Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

• Published in: Circulation research Vol. 126; no. 4; pp. 439 - 452
• Main Authors: Dikalova, Anna E., Pandey, Arvind, Xiao, Liang, Arslanbaeva, Liaisan, Sidorova, Tatiana, Lopez, Marcos G., Billings, Frederic T., Verdin, Eric, Auwerx, Johan, Harrison, David G., Dikalov, Sergey I.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 14.02.2020
• Subjects: Angiotensin II; Animals; Desoxycorticosterone Acetate; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Essential Hypertension - chemically induced; Essential Hypertension - genetics; Essential Hypertension - metabolism; Female; Heart - physiopathology; Inflammation - genetics; Inflammation - metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitochondria, Heart - genetics; Mitochondria, Heart - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Myocardium - metabolism; Myocardium - pathology; Oxidative Stress; Sirtuin 3 - genetics; Sirtuin 3 - metabolism; acetylation; Sirtuin 3; hypertension; mitochondria; superoxide dismutase; oxidative stress

Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to hypertension, but specific mechanisms are unclear. The mitochondrial deacetylase Sirt3 (Sirtuin 3) is critical in the reg...