Massive Transfusion in Cardiac Surgery: The Impact of Blood Component Ratios on Clinical Outcomes and Survival

• Published in: Anesthesia and analgesia Vol. 124; no. 6; pp. 1777 - 1782
• Main Authors: Delaney, Meghan, Stark, Paul C., Suh, Minhyung, Triulzi, Darrell J., Hess, John R., Steiner, Marie E., Stowell, Christopher P., Sloan, Steven R.
• Format: Journal Article
• Language: English
• Published: United States International Anesthesia Research Society 01.06.2017
• Subjects: Aged; Aged, 80 and over; Blood Loss, Surgical - mortality; Blood Loss, Surgical - prevention & control; Cardiac Surgical Procedures - adverse effects; Cardiac Surgical Procedures - mortality; Erythrocyte Transfusion - adverse effects; Erythrocyte Transfusion - mortality; Female; Hospital Mortality; Humans; Kaplan-Meier Estimate; Length of Stay; Linear Models; Male; Middle Aged; Multiple Organ Failure - diagnosis; Multiple Organ Failure - etiology; Multiple Organ Failure - mortality; Organ Dysfunction Scores; Patient Discharge; Platelet Transfusion - adverse effects; Platelet Transfusion - mortality; Proportional Hazards Models; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; United States

BACKGROUND:Cardiac surgery is the most common setting for massive transfusion in medically advanced countries. Studies of massive transfusion after injury suggest that the ratios of administered plasma and platelets (PLT) to red blood cells (RBCs) affect mortality. Data from the Red Cell Storage Dur...