In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles

• Published in: Advanced materials (Weinheim) Vol. 25; no. 23; pp. 3144 - 3176
• Main Authors: Chen, Yu, Chen, Hangrong, Shi, Jianlin
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 18.06.2013; WILEY‐VCH Verlag
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Biocompatibility; Biocompatible Materials - chemistry; Biomaterials; Biomedical materials; Contrast Media; diagnosis; Drug Carriers - chemistry; Humans; In vivo; In vivo testing; In vivo tests; Lipid Bilayers - metabolism; mesoporous silica; Nanocomposites; nanomedicine; Nanoparticles - chemistry; Nanostructure; Neoplasms - diagnosis; Neoplasms - diagnostic imaging; Neoplasms - drug therapy; Porosity; RNA, Small Interfering - administration & dosage; Silicon Dioxide - chemistry; Surgical implants; therapy; Tissue Engineering; Ultrasonography

The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material‐based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages...