Dissipative particle dynamics simulation of multicompartment micelle nanoreactor with channel for reactants
The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application. It turns out that well-defined multicompartment micelles with channel structures can be generated through the self-assembly of triblock copolyme...
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Published in | RSC advances Vol. 8; no. 66; pp. 37866 - 37871 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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England
Royal Society of Chemistry
12.11.2018
The Royal Society of Chemistry |
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Abstract | The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application. It turns out that well-defined multicompartment micelles with channel structures can be generated through the self-assembly of triblock copolymers consisting of a hydrophilic (A), a lipophilic (B), and a fluorophobic (C) block arranged in a B-A-C sequence: The corona and core are formed by the hydrophilic A block and the fluorophilic C block, respectively while the channel between the aqueous phase and core is formed by the lipophilic B block and the core. By performing a set of simulations, it is confirmed that channel size can be controlled as a function of the block length ratios between blocks A and B. Furthermore, it is also confirmed that the reactants pass through such channels to reach the micelle core by analyzing the pair correlation functions. By monitoring the change of the number of reactants in the multicompartment micelle, it is revealed that the diffusion of reactants into the core is slowed down as the concentration gradient is decreased. This work provides mesoscopic insight for the formation of multicompartment micelles and transport of reactants for use in the design of micelles as nanoreactors.
The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application. |
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AbstractList | The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application. It turns out that well-defined multicompartment micelles with channel structures can be generated through the self-assembly of triblock copolymers consisting of a hydrophilic (A), a lipophilic (B), and a fluorophobic (C) block arranged in a B–A–C sequence: The corona and core are formed by the hydrophilic A block and the fluorophilic C block, respectively while the channel between the aqueous phase and core is formed by the lipophilic B block and the core. By performing a set of simulations, it is confirmed that channel size can be controlled as a function of the block length ratios between blocks A and B. Furthermore, it is also confirmed that the reactants pass through such channels to reach the micelle core by analyzing the pair correlation functions. By monitoring the change of the number of reactants in the multicompartment micelle, it is revealed that the diffusion of reactants into the core is slowed down as the concentration gradient is decreased. This work provides mesoscopic insight for the formation of multicompartment micelles and transport of reactants for use in the design of micelles as nanoreactors.
The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application. The structural variation of multicompartment micelles is investigated using a dissipative particle dynamics simulation method for nano-reactor application. It turns out that well-defined multicompartment micelles with channel structures can be generated through the self-assembly of triblock copolymers consisting of a hydrophilic (A), a lipophilic (B), and a fluorophobic (C) block arranged in a B–A–C sequence: The corona and core are formed by the hydrophilic A block and the fluorophilic C block, respectively while the channel between the aqueous phase and core is formed by the lipophilic B block and the core. By performing a set of simulations, it is confirmed that channel size can be controlled as a function of the block length ratios between blocks A and B. Furthermore, it is also confirmed that the reactants pass through such channels to reach the micelle core by analyzing the pair correlation functions. By monitoring the change of the number of reactants in the multicompartment micelle, it is revealed that the diffusion of reactants into the core is slowed down as the concentration gradient is decreased. This work provides mesoscopic insight for the formation of multicompartment micelles and transport of reactants for use in the design of micelles as nanoreactors. |
Author | Lee, Seung Min Farmer, Emily Jang, Seung Soon Bond, Nicholas Clark, Benjamin Mallard, MacKensie Callaway, Connor |
AuthorAffiliation | Institute for Electronics and Nanotechnology Computational NanoBio Technology Laboratory School of Materials Science and Engineering Strategic Energy Institute Parker H. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology |
AuthorAffiliation_xml | – name: Computational NanoBio Technology Laboratory – name: School of Materials Science and Engineering – name: Institute for Electronics and Nanotechnology – name: Georgia Institute of Technology – name: Parker H. Petit Institute for Bioengineering and Bioscience – name: Strategic Energy Institute |
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SubjectTerms | Block copolymers Chemistry Concentration gradient Correlation analysis Diffusion rate Dynamic structural analysis Micelles NANOSCIENCE AND NANOTECHNOLOGY Self-assembly Simulation |
Title | Dissipative particle dynamics simulation of multicompartment micelle nanoreactor with channel for reactants |
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