Polymorphisms at the PRNP Gene Influence Susceptibility to Chronic Wasting Disease in Two Species of Deer (Odocoileus Spp.) in Western Canada

• Published in: Journal of Toxicology and Environmental Health, Part A Vol. 72; no. 17-18; pp. 1025 - 1029
• Main Authors: Wilson, Gregory A., Nakada, Stephanie M., Bollinger, Trent K., Pybus, Margo J., Merrill, Evelyn H., Coltman, David W.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2009; Taylor & Francis Ltd
• Subjects: Alberta; Alberta - epidemiology; Americas; Amino Acid Sequence; Animals; Base Sequence; Deer; Deer - genetics; Epidemics; Gene expression; Genes; Genetic Predisposition to Disease; Genetics; Genotype; Genotype & phenotype; Heterogeneity; Incidence; Links; Odocoileus; Odocoileus hemionus; Polymorphism; Polymorphism, Genetic; Populations; Prions; Prions - chemistry; Prions - genetics; Proteins; Reproduction; Saskatchewan - epidemiology; Spongiform encephalopathies; Spreads; Wasting Disease, Chronic - epidemiology; Wasting Disease, Chronic - genetics; Alberta; Saskatchewan; Alberta Canada; Saskatchewan Canada; Canada, Saskatchewan; Canada, Alberta

Chronic wasting disease (CWD) is increasingly prevalent in multiple wild mule (Odocoileus hemionus) and white-tailed deer (O. virginianus) herds in North America. CWD was first found in Canadian wild mule deer in Saskatchewan in 2000 and has since spread into the neighboring province of Alberta. The...