Pharmacokinetic Properties of the Nephrotoxin Orellanine in Rats

• Published in: Toxins Vol. 10; no. 8; p. 333
• Main Authors: Najar, Deman, Haraldsson, Börje, Thorsell, Annika, Sihlbom, Carina, Nyström, Jenny, Ebefors, Kerstin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.08.2018; MDPI
• Subjects: 1983; 1985; 1988; 1990; anesthesia; archives of toxicology; Arteries; ast h; Bladder; Cancer; clearance; cortinarius-orellanus; Dialysis; Food Science & Technology; fries; fungal toxin; Half-life; hmlow ev; humacher t; ingestion; kidney; Kidney cancer; Kidneys; Laboratory animals; lpech n; Metabolites; Metastases; Metastasis; Molecular weight; mushroom nephrotoxin; Mushrooms; Nephrology; Neurosciences; Neurovetenskaper; orellanine; p122; p4903; p87; p89; Peritoneal dialysis; Peritoneum; Pharmacokinetics; Pharmacology; Physiology; Poisoning; presse medicale; radicals; Rats; Renal artery; Renal cortex; Renal failure; renal-cell carcinoma; Studies; tetrahedron letters; Toxicology; v19; v26; v53; v62; Sweden; clearance; fungal toxin; half-life; orellanine

Orellanine is a nephrotoxin found in mushrooms of the Cortinarius family. Accidental intake of this substance may cause renal failure. Orellanine is specific for proximal tubular cells and could, therefore, potentially be used as treatment for metastatic renal cancer, which originates from these cel...