Presynaptic D2 Dopamine Receptors Control Long-Term Depression Expression and Memory Processes in the Temporal Hippocampus

• Published in: Biological psychiatry (1969) Vol. 77; no. 6; pp. 513 - 525
• Main Authors: Rocchetti, Jill, Isingrini, Elsa, Dal Bo, Gregory, Sagheby, Sara, Menegaux, Aurore, Tronche, François, Levesque, Daniel, Moquin, Luc, Gratton, Alain, Wong, Tak Pan, Rubinstein, Marcelo, Giros, Bruno
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2015
• Subjects: Animals; Antipsychotics; D2 dopamine receptors; Dopamine D2 Receptor Antagonists - pharmacology; Excitatory Postsynaptic Potentials - drug effects; Excitatory Postsynaptic Potentials - physiology; Hippocampus - drug effects; Hippocampus - physiology; Learning - drug effects; Learning - physiology; Long-Term Potentiation - drug effects; Long-Term Potentiation - physiology; Long-Term Synaptic Depression - drug effects; Long-Term Synaptic Depression - physiology; LTD; Male; Memory; Memory - drug effects; Memory - physiology; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways - drug effects; Neural Pathways - physiology; Neuronal plasticity; Psychiatry; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D2 - metabolism; RNA, Messenger - metabolism; Space Perception - drug effects; Space Perception - physiology; Temporal hippocampus; Ventral Tegmental Area - drug effects; Ventral Tegmental Area - physiology; Antipsychotics; D 2 dopamine receptors; Neuronal plasticity; Temporal hippocampus; LTD; Memory; D2 dopamine receptors; D dopamine receptors

Abstract Background Dysfunctional mesocorticolimbic dopamine signaling has been linked to alterations in motor and reward-based functions associated with psychiatric disorders. Converging evidence from patients with psychiatric disorders and use of antipsychotics suggests that imbalance of dopamine...