Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 27; pp. 11205 - 11210
• Main Authors: Wykes, Michelle N, Kay, Jason G, Manderson, Anthony, Liu, Xue Q, Brown, Darren L, Richard, Derek J, Wipasa, Jiraprapa, Jiang, Suhua H, Jones, Malcolm K, Janse, Chris J, Waters, Andrew P, Pierce, Susan K, Miller, Louis H, Stow, Jennifer L, Good, Michael F
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 05.07.2011; National Acad Sciences
• Subjects: Animals; Animals, Genetically Modified; Antigens, CD - metabolism; Biological Sciences; Blood; Cell culture; confocal microscopy; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - parasitology; Dendritic Cells - ultrastructure; erythrocytes; Erythrocytes - parasitology; Female; Gene expression; genetically modified organisms; Green Fluorescent Proteins - genetics; hepatocytes; Humans; immunity; Infections; Malaria; Malaria - parasitology; Membrane Glycoproteins - metabolism; Merozoites; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Parasite hosts; Parasitemia; Parasites; Parasitic protozoa; Parasitism; Plasmodium - growth & development; Plasmodium - immunology; Plasmodium - pathogenicity; Plasmodium berghei - genetics; Plasmodium berghei - growth & development; Plasmodium berghei - pathogenicity; Plasmodium chabaudi - pathogenicity; Plasmodium falciparum; Plasmodium malariae; Plasmodium ovale; Plasmodium vivax; Plasmodium yoelii - pathogenicity; Recombinant Proteins - genetics; Rodents; Schizonts; Spleen; vaccine development; Virulence

Plasmodium spp. parasites cause malaria in 300 to 500 million individuals each year. Disease occurs during the blood-stage of the parasite's life cycle, where the parasite is thought to replicate exclusively within erythrocytes. Infected individuals can also suffer relapses after several years,...