Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress - Dikalova, Anna E.; Pandey, Arvind; Xiao, Liang; Arslanbaeva, Liaisan; Sidorova, Tatiana; Lopez, Marcos G.; Billings, Frederic T.; Verdin, Eric; Auwerx, Johan; Harrison, David G.; Dikalov, Sergey I. (Circulation research, 2020)
Keywords: Angiotensin II; Animals; Desoxycorticosterone Acetate; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Essential Hypertension - chemically induced; Essential Hypertension - genetics; Essential Hypertension - metabolism; Female; Heart - physiopathology; Inflammation - genetics; Inflammation - metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitochondria, Heart - genetics; Mitochondria, Heart - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Myocardium - metabolism; Myocardium - pathology; Oxidative Stress; Sirtuin 3 - genetics; Sirtuin 3 - metabolism; acetylation; Sirtuin 3; hypertension; mitochondria; superoxide dismutase; oxidative stress