Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells

• Published in: Stem cells (Dayton, Ohio) Vol. 34; no. 10; pp. 2559 - 2573
• Main Authors: Serena, Carolina, Keiran, Noelia, Ceperuelo‐Mallafre, Victoria, Ejarque, Miriam, Fradera, Rosa, Roche, Kelly, Nuñez‐Roa, Catalina, Vendrell, Joan, Fernández‐Veledo, Sonia
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2016
• Subjects: Adipose tissue; Adipose Tissue - pathology; Adult; Bone marrow; Combined treatment; Diabetes; Diabetes Mellitus, Type 2 - pathology; Female; Human adipose stem cells; Humans; Immune response; Immunosuppression; Inflammasome; Inflammasomes - metabolism; Inflammation; Inflammation - pathology; Interleukin-1beta - metabolism; Invasion; Lymphocytes; Macrophages; Male; Metabolic disorders; Middle Aged; Migration; Obesity; Obesity - pathology; Phagocytosis; Stem cells; Stem Cells - immunology; Stem Cells - metabolism; Tissue Donors; Transforming Growth Factor beta1 - metabolism; Obesity; Immunosuppression; Migration; Inflammasome; Inflammation; Diabetes; Macrophages; Invasion; Phagocytosis; Human adipose stem cells

Adipose tissue‐derived stem cells (ASCs) are proposed as an alternative stem cell source to bone marrow‐derived cells for immune cell therapy. However, microenvironmental factors may impact the functionality of this population in human adipose tissue (AT). We hypothesized that the fat depot in addit...