Inhibiting retinoic acid signaling in dendritic cells suppresses respiratory syncytial virus infection through enhanced antiviral immunity

• Published in: iScience Vol. 27; no. 7; p. 110103
• Main Authors: Farazuddin, Mohammad, Acker, Grant, Zourob, Joseph, O’Konek, Jessica J., Wong, Pamela T., Morris, Susan, Rasky, Andrew J., Kim, Chang H., Lukacs, Nicholas W., Baker, James R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.07.2024; Elsevier
• Subjects: cell biology; Immunology; Virology; Immunology; cell biology; Virology

Retinoic acid (RA), controls the immunoregulatory functions of many immune cells, including dendritic cells (DCs), and is important for mucosal immunity. In DCs, RA regulates the expression of pattern recognition receptors and stimulates interferon production. Here, we investigated the role of RA in...