Hypoxia induces myeloid‐derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C‐C motif) ligand 26

• Published in: Hepatology (Baltimore, Md.) Vol. 64; no. 3; pp. 797 - 813
• Main Authors: Chiu, David Kung‐Chun, Xu, Iris Ming‐Jing, Lai, Robin Kit‐Ho, Tse, Aki Pui‐Wah, Wei, Larry Lai, Koh, Hui‐Yu, Li, Lynna Lan, Lee, Derek, Lo, Regina Cheuk‐Lam, Wong, Chun‐Ming, Ng, Irene Oi‐Lin, Wong, Carmen Chak‐Lui
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.09.2016
• Subjects: Animals; Base Sequence; Carcinoma, Hepatocellular - metabolism; Cell Line, Tumor; Chemokine CCL26; Chemokines; Chemokines, CC - metabolism; CX3C Chemokine Receptor 1; Digoxin; Hepatology; Humans; Hypoxia; Hypoxia - metabolism; Hypoxia-Inducible Factor 1 - metabolism; Ligands; Liver cancer; Liver Neoplasms, Experimental - metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Molecular Sequence Data; Myeloid-Derived Suppressor Cells - physiology; Neovascularization, Pathologic; Receptors, Chemokine - antagonists & inhibitors; Rodents; Tumor Microenvironment

A population of stromal cells, myeloid‐derived suppressor cells (MDSCs), is present in tumors. Though studies have gradually revealed the protumorigenic functions of MDSCs, the molecular mechanisms guiding MDSC recruitment remain largely elusive. Hypoxia, O2 deprivation, is an important factor in th...