Human umbilical cord mesenchymal stem cell-derived exosomes promote neurological function recovery in rat after traumatic brain injury by inhibiting the activation of microglia and astrocyte
Traumatic brain injury (TBI) is a serious neurological disorder with increasing worldwide incidence. Emerging evidence has shown a significant therapeutic role of mesenchymal stem cells (MSCs) derived exosomes on traumatic brain injury with broad application prospects as a cell-free therapy. However...
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| Published in | Regenerative therapy Vol. 21; pp. 282 - 287 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.12.2022
Japanese Society for Regenerative Medicine Elsevier |
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| Abstract | Traumatic brain injury (TBI) is a serious neurological disorder with increasing worldwide incidence. Emerging evidence has shown a significant therapeutic role of mesenchymal stem cells (MSCs) derived exosomes on traumatic brain injury with broad application prospects as a cell-free therapy. However, a comprehensive understanding of its underlying mechanism remained elusive. In this study, umbilical cord mesenchymal stem cells (UCMSCs)-derived exosomes (UC-MSCs-Exo) were isolated by ultracentrifugation and injected intraventricularly in a rat model of TBI. Our results showed that UC-MSCs-Exo promoted functional recovery and reduced neuronal apoptosis in TBI rats. Moreover, UC-MSCs-Exo inhibited the activation of microglia and astrocytes during brain injury, thereby promoting functional recovery. However, the effect of UC-MSCs-Exo on the content of plasma inflammatory factors in rats was not significant. Collectively our study suggested that UC-MSCs-Exo promotes the recovery of neurological function in TBI rats by inhibiting the activation of microglia and astrocytes, providing a theoretical basis for new therapeutic strategies for central nervous system diseases. |
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| AbstractList | Traumatic brain injury (TBI) is a serious neurological disorder with increasing worldwide incidence. Emerging evidence has shown a significant therapeutic role of mesenchymal stem cells (MSCs) derived exosomes on traumatic brain injury with broad application prospects as a cell-free therapy. However, a comprehensive understanding of its underlying mechanism remained elusive. In this study, umbilical cord mesenchymal stem cells (UCMSCs)-derived exosomes (UC-MSCs-Exo) were isolated by ultracentrifugation and injected intraventricularly in a rat model of TBI. Our results showed that UC-MSCs-Exo promoted functional recovery and reduced neuronal apoptosis in TBI rats. Moreover, UC-MSCs-Exo inhibited the activation of microglia and astrocytes during brain injury, thereby promoting functional recovery. However, the effect of UC-MSCs-Exo on the content of plasma inflammatory factors in rats was not significant. Collectively our study suggested that UC-MSCs-Exo promotes the recovery of neurological function in TBI rats by inhibiting the activation of microglia and astrocytes, providing a theoretical basis for new therapeutic strategies for central nervous system diseases. Traumatic brain injury (TBI) is a serious neurological disorder with increasing worldwide incidence. Emerging evidence has shown a significant therapeutic role of mesenchymal stem cells (MSCs) derived exosomes on traumatic brain injury with broad application prospects as a cell-free therapy. However, a comprehensive understanding of its underlying mechanism remained elusive. In this study, umbilical cord mesenchymal stem cells (UCMSCs)-derived exosomes (UC-MSCs-Exo) were isolated by ultracentrifugation and injected intraventricularly in a rat model of TBI. Our results showed that UC-MSCs-Exo promoted functional recovery and reduced neuronal apoptosis in TBI rats. Moreover, UC-MSCs-Exo inhibited the activation of microglia and astrocytes during brain injury, thereby promoting functional recovery. However, the effect of UC-MSCs-Exo on the content of plasma inflammatory factors in rats was not significant. Collectively our study suggested that UC-MSCs-Exo promotes the recovery of neurological function in TBI rats by inhibiting the activation of microglia and astrocytes, providing a theoretical basis for new therapeutic strategies for central nervous system diseases.Traumatic brain injury (TBI) is a serious neurological disorder with increasing worldwide incidence. Emerging evidence has shown a significant therapeutic role of mesenchymal stem cells (MSCs) derived exosomes on traumatic brain injury with broad application prospects as a cell-free therapy. However, a comprehensive understanding of its underlying mechanism remained elusive. In this study, umbilical cord mesenchymal stem cells (UCMSCs)-derived exosomes (UC-MSCs-Exo) were isolated by ultracentrifugation and injected intraventricularly in a rat model of TBI. Our results showed that UC-MSCs-Exo promoted functional recovery and reduced neuronal apoptosis in TBI rats. Moreover, UC-MSCs-Exo inhibited the activation of microglia and astrocytes during brain injury, thereby promoting functional recovery. However, the effect of UC-MSCs-Exo on the content of plasma inflammatory factors in rats was not significant. Collectively our study suggested that UC-MSCs-Exo promotes the recovery of neurological function in TBI rats by inhibiting the activation of microglia and astrocytes, providing a theoretical basis for new therapeutic strategies for central nervous system diseases. |
| Author | Liu, Xiaocui Xu, Junrong Luo, Wei Jiang, Wenkang Wang, Bingyun Chen, Guoqiang Cui, Lianxu Li, Haomin Wang, Jinhui |
| Author_xml | – sequence: 1 givenname: Lianxu surname: Cui fullname: Cui, Lianxu organization: The First People’s Hospital of Foshan, Foshan, Guangdong Province, 528000, China – sequence: 2 givenname: Wei surname: Luo fullname: Luo, Wei organization: The First People’s Hospital of Foshan, Foshan, Guangdong Province, 528000, China – sequence: 3 givenname: Wenkang surname: Jiang fullname: Jiang, Wenkang organization: School of Life Science and Engineering, Foshan University, Foshan, Guangdong Province, 528225, China – sequence: 4 givenname: Haomin surname: Li fullname: Li, Haomin organization: The First People’s Hospital of Foshan, Foshan, Guangdong Province, 528000, China – sequence: 5 givenname: Junrong surname: Xu fullname: Xu, Junrong organization: Guangdong VitaLife Biotech Co., Foshan, Guangdong Province, 528251, China – sequence: 6 givenname: Xiaocui surname: Liu fullname: Liu, Xiaocui organization: Guangdong VitaLife Biotech Co., Foshan, Guangdong Province, 528251, China – sequence: 7 givenname: Bingyun surname: Wang fullname: Wang, Bingyun organization: School of Life Science and Engineering, Foshan University, Foshan, Guangdong Province, 528225, China – sequence: 8 givenname: Jinhui surname: Wang fullname: Wang, Jinhui email: wangjinhui@vtlife.cn organization: Guangdong VitaLife Biotech Co., Foshan, Guangdong Province, 528251, China – sequence: 9 givenname: Guoqiang surname: Chen fullname: Chen, Guoqiang email: 13929981788@139.com organization: The First People’s Hospital of Foshan, Foshan, Guangdong Province, 528000, China |
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| Keywords | Umbilical cord mesenchymal stem cells Traumatic brain injury Exosomes Astrocytes Microglia |
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| Title | Human umbilical cord mesenchymal stem cell-derived exosomes promote neurological function recovery in rat after traumatic brain injury by inhibiting the activation of microglia and astrocyte |
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