Identifying and removing haplotypic duplication in primary genome assemblies

• Published in: Bioinformatics Vol. 36; no. 9; pp. 2896 - 2898
• Main Authors: Guan, Dengfeng, McCarthy, Shane A, Wood, Jonathan, Howe, Kerstin, Wang, Yadong, Durbin, Richard
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2020
• Subjects: Applications Notes; Genome; Haplotypes; High-Throughput Nucleotide Sequencing; Sequence Analysis, DNA; Software

Abstract Motivation Rapid development in long-read sequencing and scaffolding technologies is accelerating the production of reference-quality assemblies for large eukaryotic genomes. However, haplotype divergence in regions of high heterozygosity often results in assemblers creating two copies rath...