Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery

The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer...

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Published inMolecular therapy. Nucleic acids Vol. 32; pp. 568 - 581
Main Authors Zhang, Jiayu, Cai, Xiaomeng, Dou, Rui, Guo, Chen, Tang, Jiaruo, Hu, Yi, Chen, Hanqing, Chen, Jun
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.06.2023
American Society of Gene & Cell Therapy
Elsevier
Subjects
gene delivery
MT: Delivery Strategies
Poly(β-amino) esters (PβAEs)
polymer
Review
vaccines
polymer
gene delivery
Poly(β-amino) esters (PβAEs)
MT: Delivery Strategies
vaccines
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Abstract The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs. [Display omitted] Chen and colleagues evaluate poly(β-amino) esters (PβAEs) as a promising non-viral gene vector material, discussing their simple synthesis, diverse monomers, and customizable structure for various gene delivery needs. Additionally, the review explores intrinsic structure-effect correlations through rational design and concludes by discussing PβAEs' applications and future prospects.
AbstractList The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs.The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs.
The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs.
The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs. Chen and colleagues evaluate poly(β-amino) esters (PβAEs) as a promising non-viral gene vector material, discussing their simple synthesis, diverse monomers, and customizable structure for various gene delivery needs. Additionally, the review explores intrinsic structure-effect correlations through rational design and concludes by discussing PβAEs' applications and future prospects.
The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the capability of ferrying gene molecules. Moreover, the synthesis process of PβAEs is simple, the monomers are readily available, and the polymer structure can be tailored to meet different gene delivery needs by adjusting the monomer type, monomer ratio, reaction time, etc. Therefore, PβAEs are a promising class of non-viral gene vector materials. This review paper presents a comprehensive overview of the synthesis and correlated properties of PβAEs and summarizes the progress of each type of PβAE for gene delivery. The review focuses in particular on the rational design of PβAE structures, thoroughly discusses the correlations between intrinsic structure and effect, and then finishes with the applications and perspectives of PβAEs. [Display omitted] Chen and colleagues evaluate poly(β-amino) esters (PβAEs) as a promising non-viral gene vector material, discussing their simple synthesis, diverse monomers, and customizable structure for various gene delivery needs. Additionally, the review explores intrinsic structure-effect correlations through rational design and concludes by discussing PβAEs' applications and future prospects.
Author Guo, Chen
Hu, Yi
Tang, Jiaruo
Chen, Hanqing
Chen, Jun
Zhang, Jiayu
Dou, Rui
Cai, Xiaomeng
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37200860$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/s41467-019-11190-0
10.1038/ncomms9385
10.3390/ijms20215491
10.1021/bc034067y
10.1002/adfm.201601703
10.1016/j.biomaterials.2014.10.037
10.1038/s41598-021-86773-3
10.1021/acs.biomac.5b00062
10.1021/bm0504983
10.1021/ja026405w
10.1021/bc7002082
10.1021/la048888i
10.1021/bc0600968
10.1039/C7SC03913A
10.1557/s43579-022-00257-7
10.1002/adfm.202204462
10.1016/j.jconrel.2005.04.014
10.1007/s11095-005-8343-0
10.1016/S0168-3659(00)00368-0
10.1002/jbm.a.32983
10.1016/j.jconrel.2019.08.024
10.1021/acs.nanolett.9b00737
10.1021/acs.biomac.6b01120
10.3390/polym9050161
10.1016/j.jconrel.2005.06.022
10.1039/c2jm15277k
10.1016/j.jconrel.2020.06.038
10.1126/sciadv.1600102
10.1021/ja016288p
10.1007/s10118-020-2393-y
10.1039/C9BM01452G
10.1016/j.actbio.2020.06.042
10.1016/j.matt.2021.12.022
10.1021/ja001033h
10.1023/A:1016054623543
10.1016/j.ymthe.2004.11.015
10.1021/ja403167p
10.1021/acs.biomac.5b00966
10.1002/jbm.a.31494
10.1016/j.biomaterials.2012.01.046
10.1016/j.eurpolymj.2020.110097
10.1073/pnas.0403549101
10.1016/j.biomaterials.2017.02.019
10.1002/adma.200901718
10.1038/s41392-022-00950-y
10.1016/j.actbio.2021.06.023
10.1016/j.biomaterials.2013.10.017
10.1021/nn300960m
10.1016/j.actbio.2015.03.029
10.1016/j.biomaterials.2015.01.049
10.1016/j.actbio.2016.10.015
10.1073/pnas.0407218101
10.1016/j.biomaterials.2013.05.081
10.1021/bm0601878
10.1007/s11095-007-9448-4
10.1002/mabi.201400424
10.1039/c0py00074d
10.1016/j.actbio.2021.08.042
10.1021/ja0015388
10.1021/bm900724c
10.1021/mp100390w
10.1021/ja061570n
10.1016/j.actbio.2014.09.020
10.1021/acsbiomaterials.6b00503
10.1016/j.jconrel.2016.06.014
10.1021/ja984012k
10.1002/marc.1983.030041009
10.1088/1361-6528/aac4b5
10.1021/bm0604808
10.1002/adhm.201200257
10.1021/am400017q
10.1021/mz500277j
10.1039/C6PY01664B
10.1021/nn500704t
10.1016/S0041-0101(01)00165-9
10.1002/adma.200700371
10.1016/j.nano.2016.10.001
10.1016/j.ebiom.2020.102897
10.1002/jgm.1252
10.1002/pola.10322
10.1002/adhm.201601041
10.3390/nano8110952
10.1016/j.biomaterials.2013.06.044
10.1021/acsbiomaterials.8b01051
10.1021/ja4002376
10.1002/smll.201502554
10.3389/fphar.2022.854859
10.1016/j.gene.2013.03.137
10.1016/j.eurpolymj.2018.08.029
10.1002/anie.200351244
10.1016/j.addr.2015.09.012
10.1021/bc900317m
10.1021/acs.molpharmaceut.8b00549
10.1002/anie.201608450
10.1080/21691401.2017.1307215
10.1016/j.polymer.2006.12.008
10.1038/mt.2012.79
10.1002/adhm.201400235
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Keywords polymer
gene delivery
Poly(β-amino) esters (PβAEs)
MT: Delivery Strategies
vaccines
Language English
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References Wang, Burdick (bib76) 2017; 6
Rodriguez-Garcia, Surman, Cooper, Suárez-Marina, Hosni, Lee, Cronin (bib45) 2015; 6
Liu, Chen, Xue, Liu, Zhuo, Huang (bib18) 2009; 20
Gao, Tang, Yan (bib66) 2002; 40
Liu, Gao, Zhou, Zeng, Alshehri, Newland, Lyu, O'Keeffe-Ahern, Greiser, Guo (bib49) 2019; 10
Bardhan (bib6) 2022; 12
Galli, Laus, Angeloni, Ferruti, Chiellini (bib7) 1983; 4
Wang, Chen, Liu, Wu, Zhou, Wang, Li, Yang, Zhang (bib56) 2013; 34
Wu, Liu, Jiang, Chen, He, Goh, Leong (bib67) 2005; 6
Lynn, Anderson, Putnam, Langer (bib35) 2001; 123
Jewell, Zhang, Fredin, Lynn (bib86) 2005; 106
Lynn, Langer (bib8) 2000; 122
Cordeiro, Serra, Coelho, Faneca (bib16) 2019; 310
Iqbal, Martins, Sohail, Zhao, Deng, Li, Zhao (bib17) 2022; 13
Niu, Jin, Zhang, He, Gao, Zou, Zhang, Ding, Das, Severinov (bib94) 2020; 58
Perni, Preedy, Prokopovich (bib30) 2021; 11
Iqbal, Qu, Dong, Zhao, Rauf Khan, Rehman, Zhao (bib15) 2020; 141
Duan, Cao, Li, Zhu, Lan, Tan, Song, Zhu, Yin, Chen (bib40) 2020; 8
Wu, Liu, Jiang, He, Goh, Leong (bib70) 2006; 7
Tzeng, Green (bib58) 2013; 2
Lim, Choi, Park (bib96) 1999; 121
Liu, Chen, Tang, Li, Dou, Zheng (bib51) 2018; 15
Yu, Han, Kou, Dai, Liu, Wei, Li, Jiang, Sun (bib75) 2018; 46
Shenoy, Little, Langer, Amiji (bib10) 2005; 22
Li, Zhang, Ho, Bai, Jaijyan, Li, Kumar, Kolloli, Subbian, Zhu (bib92) 2022; 32
Tang, Yin, Su, Sun, Meng, Chen, Chen, Huang, Gu, Xu (bib62) 2015; 48
Liu, Gao, Sigen, Zhou, Greiser, Guo, Guo, Wang (bib53) 2017; 3
Gao, Huang, O'Keeffe Ahern, Cutlar, Zhou, Lin, Wang (bib72) 2016; 17
Chen, Zehtabi, Ouyang, Kong, Zhong, Xing (bib34) 2012; 22
Zugates, Tedford, Zumbuehl, Jhunjhunwala, Kang, Griffith, Lauffenburger, Langer, Anderson (bib44) 2007; 18
Little, Lynn, Ge, Anderson, Puram, Chen, Eisen, Langer (bib89) 2004; 101
Kaneo, Tanaka, Nakano, Yamaguchi (bib57) 2001; 70
Anderson, Lynn, Langer (bib22) 2003; 42
Sunshine, Green, Mahon, Yang, Eltoukhy, Nguyen, Langer, Anderson (bib42) 2009; 21
Zhang, Satterlee, Huang (bib9) 2012; 20
Viger, Sankaranarayanan, de Gracia Lux, Chan, Almutairi (bib13) 2013; 135
Lim, Kim, Kim, Kim, Park (bib97) 2000; 122
Zugates, Anderson, Little, Lawhorn, Langer (bib27) 2006; 128
Segovia, Pont, Oliva, Ramos, Borrós, Artzi (bib80) 2015; 4
Arote, Hwang, Yoo, Jere, Jiang, Kim, Choi, Nah, Cho, Cho (bib26) 2008; 10
Anderson, Akinc, Hossain, Langer (bib23) 2005; 11
Tang, Meng, Sun, Su, Yin, Zhang, Yu, Chen, Chen, Gu (bib63) 2016; 26
Green, Zugates, Tedford, Huang, Griffith, Lauffenburger, Sawicki, Langer, Anderson (bib43) 2007; 19
Safranski, Weiss, Clark, Caspersen, Taylor, Gall (bib14) 2011; 96
Persano, Guevara, Li, Mai, Ferrari, Pompa, Shen (bib91) 2017; 125
Eltoukhy, Siegwart, Alabi, Rajan, Langer, Anderson (bib28) 2012; 33
Fang, Liu, Li, Zhang, Song, Zhu, Wu, Liu, Zhao, Li (bib4) 2022; 7
Bishop, Tzeng, Green (bib88) 2015; 11
Patil, Gao, Lin, Li, Dang, Tian, Zhang, Jiang, Qadir, Qian (bib3) 2019; 20
Perni, Prokopovich (bib31) 2017; 13
Xu, Guo, Sigen, Gao, Zhou, Greiser, Creagh-Flynn, Zhang, Dong, Cutlar (bib95) 2018; 9
Shmueli, Ohnaka, Miki, Pandey, Lima e Silva, Koskimaki, Kim, Popel, Campochiaro, Green (bib29) 2013; 34
Cordeiro, Farinha, Rocha, Serra, Faneca, Coelho (bib64) 2015; 15
Wirth, Parker, Ylä-Herttuala (bib1) 2013; 525
Zhong, Song, Engbersen, Lok, Hennink, Feijen (bib69) 2005; 109
McBath, Shipp (bib79) 2010; 1
Mastorakos, Song, Zhang, Berry, Park, Kim, Park, Lee, Suk, Hanes (bib60) 2016; 12
Pilkington, Suys, Trevaskis, Wheatley, Zukancic, Algarni, Al-Wassiti, Davis, Pouton, Kent (bib5) 2021; 131
Zhang, Wang, Li, Li, Chen, Xiong, Liu, Wang (bib55) 2018; 29
Wen, Zhou, Lu, Bi, Ruan, Chen, Hu (bib83) 2018; 4
Zeng, Zhou, Ng, Ahern, Alshehri, Gao, Pierucci, Greiser, Wang (bib73) 2017; 9
Suk, Xu, Kim, Hanes, Ensign (bib59) 2016; 99
Chen, Ouyang, Kong, Zhong, Xing (bib11) 2013; 5
Jones, Chen, Ravikrishnan, Reddinger, Zhang, Hakansson, Pfeifer (bib47) 2015; 37
Zhou, Zhang, Xie, Qi, Lu, Leporatti, Chen, Hu (bib82) 2018; 8
Chen, Wu, Oupický (bib21) 2009; 10
Su, Fricke, Kavanagh, Irvine (bib90) 2011; 8
Wang, Wang, Lie, Zhou, Huang, Wang (bib74) 2020; 38
Zhang, Bré, Zhao, Zheng, Newland, Wang (bib68) 2014; 35
Zhou, Gao, Aied, Cutlar, Igoucheva, Newland, Alexeeve, Greiser, Uitto, Wang (bib71) 2016; 244
Zhou, Huang, Wang, Lu, Chen, Chai, Yao, Hu (bib81) 2019; 19
Green, Shi, Chiu, Leshchiner, Langer, Anderson (bib38) 2006; 17
Vázquez, Dewitt, Hammond, Lynn (bib84) 2002; 124
Bishop, Ketola, Tzeng, Sunshine, Urtti, Lemmetyinen, Vuorimaa-Laukkanen, Yliperttula, Green (bib37) 2013; 135
Chou, Berger, Jalili-Firoozinezhad, Hammond (bib77) 2021; 135
Chen, Huang, Liu, Zhuo (bib19) 2007; 48
Abramson, Kirtane, Shi, Zhong, Collins, Tamang, Ishida, Hayward, Wainer, Rajesh (bib98) 2022; 5
Cherng, van de Wetering, Talsma, Crommelin, Hennink (bib36) 1996; 13
Zhang, Chua, Lynn (bib85) 2004; 20
Wang, Wan, Liu, Chen, Chen, Zhang, Wang, Xiong, Zhang, Wang (bib54) 2016; 7
Est-Witte, Farris, Tzeng, Hutton, Gong, Calabresi, Grayson, Green (bib93) 2020; 113
Dosta, Segovia, Cascante, Ramos, Borrós (bib46) 2015; 20
Anderson, Peng, Akinc, Hossain, Kohn, Padera, Langer, Sawicki (bib25) 2004; 101
Jewell, Zhang, Fredin, Wolff, Hacker, Lynn (bib87) 2006; 7
Jere, Yoo, Arote, Kim, Cho, Nah, Choi, Cho (bib61) 2008; 25
Cordeiro, Santo, Farinha, Serra, Faneca, Coelho (bib65) 2017; 47
Cutlar, Zhou, Gao, Zhao, Greiser, Wang, Wang (bib20) 2015; 16
Bingol, Demir Duman, Yagci Acar, Yagci, Avci (bib50) 2018; 108
Brey, Erickson, Burdick (bib24) 2008; 85
Kozielski, Tzeng, De Mendoza, Green (bib39) 2014; 8
Jones, Chen, Gollakota, Ravikrishnan, Zhang, Lin, Tan, Cheng, Lin, Pfeifer (bib48) 2015; 16
Dohmen, Edinger, Fröhlich, Schreiner, Lächelt, Troiber, Rädler, Hadwiger, Vornlocher, Wagner (bib52) 2012; 6
Zhou, Cutlar, Gao, Wang, O'Keeffe-Ahern, McMahon, Duarte, Larcher, Rodriguez, Greiser (bib32) 2016; 2
Kaczmarek, Patel, Kauffman, Fenton, Webber, Heartlein, DeRosa, Anderson (bib78) 2016; 55
Akinc, Anderson, Lynn, Langer (bib33) 2003; 14
Mohammadinejad, Dehshahri, Sagar Madamsetty, Zahmatkeshan, Tavakol, Makvandi, Khorsandi, Pardakhty, Ashrafizadeh, Ghasemipour Afshar (bib2) 2020; 325
Collier (bib41) 2001; 39
Zhang, Wang, Hua, Baumgartner, Cheng (bib12) 2014; 3
Anderson (10.1016/j.omtn.2023.04.019_bib23) 2005; 11
Abramson (10.1016/j.omtn.2023.04.019_bib98) 2022; 5
Viger (10.1016/j.omtn.2023.04.019_bib13) 2013; 135
Jones (10.1016/j.omtn.2023.04.019_bib47) 2015; 37
Wu (10.1016/j.omtn.2023.04.019_bib67) 2005; 6
Cherng (10.1016/j.omtn.2023.04.019_bib36) 1996; 13
Duan (10.1016/j.omtn.2023.04.019_bib40) 2020; 8
Collier (10.1016/j.omtn.2023.04.019_bib41) 2001; 39
Chen (10.1016/j.omtn.2023.04.019_bib21) 2009; 10
Zhang (10.1016/j.omtn.2023.04.019_bib9) 2012; 20
Persano (10.1016/j.omtn.2023.04.019_bib91) 2017; 125
Zhou (10.1016/j.omtn.2023.04.019_bib32) 2016; 2
Zugates (10.1016/j.omtn.2023.04.019_bib27) 2006; 128
Zhou (10.1016/j.omtn.2023.04.019_bib71) 2016; 244
Zhou (10.1016/j.omtn.2023.04.019_bib82) 2018; 8
Zeng (10.1016/j.omtn.2023.04.019_bib73) 2017; 9
Perni (10.1016/j.omtn.2023.04.019_bib30) 2021; 11
Lim (10.1016/j.omtn.2023.04.019_bib96) 1999; 121
Mastorakos (10.1016/j.omtn.2023.04.019_bib60) 2016; 12
Niu (10.1016/j.omtn.2023.04.019_bib94) 2020; 58
Pilkington (10.1016/j.omtn.2023.04.019_bib5) 2021; 131
Segovia (10.1016/j.omtn.2023.04.019_bib80) 2015; 4
Green (10.1016/j.omtn.2023.04.019_bib38) 2006; 17
Shenoy (10.1016/j.omtn.2023.04.019_bib10) 2005; 22
Fang (10.1016/j.omtn.2023.04.019_bib4) 2022; 7
Zhang (10.1016/j.omtn.2023.04.019_bib85) 2004; 20
Li (10.1016/j.omtn.2023.04.019_bib92) 2022; 32
Bingol (10.1016/j.omtn.2023.04.019_bib50) 2018; 108
Kaneo (10.1016/j.omtn.2023.04.019_bib57) 2001; 70
Wang (10.1016/j.omtn.2023.04.019_bib56) 2013; 34
Green (10.1016/j.omtn.2023.04.019_bib43) 2007; 19
Akinc (10.1016/j.omtn.2023.04.019_bib33) 2003; 14
Tang (10.1016/j.omtn.2023.04.019_bib62) 2015; 48
McBath (10.1016/j.omtn.2023.04.019_bib79) 2010; 1
Shmueli (10.1016/j.omtn.2023.04.019_bib29) 2013; 34
Chen (10.1016/j.omtn.2023.04.019_bib19) 2007; 48
Galli (10.1016/j.omtn.2023.04.019_bib7) 1983; 4
Liu (10.1016/j.omtn.2023.04.019_bib51) 2018; 15
Anderson (10.1016/j.omtn.2023.04.019_bib25) 2004; 101
Zhang (10.1016/j.omtn.2023.04.019_bib55) 2018; 29
Chen (10.1016/j.omtn.2023.04.019_bib11) 2013; 5
Iqbal (10.1016/j.omtn.2023.04.019_bib17) 2022; 13
Yu (10.1016/j.omtn.2023.04.019_bib75) 2018; 46
Tzeng (10.1016/j.omtn.2023.04.019_bib58) 2013; 2
Rodriguez-Garcia (10.1016/j.omtn.2023.04.019_bib45) 2015; 6
Wang (10.1016/j.omtn.2023.04.019_bib54) 2016; 7
Anderson (10.1016/j.omtn.2023.04.019_bib22) 2003; 42
Wu (10.1016/j.omtn.2023.04.019_bib70) 2006; 7
Chen (10.1016/j.omtn.2023.04.019_bib34) 2012; 22
Bishop (10.1016/j.omtn.2023.04.019_bib88) 2015; 11
Zhang (10.1016/j.omtn.2023.04.019_bib68) 2014; 35
Zugates (10.1016/j.omtn.2023.04.019_bib44) 2007; 18
Perni (10.1016/j.omtn.2023.04.019_bib31) 2017; 13
Cordeiro (10.1016/j.omtn.2023.04.019_bib16) 2019; 310
Liu (10.1016/j.omtn.2023.04.019_bib53) 2017; 3
Wen (10.1016/j.omtn.2023.04.019_bib83) 2018; 4
Cutlar (10.1016/j.omtn.2023.04.019_bib20) 2015; 16
Little (10.1016/j.omtn.2023.04.019_bib89) 2004; 101
Gao (10.1016/j.omtn.2023.04.019_bib66) 2002; 40
Jewell (10.1016/j.omtn.2023.04.019_bib86) 2005; 106
Bardhan (10.1016/j.omtn.2023.04.019_bib6) 2022; 12
Bishop (10.1016/j.omtn.2023.04.019_bib37) 2013; 135
Dosta (10.1016/j.omtn.2023.04.019_bib46) 2015; 20
Wang (10.1016/j.omtn.2023.04.019_bib74) 2020; 38
Iqbal (10.1016/j.omtn.2023.04.019_bib15) 2020; 141
Eltoukhy (10.1016/j.omtn.2023.04.019_bib28) 2012; 33
Dohmen (10.1016/j.omtn.2023.04.019_bib52) 2012; 6
Patil (10.1016/j.omtn.2023.04.019_bib3) 2019; 20
Brey (10.1016/j.omtn.2023.04.019_bib24) 2008; 85
Zhang (10.1016/j.omtn.2023.04.019_bib12) 2014; 3
Chou (10.1016/j.omtn.2023.04.019_bib77) 2021; 135
Tang (10.1016/j.omtn.2023.04.019_bib63) 2016; 26
Wirth (10.1016/j.omtn.2023.04.019_bib1) 2013; 525
Safranski (10.1016/j.omtn.2023.04.019_bib14) 2011; 96
Suk (10.1016/j.omtn.2023.04.019_bib59) 2016; 99
Vázquez (10.1016/j.omtn.2023.04.019_bib84) 2002; 124
Zhong (10.1016/j.omtn.2023.04.019_bib69) 2005; 109
Zhou (10.1016/j.omtn.2023.04.019_bib81) 2019; 19
Xu (10.1016/j.omtn.2023.04.019_bib95) 2018; 9
Kozielski (10.1016/j.omtn.2023.04.019_bib39) 2014; 8
Cordeiro (10.1016/j.omtn.2023.04.019_bib64) 2015; 15
Arote (10.1016/j.omtn.2023.04.019_bib26) 2008; 10
Jere (10.1016/j.omtn.2023.04.019_bib61) 2008; 25
Su (10.1016/j.omtn.2023.04.019_bib90) 2011; 8
Wang (10.1016/j.omtn.2023.04.019_bib76) 2017; 6
Mohammadinejad (10.1016/j.omtn.2023.04.019_bib2) 2020; 325
Gao (10.1016/j.omtn.2023.04.019_bib72) 2016; 17
Lynn (10.1016/j.omtn.2023.04.019_bib35) 2001; 123
Kaczmarek (10.1016/j.omtn.2023.04.019_bib78) 2016; 55
Cordeiro (10.1016/j.omtn.2023.04.019_bib65) 2017; 47
Lynn (10.1016/j.omtn.2023.04.019_bib8) 2000; 122
Liu (10.1016/j.omtn.2023.04.019_bib18) 2009; 20
Lim (10.1016/j.omtn.2023.04.019_bib97) 2000; 122
Jewell (10.1016/j.omtn.2023.04.019_bib87) 2006; 7
Est-Witte (10.1016/j.omtn.2023.04.019_bib93) 2020; 113
Sunshine (10.1016/j.omtn.2023.04.019_bib42) 2009; 21
Jones (10.1016/j.omtn.2023.04.019_bib48) 2015; 16
Liu (10.1016/j.omtn.2023.04.019_bib49) 2019; 10
References_xml – volume: 35
  start-page: 711
  year: 2014
  end-page: 719
  ident: bib68
  article-title: Mussel-inspired hyperbranched poly(amino ester) polymer as strong wet tissue adhesive
  publication-title: Biomaterials
– volume: 8
  start-page: 952
  year: 2018
  ident: bib82
  article-title: pH-Sensitive poly(beta-amino ester)s nanocarriers facilitate the inhibition of drug resistance in breast cancer cells
  publication-title: Nanomaterials
– volume: 131
  start-page: 16
  year: 2021
  end-page: 40
  ident: bib5
  article-title: From influenza to COVID-19: lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases
  publication-title: Acta Biomater.
– volume: 113
  start-page: 279
  year: 2020
  end-page: 288
  ident: bib93
  article-title: Non-viral gene delivery of HIF-1alpha promotes angiogenesis in human adipose-derived stem cells
  publication-title: Acta Biomater.
– volume: 25
  start-page: 875
  year: 2008
  end-page: 885
  ident: bib61
  article-title: Poly (amino ester) composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier
  publication-title: Pharm. Res. (N. Y.)
– volume: 42
  start-page: 3153
  year: 2003
  end-page: 3158
  ident: bib22
  article-title: Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery
  publication-title: Angew. Chem. Int. Ed. Engl.
– volume: 17
  start-page: 3640
  year: 2016
  end-page: 3647
  ident: bib72
  article-title: Highly branched poly(beta-amino esters) for non-viral gene delivery: high transfection efficiency and low toxicity achieved by increasing molecular weight
  publication-title: Biomacromolecules
– volume: 122
  start-page: 10761
  year: 2000
  end-page: 10768
  ident: bib8
  article-title: Degradable poly(β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA
  publication-title: J. Am. Chem. Soc.
– volume: 21
  start-page: 4947
  year: 2009
  end-page: 4951
  ident: bib42
  article-title: Small-molecule end-groups of linear polymer determine cell-type gene-delivery efficacy
  publication-title: Adv. Mater.
– volume: 6
  start-page: 5198
  year: 2012
  end-page: 5208
  ident: bib52
  article-title: Nanosized multifunctional polyplexes for receptor-mediated siRNA delivery
  publication-title: ACS Nano
– volume: 122
  start-page: 6524
  year: 2000
  end-page: 6525
  ident: bib97
  article-title: Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-l-glycolic acid]
  publication-title: J. Am. Chem. Soc.
– volume: 29
  start-page: 325101
  year: 2018
  ident: bib55
  article-title: pH- and redox-responsive nanoparticles composed of charge-reversible pullulan-based shells and disulfide-containing poly(ss-amino ester) cores for co-delivery of a gene and chemotherapeutic agent
  publication-title: Nanotechnology
– volume: 7
  start-page: 94
  year: 2022
  ident: bib4
  article-title: Advances in COVID-19 mRNA vaccine development
  publication-title: Signal Transduct. Target. Ther.
– volume: 3
  start-page: 1283
  year: 2017
  end-page: 1286
  ident: bib53
  article-title: Biodegradable highly branched poly(beta-amino Ester)s for targeted cancer cell gene transfection
  publication-title: ACS Biomater. Sci. Eng.
– volume: 135
  start-page: 6951
  year: 2013
  end-page: 6957
  ident: bib37
  article-title: The effect and role of carbon atoms in poly(beta-amino ester)s for DNA binding and gene delivery
  publication-title: J. Am. Chem. Soc.
– volume: 5
  start-page: 975
  year: 2022
  end-page: 987
  ident: bib98
  article-title: Oral mRNA delivery using capsule-mediated gastrointestinal tissue injections
  publication-title: Matter
– volume: 2
  start-page: e1600102
  year: 2016
  ident: bib32
  article-title: The transition from linear to highly branched poly(beta-amino ester)s: branching matters for gene delivery
  publication-title: Sci. Adv.
– volume: 20
  start-page: 82
  year: 2015
  end-page: 93
  ident: bib46
  article-title: Surface charge tunability as a powerful strategy to control electrostatic interaction for high efficiency silencing, using tailored oligopeptide-modified poly(beta-amino ester)s (PBAEs)
  publication-title: Acta Biomater.
– volume: 34
  start-page: 7181
  year: 2013
  end-page: 7190
  ident: bib56
  article-title: pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma
  publication-title: Biomaterials
– volume: 124
  start-page: 13992
  year: 2002
  end-page: 13993
  ident: bib84
  article-title: Construction of hydrolytically-degradable thin films via layer-by-layer deposition of degradable polyelectrolytes
  publication-title: J. Am. Chem. Soc.
– volume: 8
  start-page: 3232
  year: 2014
  end-page: 3241
  ident: bib39
  article-title: Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells
  publication-title: ACS Nano
– volume: 106
  start-page: 214
  year: 2005
  end-page: 223
  ident: bib86
  article-title: Multilayered polyelectrolyte films promote the direct and localized delivery of DNA to cells
  publication-title: J. Control. Release
– volume: 20
  start-page: 1298
  year: 2012
  end-page: 1304
  ident: bib9
  article-title: In vivo gene delivery by nonviral vectors: overcoming hurdles?
  publication-title: Mol. Ther.
– volume: 9
  start-page: 2179
  year: 2018
  end-page: 2187
  ident: bib95
  article-title: Injectable hyperbranched poly(beta-amino ester) hydrogels with on-demand degradation profiles to match wound healing processes
  publication-title: Chem. Sci.
– volume: 101
  start-page: 9534
  year: 2004
  end-page: 9539
  ident: bib89
  article-title: Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 22
  start-page: 2107
  year: 2005
  end-page: 2114
  ident: bib10
  article-title: Poly(Ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: Part 2. In vivo distribution and tumor localization studies
  publication-title: Pharm. Res. (N. Y.)
– volume: 141
  start-page: 110097
  year: 2020
  ident: bib15
  article-title: Poly (β-amino esters) based potential drug delivery and targeting polymer; an overview and perspectives (review)
  publication-title: Eur. Polym. J.
– volume: 20
  start-page: 5491
  year: 2019
  ident: bib3
  article-title: The development of functional non-viral vectors for gene delivery
  publication-title: Int. J. Mol. Sci.
– volume: 13
  start-page: 854859
  year: 2022
  ident: bib17
  article-title: Synthesis and characterization of poly (beta-amino ester) and applied PEGylated and non-PEGylated poly (beta-amino ester)/plasmid DNA nanoparticles for efficient gene delivery
  publication-title: Front. Pharmacol.
– volume: 13
  start-page: 539
  year: 2017
  end-page: 548
  ident: bib31
  article-title: Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage
  publication-title: Nanomedicine
– volume: 26
  start-page: 6033
  year: 2016
  end-page: 6046
  ident: bib63
  article-title: Tumor-microenvironment-adaptive nanoparticles codeliver paclitaxel and siRNA to inhibit growth and lung metastasis of breast cancer
  publication-title: Adv. Funct. Mater.
– volume: 7
  start-page: 6340
  year: 2016
  end-page: 6353
  ident: bib54
  article-title: Dual-responsive nanoparticles based on oxidized pullulan and a disulfide-containing poly(β-amino) ester for efficient delivery of genes and chemotherapeutic agents targeting hepatoma
  publication-title: Polym. Chem.
– volume: 16
  start-page: 1534
  year: 2015
  end-page: 1541
  ident: bib48
  article-title: Structure-function assessment of mannosylated poly(beta-amino esters) upon targeted antigen presenting cell gene delivery
  publication-title: Biomacromolecules
– volume: 2
  start-page: 468
  year: 2013
  end-page: 480
  ident: bib58
  article-title: Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer
  publication-title: Adv. Healthc. Mater.
– volume: 96
  start-page: 320
  year: 2011
  end-page: 329
  ident: bib14
  article-title: Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(beta-amino ester) networks
  publication-title: J. Biomed. Mater. Res.
– volume: 22
  start-page: 7121
  year: 2012
  end-page: 7129
  ident: bib34
  article-title: Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin
  publication-title: J. Mater. Chem.
– volume: 8
  start-page: 774
  year: 2011
  end-page: 787
  ident: bib90
  article-title: In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles
  publication-title: Mol. Pharm.
– volume: 11
  start-page: 426
  year: 2005
  end-page: 434
  ident: bib23
  article-title: Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters)
  publication-title: Mol. Ther.
– volume: 6
  start-page: 3166
  year: 2005
  end-page: 3173
  ident: bib67
  article-title: Evaluation of hyperbranched poly(amino ester)s of amine constitutions similar to polyethylenimine for DNA delivery
  publication-title: Biomacromolecules
– volume: 70
  start-page: 365
  year: 2001
  end-page: 373
  ident: bib57
  article-title: Evidence for receptor-mediated hepatic uptake of pullulan in rats
  publication-title: J. Control. Release
– volume: 5
  start-page: 3108
  year: 2013
  end-page: 3117
  ident: bib11
  article-title: Photo-cross-linked and pH-sensitive biodegradable micelles for doxorubicin delivery
  publication-title: ACS Appl. Mater. Interfaces
– volume: 17
  start-page: 1162
  year: 2006
  end-page: 1169
  ident: bib38
  article-title: Biodegradable polymeric vectors for gene delivery to human endothelial cells
  publication-title: Bioconjug. Chem.
– volume: 47
  start-page: 113
  year: 2017
  end-page: 123
  ident: bib65
  article-title: High transfection efficiency promoted by tailor-made cationic tri-block copolymer-based nanoparticles
  publication-title: Acta Biomater.
– volume: 20
  start-page: 2317
  year: 2009
  end-page: 2323
  ident: bib18
  article-title: Poly(beta-aminoester)s with pendant primary amines for efficient gene delivery
  publication-title: Bioconjug. Chem.
– volume: 10
  start-page: 1223
  year: 2008
  end-page: 1235
  ident: bib26
  article-title: Biodegradable poly(ester amine) based on glycerol dimethacrylate and polyethylenimine as a gene carrier
  publication-title: J. Gene Med.
– volume: 4
  start-page: 271
  year: 2015
  end-page: 280
  ident: bib80
  article-title: Hydrogel doped with nanoparticles for local sustained release of siRNA in breast cancer
  publication-title: Adv. Healthc. Mater.
– volume: 20
  start-page: 8015
  year: 2004
  end-page: 8021
  ident: bib85
  article-title: Multilayered thin films that sustain the release of functional DNA under physiological conditions
  publication-title: Langmuir
– volume: 39
  start-page: 1793
  year: 2001
  end-page: 1803
  ident: bib41
  article-title: Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century
  publication-title: Toxicon
– volume: 108
  start-page: 57
  year: 2018
  end-page: 68
  ident: bib50
  article-title: Redox-responsive phosphonate-functionalized poly(β-amino ester) gels and cryogels
  publication-title: Eur. Polym. J.
– volume: 15
  start-page: 4558
  year: 2018
  end-page: 4567
  ident: bib51
  article-title: Synthesis and characterization of quaternized poly(beta-amino ester) for highly efficient delivery of small interfering RNA
  publication-title: Mol. Pharm.
– volume: 310
  start-page: 155
  year: 2019
  end-page: 187
  ident: bib16
  article-title: Poly(beta-amino ester)-based gene delivery systems: from discovery to therapeutic applications
  publication-title: J. Control. Release
– volume: 4
  start-page: 4244
  year: 2018
  end-page: 4254
  ident: bib83
  article-title: Near-Infrared/pH dual-sensitive nanocarriers for enhanced intracellular delivery of doxorubicin
  publication-title: ACS Biomater. Sci. Eng.
– volume: 11
  start-page: 7275
  year: 2021
  ident: bib30
  article-title: Amplify antimicrobial photo dynamic therapy efficacy with poly-beta-amino esters (PBAEs)
  publication-title: Sci. Rep.
– volume: 19
  start-page: 3671
  year: 2019
  end-page: 3675
  ident: bib81
  article-title: Light-Triggered PEGylation/dePEGylation of the nanocarriers for enhanced tumor penetration
  publication-title: Nano Lett.
– volume: 55
  start-page: 13808
  year: 2016
  end-page: 13812
  ident: bib78
  article-title: Polymer-lipid nanoparticles for systemic delivery of mRNA to the lungs
  publication-title: Angew. Chem. Int. Ed. Engl.
– volume: 10
  start-page: 2921
  year: 2009
  end-page: 2927
  ident: bib21
  article-title: Bioreducible hyperbranched poly(amido amine)s for gene delivery
  publication-title: Biomacromolecules
– volume: 135
  start-page: 331
  year: 2021
  end-page: 341
  ident: bib77
  article-title: A design approach for layer-by-layer surface-mediated siRNA delivery
  publication-title: Acta Biomater.
– volume: 3
  start-page: 693
  year: 2014
  end-page: 697
  ident: bib12
  article-title: Trigger-responsive poly(beta-amino ester) hydrogels
  publication-title: ACS Macro Lett.
– volume: 8
  start-page: 290
  year: 2020
  end-page: 301
  ident: bib40
  article-title: Topology-assisted, photo-strengthened DNA/siRNA delivery mediated by branched poly(beta-amino ester)s via synchronized intracellular kinetics
  publication-title: Biomater. Sci.
– volume: 40
  start-page: 2340
  year: 2002
  end-page: 2349
  ident: bib66
  article-title: Synthesis and characterization of water-soluble hyperbranched poly(ester amine)s from diacrylates and diamines
  publication-title: J. Polym. Sci. A. Polym. Chem.
– volume: 46
  start-page: 323
  year: 2018
  end-page: 332
  ident: bib75
  article-title: Lipid nanoparticle-based co-delivery of epirubicin and BCL-2 siRNA for enhanced intracellular drug release and reversing multidrug resistance
  publication-title: Artif. Cells Nanomed. Biotechnol.
– volume: 11
  start-page: 393
  year: 2015
  end-page: 403
  ident: bib88
  article-title: Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA
  publication-title: Acta Biomater.
– volume: 32
  start-page: 2204462
  year: 2022
  ident: bib92
  article-title: Lipid-polymer hybrid "Particle-in-Particle" nanostructure gene delivery platform explored for lyophilizable DNA and mRNA COVID-19 vaccines
  publication-title: Adv. Funct. Mater.
– volume: 14
  start-page: 979
  year: 2003
  end-page: 988
  ident: bib33
  article-title: Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery
  publication-title: Bioconjug. Chem.
– volume: 33
  start-page: 3594
  year: 2012
  end-page: 3603
  ident: bib28
  article-title: Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity
  publication-title: Biomaterials
– volume: 13
  start-page: 1038
  year: 1996
  end-page: 1042
  ident: bib36
  article-title: Effect of size and serum proteins on transfection efficiency of poly ((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles
  publication-title: Pharm. Res. (N. Y.)
– volume: 58
  start-page: 102897
  year: 2020
  ident: bib94
  article-title: An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (beta-amino ester) nanoparticles for vaginal gene therapy
  publication-title: EBioMedicine
– volume: 1
  start-page: 860
  year: 2010
  end-page: 865
  ident: bib79
  article-title: Swelling and degradation of hydrogels synthesized with degradable poly(β-amino ester) crosslinkers
  publication-title: Polym. Chem.
– volume: 125
  start-page: 81
  year: 2017
  end-page: 89
  ident: bib91
  article-title: Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination
  publication-title: Biomaterials
– volume: 109
  start-page: 317
  year: 2005
  end-page: 329
  ident: bib69
  article-title: A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s
  publication-title: J. Control. Release
– volume: 48
  start-page: 1
  year: 2015
  end-page: 15
  ident: bib62
  article-title: Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (beta-amino ester) nanoparticles co-delivering two siRNA and paclitaxel
  publication-title: Biomaterials
– volume: 6
  start-page: 1601041
  year: 2017
  ident: bib76
  article-title: Engineered hydrogels for local and sustained delivery of RNA-interference therapies
  publication-title: Adv. Healthc. Mater.
– volume: 6
  start-page: 8385
  year: 2015
  ident: bib45
  article-title: Formation of oligopeptides in high yield under simple programmable conditions
  publication-title: Nat. Commun.
– volume: 121
  start-page: 5633
  year: 1999
  end-page: 5639
  ident: bib96
  article-title: A self-destroying polycationic polymer: biodegradable poly(4-hydroxy-l-proline ester)
  publication-title: J. Am. Chem. Soc.
– volume: 123
  start-page: 8155
  year: 2001
  end-page: 8156
  ident: bib35
  article-title: Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library
  publication-title: J. Am. Chem. Soc.
– volume: 10
  start-page: 3307
  year: 2019
  ident: bib49
  article-title: Highly branched poly(beta-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
  publication-title: Nat. Commun.
– volume: 15
  start-page: 215
  year: 2015
  end-page: 228
  ident: bib64
  article-title: Novel cationic triblock copolymer of poly[2-(dimethylamino)ethyl methacrylate]-block-poly(beta-amino ester)-block-poly[2-(dimethylamino)ethyl methacrylate]: a promising non-viral gene delivery system
  publication-title: Macromol. Biosci.
– volume: 128
  start-page: 12726
  year: 2006
  end-page: 12734
  ident: bib27
  article-title: Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery
  publication-title: J. Am. Chem. Soc.
– volume: 19
  start-page: 2836
  year: 2007
  end-page: 2842
  ident: bib43
  article-title: Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus
  publication-title: Adv. Mater.
– volume: 12
  start-page: 1119
  year: 2022
  end-page: 1139
  ident: bib6
  article-title: Nanomaterials in diagnostics, imaging and delivery: applications from COVID-19 to cancer
  publication-title: MRS Commun.
– volume: 16
  start-page: 2609
  year: 2015
  end-page: 2617
  ident: bib20
  article-title: Highly branched poly(beta-amino esters): synthesis and application in gene delivery
  publication-title: Biomacromolecules
– volume: 38
  start-page: 830
  year: 2020
  end-page: 839
  ident: bib74
  article-title: Effects of branching strategy on the gene transfection of highly branched poly(β-amino ester)s
  publication-title: Chin. J. Polym. Sci.
– volume: 37
  start-page: 333
  year: 2015
  end-page: 344
  ident: bib47
  article-title: Mannosylated poly(beta-amino esters) for targeted antigen presenting cell immune modulation
  publication-title: Biomaterials
– volume: 34
  start-page: 7544
  year: 2013
  end-page: 7551
  ident: bib29
  article-title: Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide
  publication-title: Biomaterials
– volume: 135
  start-page: 7847
  year: 2013
  end-page: 7850
  ident: bib13
  article-title: Collective activation of MRI agents via encapsulation and disease-triggered release
  publication-title: J. Am. Chem. Soc.
– volume: 48
  start-page: 675
  year: 2007
  end-page: 681
  ident: bib19
  article-title: Synthesis and degradation of poly(beta-aminoester) with pendant primary amine
  publication-title: Polymer
– volume: 525
  start-page: 162
  year: 2013
  end-page: 169
  ident: bib1
  article-title: History of gene therapy
  publication-title: Gene
– volume: 18
  start-page: 1887
  year: 2007
  end-page: 1896
  ident: bib44
  article-title: Gene delivery properties of end-modified poly(beta-amino ester)s
  publication-title: Bioconjug. Chem.
– volume: 9
  start-page: 161
  year: 2017
  ident: bib73
  article-title: Highly branched poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) for high performance gene transfection
  publication-title: Polymers
– volume: 7
  start-page: 1879
  year: 2006
  end-page: 1883
  ident: bib70
  article-title: Hyperbranched poly(amino ester)s with different terminal amine groups for DNA delivery
  publication-title: Biomacromolecules
– volume: 325
  start-page: 249
  year: 2020
  end-page: 275
  ident: bib2
  article-title: In vivo gene delivery mediated by non-viral vectors for cancer therapy
  publication-title: J. Control. Release
– volume: 4
  start-page: 681
  year: 1983
  end-page: 686
  ident: bib7
  article-title: Thermotropic poly(β-aminoester)s containing azoxy groups
  publication-title: Die Makromol. Chem. Rapid Commun.
– volume: 99
  start-page: 28
  year: 2016
  end-page: 51
  ident: bib59
  article-title: PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 85
  start-page: 731
  year: 2008
  end-page: 741
  ident: bib24
  article-title: Influence of macromer molecular weight and chemistry on poly(beta-amino ester) network properties and initial cell interactions
  publication-title: J. Biomed. Mater. Res. A
– volume: 12
  start-page: 678
  year: 2016
  end-page: 685
  ident: bib60
  article-title: Biodegradable DNA nanoparticles that provide widespread gene delivery in the brain
  publication-title: Small
– volume: 101
  start-page: 16028
  year: 2004
  end-page: 16033
  ident: bib25
  article-title: A polymer library approach to suicide gene therapy for cancer
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 244
  start-page: 336
  year: 2016
  end-page: 346
  ident: bib71
  article-title: Highly branched poly(beta-amino ester)s for skin gene therapy
  publication-title: J. Control. Release
– volume: 7
  start-page: 2483
  year: 2006
  end-page: 2491
  ident: bib87
  article-title: Release of plasmid DNA from intravascular stents coated with ultrathin multilayered polyelectrolyte films
  publication-title: Biomacromolecules
– volume: 10
  start-page: 3307
  year: 2019
  ident: 10.1016/j.omtn.2023.04.019_bib49
  article-title: Highly branched poly(beta-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-11190-0
– volume: 6
  start-page: 8385
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib45
  article-title: Formation of oligopeptides in high yield under simple programmable conditions
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9385
– volume: 20
  start-page: 5491
  year: 2019
  ident: 10.1016/j.omtn.2023.04.019_bib3
  article-title: The development of functional non-viral vectors for gene delivery
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms20215491
– volume: 14
  start-page: 979
  year: 2003
  ident: 10.1016/j.omtn.2023.04.019_bib33
  article-title: Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery
  publication-title: Bioconjug. Chem.
  doi: 10.1021/bc034067y
– volume: 26
  start-page: 6033
  year: 2016
  ident: 10.1016/j.omtn.2023.04.019_bib63
  article-title: Tumor-microenvironment-adaptive nanoparticles codeliver paclitaxel and siRNA to inhibit growth and lung metastasis of breast cancer
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201601703
– volume: 37
  start-page: 333
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib47
  article-title: Mannosylated poly(beta-amino esters) for targeted antigen presenting cell immune modulation
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2014.10.037
– volume: 11
  start-page: 7275
  year: 2021
  ident: 10.1016/j.omtn.2023.04.019_bib30
  article-title: Amplify antimicrobial photo dynamic therapy efficacy with poly-beta-amino esters (PBAEs)
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-86773-3
– volume: 16
  start-page: 1534
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib48
  article-title: Structure-function assessment of mannosylated poly(beta-amino esters) upon targeted antigen presenting cell gene delivery
  publication-title: Biomacromolecules
  doi: 10.1021/acs.biomac.5b00062
– volume: 6
  start-page: 3166
  year: 2005
  ident: 10.1016/j.omtn.2023.04.019_bib67
  article-title: Evaluation of hyperbranched poly(amino ester)s of amine constitutions similar to polyethylenimine for DNA delivery
  publication-title: Biomacromolecules
  doi: 10.1021/bm0504983
– volume: 124
  start-page: 13992
  year: 2002
  ident: 10.1016/j.omtn.2023.04.019_bib84
  article-title: Construction of hydrolytically-degradable thin films via layer-by-layer deposition of degradable polyelectrolytes
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja026405w
– volume: 18
  start-page: 1887
  year: 2007
  ident: 10.1016/j.omtn.2023.04.019_bib44
  article-title: Gene delivery properties of end-modified poly(beta-amino ester)s
  publication-title: Bioconjug. Chem.
  doi: 10.1021/bc7002082
– volume: 20
  start-page: 8015
  year: 2004
  ident: 10.1016/j.omtn.2023.04.019_bib85
  article-title: Multilayered thin films that sustain the release of functional DNA under physiological conditions
  publication-title: Langmuir
  doi: 10.1021/la048888i
– volume: 17
  start-page: 1162
  year: 2006
  ident: 10.1016/j.omtn.2023.04.019_bib38
  article-title: Biodegradable polymeric vectors for gene delivery to human endothelial cells
  publication-title: Bioconjug. Chem.
  doi: 10.1021/bc0600968
– volume: 9
  start-page: 2179
  year: 2018
  ident: 10.1016/j.omtn.2023.04.019_bib95
  article-title: Injectable hyperbranched poly(beta-amino ester) hydrogels with on-demand degradation profiles to match wound healing processes
  publication-title: Chem. Sci.
  doi: 10.1039/C7SC03913A
– volume: 12
  start-page: 1119
  year: 2022
  ident: 10.1016/j.omtn.2023.04.019_bib6
  article-title: Nanomaterials in diagnostics, imaging and delivery: applications from COVID-19 to cancer
  publication-title: MRS Commun.
  doi: 10.1557/s43579-022-00257-7
– volume: 32
  start-page: 2204462
  year: 2022
  ident: 10.1016/j.omtn.2023.04.019_bib92
  article-title: Lipid-polymer hybrid "Particle-in-Particle" nanostructure gene delivery platform explored for lyophilizable DNA and mRNA COVID-19 vaccines
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.202204462
– volume: 106
  start-page: 214
  year: 2005
  ident: 10.1016/j.omtn.2023.04.019_bib86
  article-title: Multilayered polyelectrolyte films promote the direct and localized delivery of DNA to cells
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2005.04.014
– volume: 22
  start-page: 2107
  year: 2005
  ident: 10.1016/j.omtn.2023.04.019_bib10
  article-title: Poly(Ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: Part 2. In vivo distribution and tumor localization studies
  publication-title: Pharm. Res. (N. Y.)
  doi: 10.1007/s11095-005-8343-0
– volume: 70
  start-page: 365
  year: 2001
  ident: 10.1016/j.omtn.2023.04.019_bib57
  article-title: Evidence for receptor-mediated hepatic uptake of pullulan in rats
  publication-title: J. Control. Release
  doi: 10.1016/S0168-3659(00)00368-0
– volume: 96
  start-page: 320
  year: 2011
  ident: 10.1016/j.omtn.2023.04.019_bib14
  article-title: Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(beta-amino ester) networks
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/jbm.a.32983
– volume: 310
  start-page: 155
  year: 2019
  ident: 10.1016/j.omtn.2023.04.019_bib16
  article-title: Poly(beta-amino ester)-based gene delivery systems: from discovery to therapeutic applications
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2019.08.024
– volume: 19
  start-page: 3671
  year: 2019
  ident: 10.1016/j.omtn.2023.04.019_bib81
  article-title: Light-Triggered PEGylation/dePEGylation of the nanocarriers for enhanced tumor penetration
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.9b00737
– volume: 17
  start-page: 3640
  year: 2016
  ident: 10.1016/j.omtn.2023.04.019_bib72
  article-title: Highly branched poly(beta-amino esters) for non-viral gene delivery: high transfection efficiency and low toxicity achieved by increasing molecular weight
  publication-title: Biomacromolecules
  doi: 10.1021/acs.biomac.6b01120
– volume: 9
  start-page: 161
  year: 2017
  ident: 10.1016/j.omtn.2023.04.019_bib73
  article-title: Highly branched poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) for high performance gene transfection
  publication-title: Polymers
  doi: 10.3390/polym9050161
– volume: 109
  start-page: 317
  year: 2005
  ident: 10.1016/j.omtn.2023.04.019_bib69
  article-title: A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2005.06.022
– volume: 22
  start-page: 7121
  year: 2012
  ident: 10.1016/j.omtn.2023.04.019_bib34
  article-title: Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin
  publication-title: J. Mater. Chem.
  doi: 10.1039/c2jm15277k
– volume: 325
  start-page: 249
  year: 2020
  ident: 10.1016/j.omtn.2023.04.019_bib2
  article-title: In vivo gene delivery mediated by non-viral vectors for cancer therapy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2020.06.038
– volume: 2
  start-page: e1600102
  year: 2016
  ident: 10.1016/j.omtn.2023.04.019_bib32
  article-title: The transition from linear to highly branched poly(beta-amino ester)s: branching matters for gene delivery
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.1600102
– volume: 123
  start-page: 8155
  year: 2001
  ident: 10.1016/j.omtn.2023.04.019_bib35
  article-title: Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja016288p
– volume: 38
  start-page: 830
  year: 2020
  ident: 10.1016/j.omtn.2023.04.019_bib74
  article-title: Effects of branching strategy on the gene transfection of highly branched poly(β-amino ester)s
  publication-title: Chin. J. Polym. Sci.
  doi: 10.1007/s10118-020-2393-y
– volume: 8
  start-page: 290
  year: 2020
  ident: 10.1016/j.omtn.2023.04.019_bib40
  article-title: Topology-assisted, photo-strengthened DNA/siRNA delivery mediated by branched poly(beta-amino ester)s via synchronized intracellular kinetics
  publication-title: Biomater. Sci.
  doi: 10.1039/C9BM01452G
– volume: 113
  start-page: 279
  year: 2020
  ident: 10.1016/j.omtn.2023.04.019_bib93
  article-title: Non-viral gene delivery of HIF-1alpha promotes angiogenesis in human adipose-derived stem cells
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2020.06.042
– volume: 5
  start-page: 975
  year: 2022
  ident: 10.1016/j.omtn.2023.04.019_bib98
  article-title: Oral mRNA delivery using capsule-mediated gastrointestinal tissue injections
  publication-title: Matter
  doi: 10.1016/j.matt.2021.12.022
– volume: 122
  start-page: 6524
  year: 2000
  ident: 10.1016/j.omtn.2023.04.019_bib97
  article-title: Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-l-glycolic acid]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja001033h
– volume: 13
  start-page: 1038
  year: 1996
  ident: 10.1016/j.omtn.2023.04.019_bib36
  article-title: Effect of size and serum proteins on transfection efficiency of poly ((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles
  publication-title: Pharm. Res. (N. Y.)
  doi: 10.1023/A:1016054623543
– volume: 11
  start-page: 426
  year: 2005
  ident: 10.1016/j.omtn.2023.04.019_bib23
  article-title: Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters)
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2004.11.015
– volume: 135
  start-page: 7847
  year: 2013
  ident: 10.1016/j.omtn.2023.04.019_bib13
  article-title: Collective activation of MRI agents via encapsulation and disease-triggered release
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja403167p
– volume: 16
  start-page: 2609
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib20
  article-title: Highly branched poly(beta-amino esters): synthesis and application in gene delivery
  publication-title: Biomacromolecules
  doi: 10.1021/acs.biomac.5b00966
– volume: 85
  start-page: 731
  year: 2008
  ident: 10.1016/j.omtn.2023.04.019_bib24
  article-title: Influence of macromer molecular weight and chemistry on poly(beta-amino ester) network properties and initial cell interactions
  publication-title: J. Biomed. Mater. Res. A
  doi: 10.1002/jbm.a.31494
– volume: 33
  start-page: 3594
  year: 2012
  ident: 10.1016/j.omtn.2023.04.019_bib28
  article-title: Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.01.046
– volume: 141
  start-page: 110097
  year: 2020
  ident: 10.1016/j.omtn.2023.04.019_bib15
  article-title: Poly (β-amino esters) based potential drug delivery and targeting polymer; an overview and perspectives (review)
  publication-title: Eur. Polym. J.
  doi: 10.1016/j.eurpolymj.2020.110097
– volume: 101
  start-page: 9534
  year: 2004
  ident: 10.1016/j.omtn.2023.04.019_bib89
  article-title: Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0403549101
– volume: 125
  start-page: 81
  year: 2017
  ident: 10.1016/j.omtn.2023.04.019_bib91
  article-title: Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2017.02.019
– volume: 21
  start-page: 4947
  year: 2009
  ident: 10.1016/j.omtn.2023.04.019_bib42
  article-title: Small-molecule end-groups of linear polymer determine cell-type gene-delivery efficacy
  publication-title: Adv. Mater.
  doi: 10.1002/adma.200901718
– volume: 7
  start-page: 94
  year: 2022
  ident: 10.1016/j.omtn.2023.04.019_bib4
  article-title: Advances in COVID-19 mRNA vaccine development
  publication-title: Signal Transduct. Target. Ther.
  doi: 10.1038/s41392-022-00950-y
– volume: 131
  start-page: 16
  year: 2021
  ident: 10.1016/j.omtn.2023.04.019_bib5
  article-title: From influenza to COVID-19: lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2021.06.023
– volume: 35
  start-page: 711
  year: 2014
  ident: 10.1016/j.omtn.2023.04.019_bib68
  article-title: Mussel-inspired hyperbranched poly(amino ester) polymer as strong wet tissue adhesive
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.10.017
– volume: 6
  start-page: 5198
  year: 2012
  ident: 10.1016/j.omtn.2023.04.019_bib52
  article-title: Nanosized multifunctional polyplexes for receptor-mediated siRNA delivery
  publication-title: ACS Nano
  doi: 10.1021/nn300960m
– volume: 20
  start-page: 82
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib46
  article-title: Surface charge tunability as a powerful strategy to control electrostatic interaction for high efficiency silencing, using tailored oligopeptide-modified poly(beta-amino ester)s (PBAEs)
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2015.03.029
– volume: 48
  start-page: 1
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib62
  article-title: Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (beta-amino ester) nanoparticles co-delivering two siRNA and paclitaxel
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2015.01.049
– volume: 47
  start-page: 113
  year: 2017
  ident: 10.1016/j.omtn.2023.04.019_bib65
  article-title: High transfection efficiency promoted by tailor-made cationic tri-block copolymer-based nanoparticles
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2016.10.015
– volume: 101
  start-page: 16028
  year: 2004
  ident: 10.1016/j.omtn.2023.04.019_bib25
  article-title: A polymer library approach to suicide gene therapy for cancer
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0407218101
– volume: 34
  start-page: 7181
  year: 2013
  ident: 10.1016/j.omtn.2023.04.019_bib56
  article-title: pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.05.081
– volume: 7
  start-page: 1879
  year: 2006
  ident: 10.1016/j.omtn.2023.04.019_bib70
  article-title: Hyperbranched poly(amino ester)s with different terminal amine groups for DNA delivery
  publication-title: Biomacromolecules
  doi: 10.1021/bm0601878
– volume: 25
  start-page: 875
  year: 2008
  ident: 10.1016/j.omtn.2023.04.019_bib61
  article-title: Poly (amino ester) composed of poly (ethylene glycol) and aminosilane prepared by combinatorial chemistry as a gene carrier
  publication-title: Pharm. Res. (N. Y.)
  doi: 10.1007/s11095-007-9448-4
– volume: 15
  start-page: 215
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib64
  article-title: Novel cationic triblock copolymer of poly[2-(dimethylamino)ethyl methacrylate]-block-poly(beta-amino ester)-block-poly[2-(dimethylamino)ethyl methacrylate]: a promising non-viral gene delivery system
  publication-title: Macromol. Biosci.
  doi: 10.1002/mabi.201400424
– volume: 1
  start-page: 860
  year: 2010
  ident: 10.1016/j.omtn.2023.04.019_bib79
  article-title: Swelling and degradation of hydrogels synthesized with degradable poly(β-amino ester) crosslinkers
  publication-title: Polym. Chem.
  doi: 10.1039/c0py00074d
– volume: 135
  start-page: 331
  year: 2021
  ident: 10.1016/j.omtn.2023.04.019_bib77
  article-title: A design approach for layer-by-layer surface-mediated siRNA delivery
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2021.08.042
– volume: 122
  start-page: 10761
  year: 2000
  ident: 10.1016/j.omtn.2023.04.019_bib8
  article-title: Degradable poly(β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0015388
– volume: 10
  start-page: 2921
  year: 2009
  ident: 10.1016/j.omtn.2023.04.019_bib21
  article-title: Bioreducible hyperbranched poly(amido amine)s for gene delivery
  publication-title: Biomacromolecules
  doi: 10.1021/bm900724c
– volume: 8
  start-page: 774
  year: 2011
  ident: 10.1016/j.omtn.2023.04.019_bib90
  article-title: In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles
  publication-title: Mol. Pharm.
  doi: 10.1021/mp100390w
– volume: 128
  start-page: 12726
  year: 2006
  ident: 10.1016/j.omtn.2023.04.019_bib27
  article-title: Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja061570n
– volume: 11
  start-page: 393
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib88
  article-title: Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2014.09.020
– volume: 3
  start-page: 1283
  year: 2017
  ident: 10.1016/j.omtn.2023.04.019_bib53
  article-title: Biodegradable highly branched poly(beta-amino Ester)s for targeted cancer cell gene transfection
  publication-title: ACS Biomater. Sci. Eng.
  doi: 10.1021/acsbiomaterials.6b00503
– volume: 244
  start-page: 336
  year: 2016
  ident: 10.1016/j.omtn.2023.04.019_bib71
  article-title: Highly branched poly(beta-amino ester)s for skin gene therapy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2016.06.014
– volume: 121
  start-page: 5633
  year: 1999
  ident: 10.1016/j.omtn.2023.04.019_bib96
  article-title: A self-destroying polycationic polymer: biodegradable poly(4-hydroxy-l-proline ester)
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja984012k
– volume: 4
  start-page: 681
  year: 1983
  ident: 10.1016/j.omtn.2023.04.019_bib7
  article-title: Thermotropic poly(β-aminoester)s containing azoxy groups
  publication-title: Die Makromol. Chem. Rapid Commun.
  doi: 10.1002/marc.1983.030041009
– volume: 29
  start-page: 325101
  year: 2018
  ident: 10.1016/j.omtn.2023.04.019_bib55
  article-title: pH- and redox-responsive nanoparticles composed of charge-reversible pullulan-based shells and disulfide-containing poly(ss-amino ester) cores for co-delivery of a gene and chemotherapeutic agent
  publication-title: Nanotechnology
  doi: 10.1088/1361-6528/aac4b5
– volume: 7
  start-page: 2483
  year: 2006
  ident: 10.1016/j.omtn.2023.04.019_bib87
  article-title: Release of plasmid DNA from intravascular stents coated with ultrathin multilayered polyelectrolyte films
  publication-title: Biomacromolecules
  doi: 10.1021/bm0604808
– volume: 2
  start-page: 468
  year: 2013
  ident: 10.1016/j.omtn.2023.04.019_bib58
  article-title: Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201200257
– volume: 5
  start-page: 3108
  year: 2013
  ident: 10.1016/j.omtn.2023.04.019_bib11
  article-title: Photo-cross-linked and pH-sensitive biodegradable micelles for doxorubicin delivery
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/am400017q
– volume: 3
  start-page: 693
  year: 2014
  ident: 10.1016/j.omtn.2023.04.019_bib12
  article-title: Trigger-responsive poly(beta-amino ester) hydrogels
  publication-title: ACS Macro Lett.
  doi: 10.1021/mz500277j
– volume: 7
  start-page: 6340
  year: 2016
  ident: 10.1016/j.omtn.2023.04.019_bib54
  article-title: Dual-responsive nanoparticles based on oxidized pullulan and a disulfide-containing poly(β-amino) ester for efficient delivery of genes and chemotherapeutic agents targeting hepatoma
  publication-title: Polym. Chem.
  doi: 10.1039/C6PY01664B
– volume: 8
  start-page: 3232
  year: 2014
  ident: 10.1016/j.omtn.2023.04.019_bib39
  article-title: Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells
  publication-title: ACS Nano
  doi: 10.1021/nn500704t
– volume: 39
  start-page: 1793
  year: 2001
  ident: 10.1016/j.omtn.2023.04.019_bib41
  article-title: Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century
  publication-title: Toxicon
  doi: 10.1016/S0041-0101(01)00165-9
– volume: 19
  start-page: 2836
  year: 2007
  ident: 10.1016/j.omtn.2023.04.019_bib43
  article-title: Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus
  publication-title: Adv. Mater.
  doi: 10.1002/adma.200700371
– volume: 13
  start-page: 539
  year: 2017
  ident: 10.1016/j.omtn.2023.04.019_bib31
  article-title: Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2016.10.001
– volume: 58
  start-page: 102897
  year: 2020
  ident: 10.1016/j.omtn.2023.04.019_bib94
  article-title: An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (beta-amino ester) nanoparticles for vaginal gene therapy
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2020.102897
– volume: 10
  start-page: 1223
  year: 2008
  ident: 10.1016/j.omtn.2023.04.019_bib26
  article-title: Biodegradable poly(ester amine) based on glycerol dimethacrylate and polyethylenimine as a gene carrier
  publication-title: J. Gene Med.
  doi: 10.1002/jgm.1252
– volume: 40
  start-page: 2340
  year: 2002
  ident: 10.1016/j.omtn.2023.04.019_bib66
  article-title: Synthesis and characterization of water-soluble hyperbranched poly(ester amine)s from diacrylates and diamines
  publication-title: J. Polym. Sci. A. Polym. Chem.
  doi: 10.1002/pola.10322
– volume: 6
  start-page: 1601041
  year: 2017
  ident: 10.1016/j.omtn.2023.04.019_bib76
  article-title: Engineered hydrogels for local and sustained delivery of RNA-interference therapies
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201601041
– volume: 8
  start-page: 952
  year: 2018
  ident: 10.1016/j.omtn.2023.04.019_bib82
  article-title: pH-Sensitive poly(beta-amino ester)s nanocarriers facilitate the inhibition of drug resistance in breast cancer cells
  publication-title: Nanomaterials
  doi: 10.3390/nano8110952
– volume: 34
  start-page: 7544
  year: 2013
  ident: 10.1016/j.omtn.2023.04.019_bib29
  article-title: Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.06.044
– volume: 4
  start-page: 4244
  year: 2018
  ident: 10.1016/j.omtn.2023.04.019_bib83
  article-title: Near-Infrared/pH dual-sensitive nanocarriers for enhanced intracellular delivery of doxorubicin
  publication-title: ACS Biomater. Sci. Eng.
  doi: 10.1021/acsbiomaterials.8b01051
– volume: 135
  start-page: 6951
  year: 2013
  ident: 10.1016/j.omtn.2023.04.019_bib37
  article-title: The effect and role of carbon atoms in poly(beta-amino ester)s for DNA binding and gene delivery
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja4002376
– volume: 12
  start-page: 678
  year: 2016
  ident: 10.1016/j.omtn.2023.04.019_bib60
  article-title: Biodegradable DNA nanoparticles that provide widespread gene delivery in the brain
  publication-title: Small
  doi: 10.1002/smll.201502554
– volume: 13
  start-page: 854859
  year: 2022
  ident: 10.1016/j.omtn.2023.04.019_bib17
  article-title: Synthesis and characterization of poly (beta-amino ester) and applied PEGylated and non-PEGylated poly (beta-amino ester)/plasmid DNA nanoparticles for efficient gene delivery
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2022.854859
– volume: 525
  start-page: 162
  year: 2013
  ident: 10.1016/j.omtn.2023.04.019_bib1
  article-title: History of gene therapy
  publication-title: Gene
  doi: 10.1016/j.gene.2013.03.137
– volume: 108
  start-page: 57
  year: 2018
  ident: 10.1016/j.omtn.2023.04.019_bib50
  article-title: Redox-responsive phosphonate-functionalized poly(β-amino ester) gels and cryogels
  publication-title: Eur. Polym. J.
  doi: 10.1016/j.eurpolymj.2018.08.029
– volume: 42
  start-page: 3153
  year: 2003
  ident: 10.1016/j.omtn.2023.04.019_bib22
  article-title: Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.200351244
– volume: 99
  start-page: 28
  year: 2016
  ident: 10.1016/j.omtn.2023.04.019_bib59
  article-title: PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2015.09.012
– volume: 20
  start-page: 2317
  year: 2009
  ident: 10.1016/j.omtn.2023.04.019_bib18
  article-title: Poly(beta-aminoester)s with pendant primary amines for efficient gene delivery
  publication-title: Bioconjug. Chem.
  doi: 10.1021/bc900317m
– volume: 15
  start-page: 4558
  year: 2018
  ident: 10.1016/j.omtn.2023.04.019_bib51
  article-title: Synthesis and characterization of quaternized poly(beta-amino ester) for highly efficient delivery of small interfering RNA
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.8b00549
– volume: 55
  start-page: 13808
  year: 2016
  ident: 10.1016/j.omtn.2023.04.019_bib78
  article-title: Polymer-lipid nanoparticles for systemic delivery of mRNA to the lungs
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.201608450
– volume: 46
  start-page: 323
  year: 2018
  ident: 10.1016/j.omtn.2023.04.019_bib75
  article-title: Lipid nanoparticle-based co-delivery of epirubicin and BCL-2 siRNA for enhanced intracellular drug release and reversing multidrug resistance
  publication-title: Artif. Cells Nanomed. Biotechnol.
  doi: 10.1080/21691401.2017.1307215
– volume: 48
  start-page: 675
  year: 2007
  ident: 10.1016/j.omtn.2023.04.019_bib19
  article-title: Synthesis and degradation of poly(beta-aminoester) with pendant primary amine
  publication-title: Polymer
  doi: 10.1016/j.polymer.2006.12.008
– volume: 20
  start-page: 1298
  year: 2012
  ident: 10.1016/j.omtn.2023.04.019_bib9
  article-title: In vivo gene delivery by nonviral vectors: overcoming hurdles?
  publication-title: Mol. Ther.
  doi: 10.1038/mt.2012.79
– volume: 4
  start-page: 271
  year: 2015
  ident: 10.1016/j.omtn.2023.04.019_bib80
  article-title: Hydrogel doped with nanoparticles for local sustained release of siRNA in breast cancer
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201400235
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Snippet The first poly(β-amino) esters (PβAEs) were synthesized more than 40 years ago. Since 2000, PβAEs have been found to have excellent biocompatibility and the...
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SubjectTerms gene delivery
MT: Delivery Strategies
Poly(β-amino) esters (PβAEs)
polymer
Review
vaccines
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Title Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery
URI https://dx.doi.org/10.1016/j.omtn.2023.04.019
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