Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 36; pp. 14944 - 14949
• Main Authors: Toller, Isabella M, Neelsen, Kai J, Steger, Martin, Hartung, Mara L, Hottiger, Michael O, Stucki, Manuel, Kalali, Behnam, Gerhard, Markus, Sartori, Alessandro A, Lopes, Massimo, Müller, Anne
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 06.09.2011; National Acad Sciences
• Series: From the Cover
• Subjects: Adhesins; Animals; Antigens, Bacterial - genetics; Antigens, Bacterial - metabolism; Ataxia telangiectasia mutated protein; Ataxia Telangiectasia Mutated Proteins; Bacteria; Bacterial Adhesion; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biological Sciences; blood; Blood groups; Carcinogenesis; carcinogenicity; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cell lines; Cell nucleus; Cells; Chromosomal Proteins, Non-Histone - genetics; Chromosomal Proteins, Non-Histone - metabolism; Chromosome Aberrations; Chromosomes; Cultured cells; Cytotoxins; direct contact; DNA; DNA Breaks, Double-Stranded; DNA damage; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - microbiology; Epithelial Cells - pathology; gamma -Glutamyltransferase; Gastric cancer; Gastric mucosa; Gel electrophoresis; genes; Genomic Islands; genomics; Gram-negative bacteria; Helicobacter Infections - complications; Helicobacter Infections - metabolism; Helicobacter Infections - pathology; Helicobacter pylori; Helicobacter pylori - metabolism; Histone H2A; histones; Histones - genetics; Histones - metabolism; Humans; Infection; Infections; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Mammalian cells; Mesenchyme; Metaphase; Mice; Microscopy; Molecular modelling; mutagenicity; nuclear genome; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; pathogenicity islands; Pathogens; Phosphorylation; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; pulsed-field gel electrophoresis; recruitment; Risk factors; Rodents; stomach neoplasms; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Trans-Activators - genetics; Trans-Activators - metabolism; Tumor Suppressor p53-Binding Protein 1; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; virulence; virulence factors

The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric carcinogenesis remain ill defined. In this study, we examined the possibility that H....