ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity

• Published in: Neoplasia (New York, N.Y.) Vol. 67; p. 101194
• Main Authors: Liu, Yiming, Jiang, Xingyu, Jing, Dongquan, Lin, Yanting, Gao, Rui, Zhao, Qixiang, Da, Huijuan, Ren, Yiming, Cao, Qiuhua, Liu, Ning, Han, Xiaoyun, Du, Juan, Gao, Xinghua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2025; Neoplasia Press; Elsevier
• Subjects: ACSL4; Animals; B7-H1 Antigen - antagonists & inhibitors; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Line, Tumor; Cell Proliferation; Coenzyme A Ligases - genetics; Coenzyme A Ligases - metabolism; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - immunology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Long-Chain-Fatty-Acid-CoA Ligase; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Mice; Original Research; Prognosis; RIG-I-MAVS; Signal Transduction; Tumor immunity; Type I Interferon; Xenograft Model Antitumor Assays; ACSL4; Type I Interferon; Tumor immunity; Colorectal cancer; RIG-I-MAVS

Background: Long-chain acyl-CoA synthetase 4 (ACSL4), a crucial modulator of ferroptosis, is associated with tumor progression, though its impact on colorectal cancer (CRC) immune dynamics is not fully understood. Methods: ACSL4 expression was analyzed in CRC tissues and correlated with patient prog...