence: 1 givenname: Du-Xin orcidid: 0000-0001-5404-7048 surname: Li fullname: Li, Du-Xin – sequence: 2 givenname: Lin surname: Gan fullname: Gan, Lin – sequence: 3 givenname: Amela surname: Bronja fullname: Bronja, Amela – sequence: 4 givenname: Oliver J. surname: Schmitz fullname: Schmitz, Oliver J. email: oliver.schmitz@uni-due.de |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26388363$$D View this record in MEDLINE/PubMed |
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Keywords | Atmospheric pressure chemical ionization Atmospheric pressure laser ionization Atmospheric pressure ion sources Atmospheric pressure photoionization Gas chromatography – mass spectrometry |
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SubjectTerms | analytical chemistry Animals Atmospheric Pressure Atmospheric pressure chemical ionization Atmospheric pressure ion sources Atmospheric pressure laser ionization Atmospheric pressure photoionization Equipment Design Gas chromatography – mass spectrometry Gas Chromatography-Mass Spectrometry - instrumentation Gas Chromatography-Mass Spectrometry - methods geometry Humans ionization Metabolomics - instrumentation Metabolomics - methods Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods temperature |
Title | Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review |
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