Structure of hepatitis E viral particle

Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome. Recently, the three-dimensional structures of the HEV-like particles and spike domain protruded from th...

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Published in	Virus research Vol. 161; no. 1; pp. 59 - 64
Main Authors	Mori, Yoshio, Matsuura, Yoshiharu
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 01.10.2011
Subjects	Animals bacteria Baculoviridae Baculovirus capsid Capsid protein Capsid Proteins - chemistry Capsid Proteins - genetics Capsid Proteins - metabolism Crystal structure genome hepatitis E Hepatitis E - virology Hepatitis E virus Hepatitis E virus - chemistry Hepatitis E virus - genetics Hepatitis E virus - physiology Humans Orthohepevirus A Particle assembly RNA virion Virion - chemistry Virion - genetics Virion - physiology Virus Assembly viruses NOB Particle assembly ORF Capsid protein HEV HEV-LP HSPGs Hepatitis E virus Crystal structure
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Abstract	Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome. Recently, the three-dimensional structures of the HEV-like particles and spike domain protruded from the surface of the particle expressed by recombinant baculovirus or bacteria have been revealed. Based on these reports, the structural features of the HEV capsid subunit and viral particle are reviewed to give insights to the mechanisms underlying the particle assembly, antigenicity, host cell attachment and native virion packaging.
AbstractList	Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome. Recently, the three-dimensional structures of the HEV-like particles and spike domain protruded from the surface of the particle expressed by recombinant baculovirus or bacteria have been revealed. Based on these reports, the structural features of the HEV capsid subunit and viral particle are reviewed to give insights to the mechanisms underlying the particle assembly, antigenicity, host cell attachment and native virion packaging. Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome. Recently, the three-dimensional structures of the HEV-like particles and spike domain protruded from the surface of the particle expressed by recombinant baculovirus or bacteria have been revealed. Based on these reports, the structural features of the HEV capsid subunit and viral particle are reviewed to give insights to the mechanisms underlying the particle assembly, antigenicity, host cell attachment and native virion packaging.Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome. Recently, the three-dimensional structures of the HEV-like particles and spike domain protruded from the surface of the particle expressed by recombinant baculovirus or bacteria have been revealed. Based on these reports, the structural features of the HEV capsid subunit and viral particle are reviewed to give insights to the mechanisms underlying the particle assembly, antigenicity, host cell attachment and native virion packaging.
Author	Mori, Yoshio Matsuura, Yoshiharu
Author_xml	– sequence: 1 givenname: Yoshio surname: Mori fullname: Mori, Yoshio organization: Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan – sequence: 2 givenname: Yoshiharu surname: Matsuura fullname: Matsuura, Yoshiharu email: matsuura@biken.osaka-u.ac.jp organization: Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/21440590$$D View this record in MEDLINE/PubMed
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Keywords	NOB Particle assembly ORF Capsid protein HEV HEV-LP HSPGs Hepatitis E virus Crystal structure
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Snippet	Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus...
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SubjectTerms	Animals bacteria Baculoviridae Baculovirus capsid Capsid protein Capsid Proteins - chemistry Capsid Proteins - genetics Capsid Proteins - metabolism Crystal structure genome hepatitis E Hepatitis E - virology Hepatitis E virus Hepatitis E virus - chemistry Hepatitis E virus - genetics Hepatitis E virus - physiology Humans Orthohepevirus A Particle assembly RNA virion Virion - chemistry Virion - genetics Virion - physiology Virus Assembly viruses
Title	Structure of hepatitis E viral particle
URI	https://dx.doi.org/10.1016/j.virusres.2011.03.015 https://www.ncbi.nlm.nih.gov/pubmed/21440590 https://www.proquest.com/docview/2000007099 https://www.proquest.com/docview/893989497 https://www.proquest.com/docview/902376425
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