Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery

• Published in: Molecular therapy. Nucleic acids Vol. 32; pp. 568 - 581
• Main Authors: Zhang, Jiayu, Cai, Xiaomeng, Dou, Rui, Guo, Chen, Tang, Jiaruo, Hu, Yi, Chen, Hanqing, Chen, Jun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.06.2023; American Society of Gene & Cell Therapy; Elsevier
• Subjects: gene delivery; MT: Delivery Strategies; Poly(β-amino) esters (PβAEs); polymer; Review; vaccines; polymer; gene delivery; Poly(β-amino) esters (PβAEs); MT: Delivery Strategies; vaccines

The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer...