Histone Deacetylase Inhibitors Sensitize Human Non-small Cell Lung Cancer Cells to Ionizing Radiation Through Acetyl p53-Mediated c-myc Down-Regulation

• Published in: Journal of thoracic oncology Vol. 6; no. 8; pp. 1313 - 1319
• Main Authors: Seo, Sung-Keum, Jin, Hyeon-Ok, Woo, Sang-Hyeok, Kim, Young-Sun, An, Sungkwan, Lee, Jae-Ho, Hong, Seok-Il, Lee, Kee-Ho, Choe, Tae-Boo, Park, In-Chul
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2011; International Association for the Study of Lung Cancer
• Subjects: Acetylation; Acetylation - drug effects; Acetylation - radiation effects; Apoptosis - drug effects; Apoptosis - radiation effects; Blotting, Western; c-myc; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - therapy; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Proliferation - radiation effects; Combined Modality Therapy; Down-Regulation; Flow Cytometry; HDAC inhibitor; Histone Deacetylase Inhibitors - pharmacology; Humans; Hydroxamic Acids - pharmacology; Ionizing radiation; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Membrane Potential, Mitochondrial - drug effects; Membrane Potential, Mitochondrial - radiation effects; Mutagenesis, Site-Directed; Mutation - genetics; p53; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Radiation, Ionizing; Radiation-Sensitizing Agents - pharmacology; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; HDAC inhibitor; Ionizing radiation; Acetylation; c-myc; p53

Histone deacetylase inhibitors (HDACIs) induce growth arrest and apoptosis in cancer cells. In addition to their intrinsic anticancer properties, HDACIs modulate cellular responses to ionizing radiation (IR). We examined the molecular mechanism(s) associated with the radiosensitizing effects of HDAC...