Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality

• Published in: The Journal of clinical investigation Vol. 131; no. 19; pp. 1 - 11
• Main Authors: Snider, Justin M, You, Jeehyun Karen, Wang, Xia, Snider, Ashley J, Hallmark, Brian, Zec, Manja M, Seeds, Michael C, Sergeant, Susan, Johnstone, Laurel, Wang, Qiuming, Sprissler, Ryan, Carr, Tara F, Lutrick, Karen, Parthasarathy, Sairam, Bime, Christian, Zhang, Hao Helen, Luberto, Chiara, Kew, Richard R, Hannun, Yusuf A, Guerra, Stefano, McCall, Charles E, Yao, Guang, Del Poeta, Maurizio, Chilton, Floyd H
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.10.2021
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Atrophy; Bacterial infections; Biomarkers; Biomedical research; Child; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - mortality; Cytochrome; Decision trees; Disease; Disease-Free Survival; Female; Group II Phospholipases A2 - blood; Health aspects; Humans; Hypoxia; Kidney diseases; Kidneys; Learning algorithms; Male; Metabolism; Metabolites; Middle Aged; Mitochondria; Mitochondrial DNA; Molecular modelling; Mortality; Multiple organ dysfunction syndrome; Patients; Phospholipase A2; Phospholipases; Physiological aspects; Plasma; Pneumonia; SARS-CoV-2 - metabolism; Sepsis; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Survival Rate; Therapeutic targets; Urea; United States; COVID-19; Molecular pathology; Inflammation; Cellular immune response

There is an urgent need to identify the cellular and molecular mechanisms responsible for severe COVID-19 that results in death. We initially performed both untargeted and targeted lipidomics as well as focused biochemical analyses of 127 plasma samples and found elevated metabolites associated with...