3-D multi-electrode arrays detect early spontaneous electrophysiological activity in 3-D neuronal-astrocytic co-cultures

• Published in: Biomedical engineering letters Vol. 10; no. 4; pp. 579 - 591
• Main Authors: Vernekar, Varadraj N., LaPlaca, Michelle C.
• Format: Journal Article
• Language: English
• Published: Korea The Korean Society of Medical and Biological Engineering 01.11.2020; Springer Nature B.V; 대한의용생체공학회
• Subjects: Arrays; Axonogenesis; Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Bursts; Cell culture; Cell density; Density; Drug screening; Electrodes; Electrophysiology; Engineering; Firing pattern; Immunocytochemistry; Maturation; Medical and Radiation Physics; Neural networks; Original; Original Article; Recording; Spikes; Synapses; Synaptic density; Synaptogenesis; 의공학; Synapse; Neuron; Three-dimensional; Matrigel; Electrophysiology; MEA; Astrocyte; Multi-electrode array; In vitro; Culture

Three-dimensional (3-D) neural cultures represent a promising platform for studying disease and drug screening. Tools and methodologies for measuring the electrophysiological function in these cultures are needed. Therefore, the purpose of this work was primarily to develop a methodology to interfac...