Exercise intervention lowers aberrant serum WISP-1 levels with insulin resistance in breast cancer survivors: a randomized controlled trial

• Published in: Scientific reports Vol. 10; no. 1; p. 10898
• Main Authors: Chang, Jae Seung, Kim, Tae Ho, Kong, In Deok
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.07.2020; Nature Publishing Group
• Subjects: 692/308/2779/777; 692/699/67/1347; 692/700/459/284; beta Catenin - blood; Biomarkers; Blood Glucose - analysis; Body Composition; Body fat; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - rehabilitation; Cancer Survivors; CCN Intercellular Signaling Proteins - blood; Exercise; Exercise Therapy; Fitness training programs; Glucose metabolism; Humanities and Social Sciences; Humans; Insulin; Insulin Resistance; Lipids - blood; Metastases; Middle Aged; multidisciplinary; Physical Fitness; Physical training; Prognosis; Proto-Oncogene Proteins - blood; Resistance Training; Science; Science (multidisciplinary); Serum levels; Signal transduction; Wnt protein; Wnt Signaling Pathway; β-Catenin

Insulin resistance is associated with increased risk for and recurrence of breast cancer. Recently, Wnt1-inducible signaling pathway protein-1 (WISP-1) was reported to impair glucose metabolism and insulin sensitivity. In various cancer tissues, Wnt signaling is upregulated and induces further oncog...