Non-invasive MRI measurements of age-dependent in vivo human glymphatic exchange using magnetization transfer spin labeling

• Published in: NeuroImage (Orlando, Fla.) Vol. 310; p. 121142
• Main Authors: Kim, Dahan, Huang, Yujia, Liu, Jiaen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2025; Elsevier Limited; Elsevier
• Subjects: Adult; Age; Aged; Aging - metabolism; Atrophy; Brain; Brain - diagnostic imaging; Brain - metabolism; Cerebrospinal fluid; Cerebrospinal Fluid - diagnostic imaging; Cerebrospinal Fluid - metabolism; Experiments; Female; Glucose; Glymphatic System - diagnostic imaging; Glymphatic System - metabolism; Glymphatic system, cerebrospinal fluid, magnetization transfer, Alzheimer's disease; Human subjects; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Measurement techniques; Metabolism; Middle Aged; Neurodegeneration; Optimization; Parenchyma; Simulation; Solutes; Spin labeling; Spin Labels; Statistical analysis; Subarachnoid space; Water; Water exchange; Young Adult; Glymphatic system, cerebrospinal fluid, magnetization transfer, Alzheimer's disease

•A non-invasive MRI technique was developed and optimized to yield in vivo water exchange measurements between human brain parenchyma and CSF, using repeating magnetization transfer saturation labeling of interstitial spins, followed by partial CSF saturation measurement.•Bloch simulations and phant...