Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review

Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a “soft” ion source for preserving highly diagnostic molecular ion is desirable, as co...

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Published inAnalytica chimica acta Vol. 891; pp. 43 - 61
Main Authors Li, Du-Xin, Gan, Lin, Bronja, Amela, Schmitz, Oliver J.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 03.09.2015
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Abstract Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a “soft” ion source for preserving highly diagnostic molecular ion is desirable, as compared to the “hard” ionization technique such as electron ionization (EI) in traditional GC/MS, which fragments the molecule in an extensive way. These API sources include atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), atmospheric pressure laser ionization (APLI), electrospray ionization (ESI) and low temperature plasma (LTP). This review discusses the advantages and drawbacks of this analytical platform. After an introduction in atmospheric pressure ionization the review gives an overview about the history and explains the mechanisms of various atmospheric pressure ionization techniques used in combination with GC such as APCI, APPI, APLI, ESI and LTP. Also new developments made in ion source geometry, ion source miniaturization and multipurpose ion source constructions are discussed and a comparison between GC-FID, GC-EI-MS and GC-API-MS shows the advantages and drawbacks of these techniques. The review ends with an overview of applications realized with GC-API-MS. [Display omitted] •Atmospheric pressure ion sources (APCI, ESI, APPI, APLC etc) enable the coupling of LC-based high-end MS to GC.•APIs show advantages in selectivity and sensitivity compared with EI in GC-MS.•Accurate mass database in GC-APCI/MS is emerging as an alternative to GC-EI/MS database.
AbstractList Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a "soft" ion source for preserving highly diagnostic molecular ion is desirable, as compared to the "hard" ionization technique such as electron ionization (EI) in traditional GC/MS, which fragments the molecule in an extensive way. These API sources include atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), atmospheric pressure laser ionization (APLI), electrospray ionization (ESI) and low temperature plasma (LTP). This review discusses the advantages and drawbacks of this analytical platform. After an introduction in atmospheric pressure ionization the review gives an overview about the history and explains the mechanisms of various atmospheric pressure ionization techniques used in combination with GC such as APCI, APPI, APLI, ESI and LTP. Also new developments made in ion source geometry, ion source miniaturization and multipurpose ion source constructions are discussed and a comparison between GC-FID, GC-EI-MS and GC-API-MS shows the advantages and drawbacks of these techniques. The review ends with an overview of applications realized with GC-API-MS.
Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion source was expanded in the last decade. The demand of a “soft” ion source for preserving highly diagnostic molecular ion is desirable, as compared to the “hard” ionization technique such as electron ionization (EI) in traditional GC/MS, which fragments the molecule in an extensive way. These API sources include atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), atmospheric pressure laser ionization (APLI), electrospray ionization (ESI) and low temperature plasma (LTP). This review discusses the advantages and drawbacks of this analytical platform. After an introduction in atmospheric pressure ionization the review gives an overview about the history and explains the mechanisms of various atmospheric pressure ionization techniques used in combination with GC such as APCI, APPI, APLI, ESI and LTP. Also new developments made in ion source geometry, ion source miniaturization and multipurpose ion source constructions are discussed and a comparison between GC-FID, GC-EI-MS and GC-API-MS shows the advantages and drawbacks of these techniques. The review ends with an overview of applications realized with GC-API-MS. [Display omitted] •Atmospheric pressure ion sources (APCI, ESI, APPI, APLC etc) enable the coupling of LC-based high-end MS to GC.•APIs show advantages in selectivity and sensitivity compared with EI in GC-MS.•Accurate mass database in GC-APCI/MS is emerging as an alternative to GC-EI/MS database.
Author Li, Du-Xin
Gan, Lin
Bronja, Amela
Schmitz, Oliver J.
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Keywords Atmospheric pressure chemical ionization
Atmospheric pressure laser ionization
Atmospheric pressure ion sources
Atmospheric pressure photoionization
Gas chromatography – mass spectrometry
Language English
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Snippet Although the coupling of GC/MS with atmospheric pressure ionization (API) has been reported in 1970s, the interest in coupling GC with atmospheric pressure ion...
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SubjectTerms analytical chemistry
Animals
Atmospheric Pressure
Atmospheric pressure chemical ionization
Atmospheric pressure ion sources
Atmospheric pressure laser ionization
Atmospheric pressure photoionization
Equipment Design
Gas chromatography – mass spectrometry
Gas Chromatography-Mass Spectrometry - instrumentation
Gas Chromatography-Mass Spectrometry - methods
geometry
Humans
ionization
Metabolomics - instrumentation
Metabolomics - methods
Spectrometry, Mass, Electrospray Ionization - instrumentation
Spectrometry, Mass, Electrospray Ionization - methods
temperature
Title Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review
URI https://dx.doi.org/10.1016/j.aca.2015.08.002
https://www.ncbi.nlm.nih.gov/pubmed/26388363
https://www.proquest.com/docview/1715661053
https://www.proquest.com/docview/2000165450
Volume 891
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