Carbohydrate Response Element Binding Protein Gene Expression Is Positively Regulated by Thyroid Hormone

• Published in: Endocrinology (Philadelphia) Vol. 150; no. 7; pp. 3417 - 3424
• Main Authors: Hashimoto, Koshi, Ishida, Emi, Matsumoto, Shunichi, Okada, Shuichi, Yamada, Masanobu, Satoh, Teturou, Monden, Tsuyoshi, Mori, Masatomo
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Endocrine Society 01.07.2009; The Endocrine Society
• Subjects: Animals; Biological and medical sciences; Cell Line, Tumor; DNA-Binding Proteins - metabolism; Fundamental and applied biological sciences. Psychology; Humans; Liver - metabolism; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Nuclear Proteins - biosynthesis; Orphan Nuclear Receptors; Promoter Regions, Genetic - drug effects; Receptors, Cytoplasmic and Nuclear - metabolism; Thyroid Hormones - physiology; Transcription Factors - biosynthesis; Triiodothyronine - physiology; Up-Regulation; Vertebrates: endocrinology; Binding protein; Thyroid hormone; Carbohydrate; Gene expression; Response element

The molecular mechanism of thyroid hormone (TH) effects to fatty acid metabolism in liver is yet to be clear. The carbohydrate response element-binding protein (ChREBP) as well as sterol response element-binding protein (SREBP)-1c plays a pivotal role in hepatic lipogenesis. Both SREBP-1c and ChREBP...