SIMULTANEOUS ACTION OF THE FLAVONOID QUERCETIN ON CYTOCHROME P450 (CYP) 1A2, CYP2A6, N-ACETYLTRANSFERASE AND XANTHINE OXIDASE ACTIVITY IN HEALTHY VOLUNTEERS

• Published in: Clinical and experimental pharmacology & physiology Vol. 36; no. 8; pp. 828 - 833
• Main Authors: Chen, Yao, Xiao, Peng, Ou-Yang, Dong-Sheng, Fan, Lan, Guo, Dong, Wang, Yi-Nan, Han, Yang, Tu, Jiang-Hua, Zhou, Gan, Huang, Yuan-Fei, Zhou, Hong-Hao
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.08.2009
• Subjects: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases - metabolism; Arylamine N-Acetyltransferase - metabolism; Caffeine - metabolism; Caffeine - pharmacokinetics; Caffeine - urine; Cross-Over Studies; CYP1A2; CYP2A6; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP2A6; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inactivation, Metabolic; Male; N-acetyltransferase; quercetin; Quercetin - administration & dosage; Quercetin - pharmacology; Time Factors; xanthine oxidase; Xanthine Oxidase - metabolism; Young Adult

SUMMARY 1 Quercetin, one of the most abundant natural flavonoids, has been reported to modulate the activity of several drug‐metabolising enzymes. The aim of the present study was to investigate the effects of quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N‐acetyltransferase (NAT2) and xanthine ox...