Relations of Changes in Serum Carcinoembryonic Antigen Levels before and after Neoadjuvant Chemoradiotherapy and after Surgery to Histologic Response and Outcomes in Patients with Locally Advanced Rectal Cancer

• Published in: Oncology Vol. 94; no. 3; pp. 167 - 175
• Main Authors: Saito, Gota, Sadahiro, Sotaro, Ogimi, Takashi, Miyakita, Hiroshi, Okada, Kazutake, Tanaka, Akira, Suzuki, Toshiyuki
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2018
• Subjects: Clinical Study; Carcinoembryonic antigen; Rectal cancer; Overall survival; Chemoradiotherapy; Disease-free survival; Histologic response

Objectives: The histologic response to neoadjuvant chemoradiotherapy (nCRT) has been intimately related to outcomes in locally advanced rectal cancer. Serum carcinoembryonic antigen (CEA) levels change after nCRT and after surgery as compared with before nCRT. Methods: The subjects were 149 patients...