Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease

• Published in: Circulation research Vol. 126; no. 5; pp. 663 - 678
• Main Authors: Huang, Cheng-Kai, Kafert-Kasting, Sabine, Thum, Thomas
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 28.02.2020; Lippincott Williams & Wilkins
• Subjects: Animals; Cardiovascular Diseases - therapy; Clinical Trials as Topic; Humans; Reviews; RNAi Therapeutics - methods; Translational Research, Biomedical; animal models; nucleosides; therapeutics; cardiovascular diseases; nucleic acids; nucleotides

RNA modulation has become a promising therapeutic approach for the treatment of several types of disease. The emerging field of noncoding RNA-based therapies has now come to the attention of cardiovascular research, in which it could provide valuable advancements in comparison to current pharmacothe...