Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure - Zhou, Bo; Wang, Dennis Ding-Hwa; Qiu, Yanhua; Airhart, Sophia; Liu, Yaxin; Stempien-Otero, April; O’Brien, Kevin D.; Tian, Rong (The Journal of clinical investigation, 2020)
Keywords: Biomedical research; Blood cells; Cardiomyopathy; Care and treatment; Clinical Medicine; Congestive heart failure; Cytokines; Development and progression; Ejection fraction; Electron transport chain; Female; Gene expression; Health aspects; Heart failure; Heart Failure - drug therapy; Heart Failure - metabolism; Heart Failure - pathology; Humans; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Innate immunity; Interleukin 6; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - pathology; Male; Metabolism; Mitochondria; Mitochondria, Heart - metabolism; Mitochondria, Heart - pathology; Mitochondrial DNA; Models, Cardiovascular; NAD; NAD - metabolism; Niacinamide - administration & dosage; Niacinamide - analogs & derivatives; Nicotinamide adenine dinucleotide; Oxygen Consumption - drug effects; Peripheral blood mononuclear cells; Pyridinium Compounds; Respiration; United States; Cardiovascular disease; Mitochondria; Inflammation; Cardiology; Drug therapy