Genome-wide pan-GPCR cell libraries accelerate drug discovery

• Published in: Acta pharmaceutica Sinica. B Vol. 14; no. 10; pp. 4296 - 4311
• Main Authors: Yang, Hanting, Wang, Yongfu, Liu, Wei, He, Taiping, Liao, Jiayu, Qian, Zhongzhi, Zhao, Jinghao, Cong, Zhaotong, Sun, Dan, Liu, Zhixiang, Wang, Can, Zhu, Lingping, Chen, Shilin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2024; Elsevier
• Subjects: Drug discovery; G-protein coupled receptors; Genome-wide pan-GPCR; High-throughput screening; Review; Transgenic cell library; High-throughput screening; Transgenic cell library; Genome-wide pan-GPCR; Drug discovery; G-protein coupled receptors

G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery. GPCRs account for about 40% of FDA-approved drugs, representing the most successful drug targets. However, only approximately 15% of the...