In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles
The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material‐based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages...
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| Published in | Advanced materials (Weinheim) Vol. 25; no. 23; pp. 3144 - 3176 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
WILEY-VCH Verlag
18.06.2013
WILEY‐VCH Verlag |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0935-9648 1521-4095 1521-4095 |
| DOI | 10.1002/adma.201205292 |
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| Abstract | The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material‐based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages of the engineered inorganic material‐based NPs. Colloidal mesoporous silica NPs (MSNs), one of the most representative and well‐established inorganic materials, have been promoted into biology and medicine, and shifted from extensive in vitro research towards preliminary in vivo assays in small‐animal disease models. In this comprehensive review, the recent progresses in chemical design and engineering of MSNs‐based biomaterials for in vivo biomedical applications has been detailed and overviewed. Due to the intrinsic structural characteristics of elaborately designed MSNs such as large surface area, high pore volume and easy chemical functionalization, they have been extensively investigated for therapeutic, diagnostic and theranostic (concurrent diagnosis and therapy) purposes, especially in oncology. Systematic in vivo bio‐safety evaluations of MSNs have revealed the evidences that the in vivo bio‐behaviors of MSNs are strongly related to their preparation prodecures, particle sizes, geometries, surface chemistries, dosing parameters and even administration routes. In vivo pharmacokinetics and pharmacodynamics further demonstrated the effectiveness of MSNs as the passively and/or actively targeted drug delivery systems (DDSs) for cancer chemotherapy. Especially, the advance of nano‐synthetic chemistry enables the production of composite MSNs for advanced in vivo therapeutic purposes such as gene delivery, stimuli‐responsive drug release, photothermal therapy, photodynamic therapy, ultrasound therapy, or anti‐bacteria in tissue engineering, or as the contrast agents for biological and diagnostic imaging. Additionally, the critical issues and potential challenges related to the chemical design/synthesis of MSNs‐based “magic bullet” by advanced nano‐synthetic chemistry and in vivo evaluation have been discussed to highlight the issues scientists face in promoting the translation of MSNs‐based DDSs into clinical trials.
Significant progress in nano‐biotechnology has promoted the biomedical evaluation and diagnostic/therapeutic applications of mesoporous silica nanoparticles (MSNs) from extensive in vitro research towards preliminary in vivo evaluation. This comprehensive review highlights the recent progresses in the chemical design and engineering of MSN‐based biomaterials for in vivo biomedical applications. |
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| AbstractList | The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material‐based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages of the engineered inorganic material‐based NPs. Colloidal mesoporous silica NPs (MSNs), one of the most representative and well‐established inorganic materials, have been promoted into biology and medicine, and shifted from extensive in vitro research towards preliminary in vivo assays in small‐animal disease models. In this comprehensive review, the recent progresses in chemical design and engineering of MSNs‐based biomaterials for in vivo biomedical applications has been detailed and overviewed. Due to the intrinsic structural characteristics of elaborately designed MSNs such as large surface area, high pore volume and easy chemical functionalization, they have been extensively investigated for therapeutic, diagnostic and theranostic (concurrent diagnosis and therapy) purposes, especially in oncology. Systematic in vivo bio‐safety evaluations of MSNs have revealed the evidences that the in vivo bio‐behaviors of MSNs are strongly related to their preparation prodecures, particle sizes, geometries, surface chemistries, dosing parameters and even administration routes. In vivo pharmacokinetics and pharmacodynamics further demonstrated the effectiveness of MSNs as the passively and/or actively targeted drug delivery systems (DDSs) for cancer chemotherapy. Especially, the advance of nano‐synthetic chemistry enables the production of composite MSNs for advanced in vivo therapeutic purposes such as gene delivery, stimuli‐responsive drug release, photothermal therapy, photodynamic therapy, ultrasound therapy, or anti‐bacteria in tissue engineering, or as the contrast agents for biological and diagnostic imaging. Additionally, the critical issues and potential challenges related to the chemical design/synthesis of MSNs‐based “magic bullet” by advanced nano‐synthetic chemistry and in vivo evaluation have been discussed to highlight the issues scientists face in promoting the translation of MSNs‐based DDSs into clinical trials. The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material-based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages of the engineered inorganic material-based NPs. Colloidal mesoporous silica NPs (MSNs), one of the most representative and well-established inorganic materials, have been promoted into biology and medicine, and shifted from extensive in vitro research towards preliminary in vivo assays in small-animal disease models. In this comprehensive review, the recent progresses in chemical design and engineering of MSNs-based biomaterials for in vivo biomedical applications has been detailed and overviewed. Due to the intrinsic structural characteristics of elaborately designed MSNs such as large surface area, high pore volume and easy chemical functionalization, they have been extensively investigated for therapeutic, diagnostic and theranostic (concurrent diagnosis and therapy) purposes, especially in oncology. Systematic in vivo bio-safety evaluations of MSNs have revealed the evidences that the in vivo bio-behaviors of MSNs are strongly related to their preparation prodecures, particle sizes, geometries, surface chemistries, dosing parameters and even administration routes. In vivo pharmacokinetics and pharmacodynamics further demonstrated the effectiveness of MSNs as the passively and/or actively targeted drug delivery systems (DDSs) for cancer chemotherapy. Especially, the advance of nano-synthetic chemistry enables the production of composite MSNs for advanced in vivo therapeutic purposes such as gene delivery, stimuli-responsive drug release, photothermal therapy, photodynamic therapy, ultrasound therapy, or anti-bacteria in tissue engineering, or as the contrast agents for biological and diagnostic imaging. Additionally, the critical issues and potential challenges related to the chemical design/synthesis of MSNs-based "magic bullet" by advanced nano-synthetic chemistry and in vivo evaluation have been discussed to highlight the issues scientists face in promoting the translation of MSNs-based DDSs into clinical trials.The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material-based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages of the engineered inorganic material-based NPs. Colloidal mesoporous silica NPs (MSNs), one of the most representative and well-established inorganic materials, have been promoted into biology and medicine, and shifted from extensive in vitro research towards preliminary in vivo assays in small-animal disease models. In this comprehensive review, the recent progresses in chemical design and engineering of MSNs-based biomaterials for in vivo biomedical applications has been detailed and overviewed. Due to the intrinsic structural characteristics of elaborately designed MSNs such as large surface area, high pore volume and easy chemical functionalization, they have been extensively investigated for therapeutic, diagnostic and theranostic (concurrent diagnosis and therapy) purposes, especially in oncology. Systematic in vivo bio-safety evaluations of MSNs have revealed the evidences that the in vivo bio-behaviors of MSNs are strongly related to their preparation prodecures, particle sizes, geometries, surface chemistries, dosing parameters and even administration routes. In vivo pharmacokinetics and pharmacodynamics further demonstrated the effectiveness of MSNs as the passively and/or actively targeted drug delivery systems (DDSs) for cancer chemotherapy. Especially, the advance of nano-synthetic chemistry enables the production of composite MSNs for advanced in vivo therapeutic purposes such as gene delivery, stimuli-responsive drug release, photothermal therapy, photodynamic therapy, ultrasound therapy, or anti-bacteria in tissue engineering, or as the contrast agents for biological and diagnostic imaging. Additionally, the critical issues and potential challenges related to the chemical design/synthesis of MSNs-based "magic bullet" by advanced nano-synthetic chemistry and in vivo evaluation have been discussed to highlight the issues scientists face in promoting the translation of MSNs-based DDSs into clinical trials. The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material‐based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages of the engineered inorganic material‐based NPs. Colloidal mesoporous silica NPs (MSNs), one of the most representative and well‐established inorganic materials, have been promoted into biology and medicine, and shifted from extensive in vitro research towards preliminary in vivo assays in small‐animal disease models. In this comprehensive review, the recent progresses in chemical design and engineering of MSNs‐based biomaterials for in vivo biomedical applications has been detailed and overviewed. Due to the intrinsic structural characteristics of elaborately designed MSNs such as large surface area, high pore volume and easy chemical functionalization, they have been extensively investigated for therapeutic, diagnostic and theranostic (concurrent diagnosis and therapy) purposes, especially in oncology. Systematic in vivo bio‐safety evaluations of MSNs have revealed the evidences that the in vivo bio‐behaviors of MSNs are strongly related to their preparation prodecures, particle sizes, geometries, surface chemistries, dosing parameters and even administration routes. In vivo pharmacokinetics and pharmacodynamics further demonstrated the effectiveness of MSNs as the passively and/or actively targeted drug delivery systems (DDSs) for cancer chemotherapy. Especially, the advance of nano‐synthetic chemistry enables the production of composite MSNs for advanced in vivo therapeutic purposes such as gene delivery, stimuli‐responsive drug release, photothermal therapy, photodynamic therapy, ultrasound therapy, or anti‐bacteria in tissue engineering, or as the contrast agents for biological and diagnostic imaging. Additionally, the critical issues and potential challenges related to the chemical design/synthesis of MSNs‐based “magic bullet” by advanced nano‐synthetic chemistry and in vivo evaluation have been discussed to highlight the issues scientists face in promoting the translation of MSNs‐based DDSs into clinical trials. Significant progress in nano‐biotechnology has promoted the biomedical evaluation and diagnostic/therapeutic applications of mesoporous silica nanoparticles (MSNs) from extensive in vitro research towards preliminary in vivo evaluation. This comprehensive review highlights the recent progresses in the chemical design and engineering of MSN‐based biomaterials for in vivo biomedical applications. The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material-based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages of the engineered inorganic material-based NPs. Colloidal mesoporous silica NPs (MSNs), one of the most representative and well-established inorganic materials, have been promoted into biology and medicine, and shifted from extensive in vitro research towards preliminary in vivo assays in small-animal disease models. In this comprehensive review, the recent progresses in chemical design and engineering of MSNs-based biomaterials for in vivo biomedical applications has been detailed and overviewed. Due to the intrinsic structural characteristics of elaborately designed MSNs such as large surface area, high pore volume and easy chemical functionalization, they have been extensively investigated for therapeutic, diagnostic and theranostic (concurrent diagnosis and therapy) purposes, especially in oncology. Systematic in vivo bio-safety evaluations of MSNs have revealed the evidences that the in vivo bio-behaviors of MSNs are strongly related to their preparation prodecures, particle sizes, geometries, surface chemistries, dosing parameters and even administration routes. In vivo pharmacokinetics and pharmacodynamics further demonstrated the effectiveness of MSNs as the passively and/or actively targeted drug delivery systems (DDSs) for cancer chemotherapy. Especially, the advance of nano-synthetic chemistry enables the production of composite MSNs for advanced in vivo therapeutic purposes such as gene delivery, stimuli-responsive drug release, photothermal therapy, photodynamic therapy, ultrasound therapy, or anti-bacteria in tissue engineering, or as the contrast agents for biological and diagnostic imaging. Additionally, the critical issues and potential challenges related to the chemical design/synthesis of MSNs-based "magic bullet" by advanced nano-synthetic chemistry and in vivo evaluation have been discussed to highlight the issues scientists face in promoting the translation of MSNs-based DDSs into clinical trials. Significant progress in nano-biotechnology has promoted the biomedical evaluation and diagnostic/therapeutic applications of mesoporous silica nanoparticles (MSNs) from extensive in vitro research towards preliminary in vivo evaluation. This comprehensive review highlights the recent progresses in the chemical design and engineering of MSN-based biomaterials for in vivo biomedical applications. |
| Author | Shi, Jianlin Chen, Yu Chen, Hangrong |
| Author_xml | – sequence: 1 givenname: Yu surname: Chen fullname: Chen, Yu organization: State Key Laboratory of High Performance, Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, P. R. China – sequence: 2 givenname: Hangrong surname: Chen fullname: Chen, Hangrong email: hrchen@mail.sic.ac.cn organization: State Key Laboratory of High Performance, Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, P. R. China – sequence: 3 givenname: Jianlin surname: Shi fullname: Shi, Jianlin email: jlshi@sunm.shcnc.ac.cn organization: State Key Laboratory of High Performance, Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, P. R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23681931$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.taap.2009.04.010 10.1002/smll.200900923 10.1021/ja028650l 10.1002/adma.201103343 10.1021/cm0705789 10.1038/nnano.2007.387 10.1021/nn2039643 10.1021/ja910846q 10.1021/ja1022267 10.1021/ja809346n 10.1039/b905158a 10.1038/nature01362 10.1016/S1748-0132(07)70084-1 10.1038/nmat2992 10.1016/j.addr.2009.11.007 10.1021/ja051113r 10.1002/smll.201001459 10.1002/anie.200501819 10.1038/nrc1591 10.1002/chem.201102599 10.1016/j.addr.2012.06.006 10.1002/adma.201101586 10.1002/jbm.a.31923 10.1039/c0jm03915b 10.1002/smll.200901789 10.1002/adfm.200701317 10.1002/anie.201106180 10.1021/nn1029229 10.1016/j.biomaterials.2011.12.008 10.1021/ar600032u 10.1021/jp9043978 10.1002/anie.200604488 10.2174/138161208784746671 10.1096/fj.04-2747rev 10.1016/j.biomaterials.2010.11.025 10.1021/cr0300789 10.1021/cr9004007 10.1021/ja211035w 10.1021/nl0502569 10.1016/j.micromeso.2010.01.009 10.1039/b9nr00162j 10.1002/adma.201104797 10.1259/bjr/17150274 10.1038/nrc1566 10.1016/j.micromeso.2009.03.031 10.1002/adfm.201002337 10.1021/nn200306g 10.1016/j.biomaterials.2011.10.017 10.1021/cr900232t 10.1016/j.biomaterials.2009.10.046 10.1016/j.addr.2012.05.008 10.1002/smll.201100521 10.1021/nn700008s 10.1016/j.jconrel.2011.10.037 10.1002/smll.201000538 10.1002/adma.201104714 10.1021/ja001106x 10.1021/jz2013837 10.1021/mp200287c 10.1002/anie.201004133 10.1016/j.addr.2008.08.003 10.1002/adma.201104763 10.1002/adfm.200601191 10.1016/j.biomaterials.2012.02.056 10.1016/j.solidstatesciences.2007.11.026 10.1039/c0cc05520d 10.1039/c1cc11479d 10.1021/nn202399w 10.1016/j.jconrel.2011.05.017 10.1039/c2cs15308d 10.1021/tx300166u 10.1021/cr200355j 10.1021/cr030698 10.2147/IJN.S26547 10.1002/anie.201203993 10.1021/cr000108x 10.1021/nl202949y 10.1039/c0jm00645a 10.1021/nn100918a 10.1016/j.micromeso.2009.11.015 10.1021/nl901589y 10.1021/nn101499d 10.1016/j.nantod.2011.10.003 10.1039/b902685a 10.1021/ja8060886 10.1016/j.addr.2008.03.012 10.1016/j.biomaterials.2012.06.059 10.1259/0007-1285-68-816-1296 10.1002/jbm.a.31371 10.2174/156720111797635522 10.1002/adma.201104033 10.1021/cm702792e 10.1021/ja0777584 10.1002/anie.201103108 10.1016/j.jconrel.2007.12.017 10.1039/c2cs15327k 10.1038/nbt1340 10.1021/ja2010175 10.1021/nl034134x 10.1016/j.micromeso.2005.05.001 10.1002/ejic.201101163 10.1039/c2cs15355f 10.1038/359710a0 10.1039/c1cc11760b 10.1002/anie.200603404 10.1002/smll.201200028 10.1002/adma.200900599 10.1021/ja710193c 10.1021/nn2043803 10.1002/adma.201201742 10.1016/j.addr.2008.08.004 10.1016/j.biomaterials.2010.10.035 10.1039/b822444g 10.1016/S1369-7021(11)70161-4 10.1021/ja057254a 10.1021/cr068445e 10.1021/nn103130q 10.1002/anie.201104765 10.1039/b902985k 10.1016/j.solidstatesciences.2005.04.003 10.1021/ja9061085 10.1016/j.actbio.2011.06.028 10.1016/j.jcis.2011.03.051 10.1002/smll.200902355 10.1021/cr100025t 10.1021/ja905793q 10.1126/science.1104274 10.1021/ja00053a020 10.1021/cm051198v 10.2217/nnm.11.19 10.1021/ja0565875 10.1021/jp306543q 10.1021/nn200809t 10.1148/radiol.2502080498 10.1088/0957-4484/20/4/045602 10.1126/science.279.5350.548 10.1002/cbic.200700509 10.1016/j.biomaterials.2012.02.060 10.1021/cr940351u 10.1016/j.biomaterials.2012.09.029 10.1002/adma.200600387 10.1039/c0md00139b 10.1021/nn200372g 10.1038/nrclinonc.2010.139 10.1002/anie.201002639 10.1021/ar2000259 10.1021/ja1084095 10.1016/j.biomaterials.2009.01.029 10.1007/3-540-45733-X_6 10.1016/S0022-5347(05)64992-0 10.2217/nnm.11.166 10.1016/j.addr.2012.06.012 10.1002/smll.201101055 10.1021/nn202863x 10.1021/nn100690m 10.1021/ar800018v 10.1038/nrd1033 10.1002/smll.200800926 10.1021/cm3001688 10.1016/j.nano.2011.06.002 10.1016/j.micromeso.2005.06.015 10.1016/j.biomaterials.2008.07.007 10.1016/j.addr.2003.07.013 10.1016/j.biomaterials.2010.05.065 10.1002/anie.200501500 10.1002/anie.200900880 10.1002/adfm.200800753 10.1021/cm703363w 10.1093/nar/gkq893 10.1021/cr068020s 10.1039/c1nr10718f 10.1002/anie.201002820 10.1002/anie.200802585 10.1002/smll.200701316 10.1021/ja201779d 10.1021/ja904456d 10.1039/c2nr12094a 10.1039/c0jm04115g 10.1021/nn800072t 10.1039/b517615h 10.1016/j.biomaterials.2009.09.060 10.1021/nn901398j 10.1021/nl0347334 10.1021/ja807798g 10.1021/nl902715v 10.1039/C1JM13102H 10.1021/nn200365a 10.1038/ncpneph0660 10.1039/b402025a 10.1016/j.biomaterials.2012.03.066 10.1002/anie.200602866 10.1038/nbt1006-1211 10.1002/adfm.201001495 10.1039/c0jm03851b 10.1021/ja901831u 10.1002/adfm.201102052 10.1016/S1476-5586(03)80005-2 10.1016/j.addr.2006.09.020 10.1039/c0cc02914a 10.1016/j.biomaterials.2010.07.103 10.1039/c1cs15246g 10.1016/j.biomaterials.2010.04.055 10.1172/JCI45600 10.1016/j.biomaterials.2011.11.086 10.1002/adma.200800854 10.1021/ja900025f 10.1021/ja206998x 10.1039/C1CS15187H 10.1038/nbt994 10.1039/B406727D 10.1021/jp103982a 10.1021/ja0772086 10.1016/j.biomaterials.2012.05.065 10.1002/anie.201001847 10.1002/smll.200900621 10.1021/ar200106e 10.1093/jnci/90.12.889 10.1002/adfm.201100031 10.1002/adfm.200500565 10.1039/C1CS15248C 10.1016/j.jconrel.2012.05.046 10.1021/nn800781r 10.1021/la903008z 10.1038/nnano.2007.108 10.1016/j.biomaterials.2010.01.015 10.1039/b804594a 10.1016/j.nantod.2011.02.007 10.1021/nn1015117 10.1016/j.progsolidstchem.2007.10.002 10.1039/c1cc13658e 10.1021/cm0204371 10.1021/cm203000u 10.1021/cm0011559 10.1002/adma.200901096 10.1002/smll.201001447 10.1016/j.biomaterials.2010.03.048 10.1021/ar800150g 10.1002/anie.200802469 10.1038/nrc1071 10.1038/nmat1390 10.1002/anie.201000827 10.1111/j.2042-7158.2010.01167.x 10.1002/chem.200600226 10.1002/anie.200200546 10.1039/c0jm02863k |
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| References | X. Michalet, F. F. Pinaud, L. A. Bentolila, J. M. Tsay, S. Doose, J. J. Li, G. Sundaresan, A. M. Wu, S. S. Gambhir, S. Weiss, Science 2005, 307, 538. Q. J. He, J. L. Shi, F. Chen, M. Zhu, L. X. Zhang, Biomaterials 2010, 31, 3335. J. Kobler, K. Moller, T. Bein, ACS Nano 2008, 2, 791. H. Meng, M. Xue, T. Xia, Z. X. Ji, D. Y. Tarn, J. I. Zink, A. E. Nel, ACS Nano 2011, 5, 4131. L. M. Pan, Q. J. He, J. N. Liu, Y. Chen, M. Ma, L. L. Zhang, J. L. Shi, J. Am. Chem. Soc. 2012, 134, 5722. H. Jaganathan, B. Godin, Adv. Drug Deliv. Rev. 2012, 64, 1800. M. Vendrell, D. T. Zhai, J. C. Er, Y. T. Chang, Chem. Rev. 2012, 112, 4391. Q. He, M. Ma, C. Wei, J. Shi, Biomaterials 2012, 33, 4392. S. Mura, P. Couvreur, Adv. Drug Deliv. Rev. 2012, 64, 1394. M. Hu, J. Y. Chen, Z. Y. Li, L. Au, G. V. Hartland, X. D. Li, M. Marquez, Y. N. Xia, Chem. Soc. Rev. 2006, 35, 1084. H. Yan, C. Teh, S. Sreejith, L. L. Zhu, A. Kwok, W. Q. Fang, X. Ma, K. T. Nguyen, V. Korzh, Y. L. Zhao, Angew. Chem. Int. Ed. 2012, 51, 8373. M. C. Daniel, D. Astruc, Chem. Rev. 2004, 104, 293. J. Kim, H. S. Kim, N. Lee, T. Kim, H. Kim, T. Yu, I. C. Song, W. K. Moon, T. Hyeon, Angew. Chem. Int. Ed. 2008, 47, 8438. Q. J. He, Z. W. Zhang, F. Gao, Y. P. Li, J. L. Shi, Small 2011, 7, 271. I. Izquierdo-Barba, M. Colilla, M. Vallet-Regi, J. Nanomater. 2008, DOI: 10.1155/2008/106970. B. A. Rzigalinski, J. S. Strobl, Toxicol. Appl. Pharm. 2009, 238, 280. A. Bernardos, L. Mondragon, E. Aznar, M. D. Marcos, R. Martinez-Manez, F. Sancenon, J. Soto, J. M. Barat, E. Perez-Paya, C. Guillem, P. Amoros, ACS Nano 2010, 4, 6353. E. Ruiz-Hernandez, A. Lopez-Noriega, D. Arcos, I. Izquierdo-Barba, O. Terasaki, M. Vallet-Regi, Chem. Mater. 2007, 19, 3455. A. M. Derfus, W. C. W. Chan, S. N. Bhatia, Nano Lett. 2004, 4, 11. J. N. Liu, W. B. Bu, S. J. Zhang, F. Chen, H. Y. Xing, L. M. Pan, L. P. Zhou, W. J. Peng, J. L. Shi, Chem. Eur. J. 2012, 18, 2335. K. Riehemann, S. W. Schneider, T. A. Luger, B. Godin, M. Ferrari, H. Fuchs, Angew. Chem. Int. Ed. 2009, 48, 872. S. M. Moghimi, A. C. Hunter, J. C. Murray, FASEB Journal 2005, 19, 311. J. E. Lee, N. Lee, H. Kim, J. Kim, S. H. Choi, J. H. Kim, T. Kim, I. C. Song, S. P. Park, W. K. Moon, T. Hyeon, J. Am. Chem. Soc. 2010, 132, 552. H. K. Na, M. H. Kim, K. Park, S. R. Ryoo, K. E. Lee, H. Jeon, R. Ryoo, C. Hyeon, D. H. Min, Small 2012, 8, 1752. P. P. Yang, S. L. Gai, J. Lin, Chem. Soc. Rev. 2012, 41, 3679. K. Y. Lee, D. J. Mooney, Chem. Rev. 2001, 101, 1869. R. R. Arvizo, S. Bhattacharyya, R. A. Kudgus, K. Giri, R. Bhattacharya, P. Mukherjee, Chem. Soc. Rev. 2012, 41, 2943. S. A. Li, H. A. Liu, L. Li, N. Q. Luo, R. H. Cao, D. H. Chen, Y. Z. Shao, Appl. Phys. Lett. 2011, 98, DOI: DOI: 10.1155/2008/106970. T. T. Wang, F. Chai, Q. Fu, L. Y. Zhang, H. Y. Liu, L. Li, Y. Liao, Z. M. Su, C. A. Wang, B. Y. Duan, D. X. Ren, J. Mater. Chem. 2011, 21, 5299. M. Ma, H. R. Chen, Y. Chen, X. Wang, F. Chen, X. Z. Cui, J. L. Shi, Biomaterials 2012, 33, 989. E. Ruiz-Hernandez, A. Lopez-Noriega, D. Arcos, M. Vallet-Regi, Solid State Sci. 2008, 10, 421. Y. Chen, C. Chu, Y. C. Zhou, Y. F. Ru, H. R. Chen, F. Chen, Q. J. He, Y. L. Zhang, L. L. Zhang, J. L. Shi, Small 2011, 7, 2935. M. Zhu, H. X. Wang, J. Y. Liu, H. L. He, X. G. Hua, Q. J. He, L. X. Zhang, X. J. Ye, J. L. Shi, Biomaterials 2011, 32, 1986. S. Beg, M. Rizwan, A. M. Sheikh, M. S. Hasnain, K. Anwer, K. Kohli, J. Pharm. Pharm. 2011, 63, 141. F. Sharif, F. Porta, A. H. Meijer, A. Kros, M. K. Richardson, Int. J. Nanomed. 2012, 7, 1875. J. S. Beck, J. C. Vartuli, W. J. Roth, M. E. Leonowicz, C. T. Kresge, K. D. Schmitt, C. T. W. Chu, D. H. Olson, E. W. Sheppard, S. B. McCullen, J. B. Higgins, J. L. Schlenker, J. Am. Chem. Soc. 1992, 114, 10834. C. Y. Lai, B. G. Trewyn, D. M. Jeftinija, K. Jeftinija, S. Xu, S. Jeftinija, V. S. Y. Lin, J. Am. Chem. Soc. 2003, 125, 4451. C. H. Lee, S. H. Cheng, I. P. Huang, J. S. Souris, C. S. Yang, C. Y. Mou, L. W. Lo, Angew. Chem. Int. Ed. 2010, 49, 8214. J. M. Rosenholm, A. Meinander, E. Peuhu, R. Niemi, J. E. Eriksson, C. Sahlgren, M. Linden, ACS Nano 2009, 3, 197. Y. Chen, P. Xu, H. Chen, Y. Li, W. Bu, Z. Shu, Y. Li, J. Zhang, L. Zhang, L. Pan, X. Cui, Z. Hua, J. Wang, L. Zhang, J. Shi, Adv. Mater. 2013, DOI: 10.1002/adma.201204685. J. L. Steinbacher, S. A. Lathrop, K. Cheng, J. M. Hillegass, K. Butnor, R. A. Kauppinen, B. T. Mossman, C. C. Landry, Small 2010, 6, 2678. J. M. Rosenholm, E. Peuhu, L. T. Bate-Eya, J. E. Eriksson, C. Sahlgren, M. Linden, Small 2010, 6, 1234. H. S. Choi, W. Liu, P. Misra, E. Tanaka, J. P. Zimmer, B. I. Ipe, M. G. Bawendi, J. V. Frangioni, Nat. Biotechnol. 2007, 25, 1165. C. R. Patra, R. Bhattacharya, D. Mukhopadhyay, P. Mukherjee, Adv. Drug Deliv. Rev. 2010, 62, 346. J. P. Lai, X. Mu, Y. Y. Xu, X. L. Wu, C. L. Wu, C. Li, J. B. Chen, Y. B. Zhao, Chem. Commun. 2010, 46, 7370. J. V. Jokerst, S. S. Gambhir, Acc. Chem. Res. 2011, 44, 1050. M. Ferrari, Nat. Rev. Cancer 2005, 5, 161. A. Baeza, E. Guisasola, E. Ruiz-Hernandez, M. Vallet-Regi, Chem. Mater. 2012, 24, 517. S. H. Cheng, C. C. Hsieh, N. T. Chen, C. H. Chu, C. M. Huang, P. T. Chou, F. G. Tseng, C. S. Yang, C. Y. Mou, L. W. Lo, Nano Today 2011, 6, 552. S. H. Crayton, A. Tsourkas, ACS Nano 2011, 5, 9592. J. G. Penfield, R. F. Reilly, Nat. Clin. Pract. Nephrol. 2007, 3, 654. K. E. Uhrich, S. M. Cannizzaro, R. S. Langer, K. M. Shakesheff, Chem. Rev. 1999, 99, 3181. V. Cauda, A. Schlossbauer, J. Kecht, A. Zurner, T. Bein, J. Am. Chem. Soc. 2009, 131, 11361. R. K. Jain, T. Stylianopoulos, Nat. Rev. Clin. Oncol. 2010, 7, 653. C. D. H. Alarcon, S. Pennadam, C. Alexander, Chem. Soc. Rev. 2005, 34, 276. M. Vallet-Regi, A. Ramila, R. P. del Real, J. Perez-Pariente, Chem. Mater. 2001, 13, 308. H. X. Wu, S. J. Zhang, J. M. Zhang, G. Liu, J. L. Shi, L. X. Zhang, X. Z. Cui, M. L. Ruan, Q. J. He, W. B. Bu, Adv. Funct. Mater. 2011, 21, 1850. J. Zhou, Z. Liu, F. Y. Li, Chem. Soc. Rev. 2012, 41, 1323. Y. Chen, H. R. Chen, S. J. Zhang, F. Chen, L. X. Zhang, J. M. Zhang, M. Zhu, H. X. Wu, L. M. Guo, J. W. Feng, J. L. Shi, Adv. Funct. Mater. 2011, 21, 270. Y. Z. Zhang, J. C. Wang, X. Y. Bai, T. Y. Jiang, Q. Zhang, S. L. Wang, Mol. Pharm. 2012, 9, 505. D. P. Ferris, Y. L. Zhao, N. M. Khashab, H. A. Khatib, J. F. Stoddart, J. I. Zink, J. Am. Chem. Soc. 2009, 131, 1686. Y. Chen, H. R. Chen, Y. Sun, Y. Y. Zheng, D. P. Zeng, F. Q. Li, S. J. Zhang, X. Wang, K. Zhang, M. Ma, Q. J. He, L. L. Zhang, J. L. Shi, Angew. Chem. Int. Ed. 2011, 50, 12505. M. Liong, J. Lu, M. Kovochich, T. Xia, S. G. Ruehm, A. E. Nel, F. Tamanoi, J. I. Zink, ACS Nano 2008, 2, 889. H. X. Wu, G. Liu, S. J. Zhang, J. L. Shi, L. X. Zhang, Y. Chen, F. Chen, H. R. Chen, J. Mater. Chem. 2011, 21, 3037. S. Mornet, S. Vasseur, F. Grasset, E. Duguet, J. Mater. Chem. 2004, 14, 2161. J. M. Harris, R. B. Chess, Nat. Rev. Drug Discov. 2003, 2, 214. S. Giri, B. G. Trewyn, M. P. Stellmaker, V. S. Y. Lin, Angew. Chem. Int. Ed. 2005, 44, 5038. C. E. Ashley, E. C. Carnes, G. K. Phillips, D. Padilla, P. N. Durfee, P. A. Brown, T. N. Hanna, J. W. Liu, B. Phillips, M. B. Carter, N. J. Carroll, X. M. Jiang, D. R. Dunphy, C. L. Willman, D. N. Petsev, D. G. Evans, A. N. Parikh, B. Chackerian, W. Wharton, D. S. Peabody, C. J. Brinker, Nat. Mater. 2011, 10, 389. Y. F. Zhu, J. L. Shi, H. R. Chen, W. H. Shen, X. P. Dong, Micro. Meso. Mater. 2005, 84, 218. T. Asefa, Z. Tao, Chem. Res. Toxicol. 2012, 25, 2265. J. Perez-Rodriguez, S. Lai, B. D. Ehst, D. M. Fine, D. A. Bluemke, Radiology 2009, 250, 371. H. B. Na, T. Hyeon, J. Mater. Chem. 2009, 19, 6267. C. Coll, L. Mondragon, R. Martinez-Manez, F. Sancenon, M. D. Marcos, J. Soto, P. Amoros, E. Perez-Paya, Angew. Chem. Int. Ed. 2011, 50, 2138. R. I. Nooney, D. Thirunavukkarasu, Y. M. Chen, R. Josephs, A. E. Ostafin, Chem. Mater. 2002, 14, 4721. K. Patel, S. Angelos, W. R. Dichtel, A. Coskun, Y. W. Yang, J. I. Zink, J. F. Stoddart, J. Am. Chem. Soc. 2008, 130, 2382. L. Xing, H. Q. Zheng, Y. Y. Cao, S. A. Che, Adv. Mater. 2012, 24, 6433. L. L. Li, Y. Q. Guan, H. Y. Liu, N. J. Hao, T. L. Liu, X. W. Meng, C. H. Fu, Y. Z. Li, Q. L. Qu, Y. G. Zhang, S. Y. Ji, L. Chen, D. Chen, F. Q. Tang, ACS Nano 2011, 5, 7462. D. Dolmans, D. Fukumura, R. K. Jain, Nat. Rev. Cancer 2003, 3, 380. T. Kim, E. J. Cho, Y. Chae, M. Kim, A. Oh, J. Jin, E. S. Lee, H. Baik, S. Haam, J. S. Suh, Y. M. Huh, K. Lee, Angew. Chem. Int. Ed. 2011, 50, 10589. C. E. Chen, F. Pu, Z. Z. Huang, Z. Liu, J. S. Ren, X. G. Qu, Nucleic Acids Res. 2011, 39, 1638. F. Zhang, G. B. Braun, A. Pallaoro, Y. C. Zhang, Y. F. Shi, D. X. Cui, M. Moskovits, D. Y. Zhao, G. D. Stucky, Nano Lett. 2012, 12, 61. C. C. Huang, C. Y. Tsai, H. S. Sheu, K. Y. Chuang, C. H. Su, U. S. Jeng, F. Y. Cheng, H. Y. Lei, C. S. Yeh, ACS Nano 2011, 5, 3905. D. D. Schwert, J. A. Davies, N. Richardson, Contrast Agents I 2002, 221, 165. J. Lu, Z. X. Li, J. I. Zink, F. Tamanoi, Nanome-Nanotechnol. 2012, 8, 212. H. P. Martinez, Y. Kono, S. L. Blair, S. Sandoval, J. Wang-Rodriguez, R. F. Mattrey, A. C. Kummel, W. C. Trogler, Medchemcomm 2010, 1, 266. E. Torres, F. Mainini, R. Napolitano, F. Fedeli, R. Cavalli, S. Aime, E. Terreno, J. Control. Release 2011, 154, 196. X. W. Lou, L. A. Archer, Z. C. Yang, Adv. Mater. 2008, 20, 3987. M. A. Malvindi, A. Greco, F. Conversano, A. Figuerola, M. Corti, M. Bonora, A. Lascialfari, H. A. Doumari, M. Moscardini, R. Cingolani, G. Gigli, S. Casciaro, T. Pellegrino, A. Ragusa, Adv. Funct. Mater. 2011, 21, 2548. J. L. Vivero-Escoto, Slowing, II, B. G. Trewyn, V. S. Y. Lin, Small 2010, 6, 1952. X. Wang, H. Chen, Y. Chen, M. Ma, K. Zhang, F. Li, Y. Zheng, D. Zeng, Q. Wang, J. Shi, Adv. Mater. 2012, 24, 785. Z. X. Li, J. C. Barnes, A. Bosoy, J. F. Stoddart, J. I. Zink, Chem. Soc. Rev. 2012, 41, 2590. I. I. Slowing, C. W. Wu, J. L. Vivero-Escoto, V. S. Y. Lin, Small 2009, 5, 57. A. Bernardos, E. Aznar, M. D. Marcos, R. Martinez-Manez, F. Sancenon, J. Soto, J. M. Barat, P. Amoros, Angew. Chem. Int. Ed. 2009, 48, 5884. X. Wang, H. R. Chen, Y. Chen, M. Ma, K. Zhang, F. Q. Li, Y. Y. Zheng, D. P. Zeng, Q. Wang, J. L. Shi, Adv. Mater. 2012, 24, 785. J. Kim, J. E. Lee, J. Lee, J. H. Yu, B. 2011; 358 2004; 22 2002; 14 2007; 107 2006; 35 2008; 36 2004; 4 2008; 108 2009; 113 2012; 18 1998; 279 2012; 12 2009; 238 2010; 20 2010; 26 2012; 134 2010; 1 2006; 24 2008; 29 2010; 114 2005; 105 1992; 114 2010; 110 2011; 63 1992; 359 2008; 23 2009; 123 1998; 90 2007; 2 2000; 122 2008; 20 2007; 3 2012; 25 2012; 24 2009; 19 2012; 22 2010; 4 2003; 42 2010; 7 2010; 6 2011; 121 2007; 17 2007; 19 2010; 31 2006; 58 2005; 84 2005; 85 2008; 126 2011; 3 2011; 6 2011; 5 2012; 33 2011; 8 2011; 7 2011; 133 2005; 19 2010; 49 2012; 112 2010; 46 2009; 90A 2004; 56 2005; 127 2005; 5 2008; 47 2005; 4 2005; 7 2008; 41 2012; 116 2005; 17 2008; 130 2012; 41 2012; 161 2012; 163 2001; 101 2008; 9 2011; 10 2011; 98 2011; 14 2008; 4 2008; 2 2009; 48 2010; 62 2011; 154 2012; 51 1995; 68 2002; 221 2003; 2 2003; 3 1999; 99 2005; 307 2011; 21 2003; 5 2011; 23 2003; 125 2001; 13 2006; 128 2008; 60 2012; 64 2007; 25 2005; 34 2004; 104 2008; 84A 2009; 21 2009; 20 2006; 12 2008; 18 2006; 16 2008; 14 2008 2006; 18 2011; 32 2008; 10 2009; 250 2009; 131 2011; 39 2005; 44 2003; 76 2009; 30 2012; 3 2013; 34 2004; 14 2011; 50 2002; 167 2010; 132 2009; 9 2011; 44 2010; 131 2007; 40 2009; 5 2013 2011; 47 2012; 6 2009; 3 2012; 7 2009; 1 2012; 4 2003; 421 2007; 46 2012; 8 2012; 9 e_1_2_7_3_2 e_1_2_7_127_2 e_1_2_7_104_2 e_1_2_7_19_2 e_1_2_7_83_2 e_1_2_7_60_2 e_1_2_7_191_2 e_1_2_7_11_2 e_1_2_7_45_2 e_1_2_7_248_2 e_1_2_7_68_2 e_1_2_7_142_2 e_1_2_7_188_2 e_1_2_7_202_2 e_1_2_7_225_2 e_1_2_7_165_2 e_1_2_7_240_2 e_1_2_7_116_2 e_1_2_7_71_2 e_1_2_7_94_2 e_1_2_7_180_2 e_1_2_7_23_2 e_1_2_7_33_2 e_1_2_7_56_2 e_1_2_7_79_2 e_1_2_7_192_2 e_1_2_7_237_2 e_1_2_7_131_2 e_1_2_7_154_2 e_1_2_7_177_2 e_1_2_7_214_2 e_1_2_7_139_2 e_1_2_7_4_2 e_1_2_7_105_2 e_1_2_7_128_2 e_1_2_7_82_2 e_1_2_7_120_2 e_1_2_7_12_2 e_1_2_7_44_2 e_1_2_7_67_2 e_1_2_7_226_2 e_1_2_7_181_2 e_1_2_7_249_2 e_1_2_7_143_2 e_1_2_7_166_2 e_1_2_7_29_2 e_1_2_7_203_2 e_1_2_7_189_2 e_1_2_7_241_2 e_1_2_7_117_2 e_1_2_7_93_2 e_1_2_7_70_2 e_1_2_7_24_2 e_1_2_7_32_2 e_1_2_7_55_2 e_1_2_7_170_2 e_1_2_7_215_2 e_1_2_7_78_2 e_1_2_7_193_2 e_1_2_7_238_2 e_1_2_7_132_2 e_1_2_7_155_2 e_1_2_7_178_2 e_1_2_7_230_2 e_1_2_7_129_2 e_1_2_7_106_2 e_1_2_7_9_2 e_1_2_7_121_2 e_1_2_7_81_2 e_1_2_7_1_2 e_1_2_7_13_2 e_1_2_7_43_2 e_1_2_7_204_2 e_1_2_7_227_2 e_1_2_7_66_2 e_1_2_7_89_2 e_1_2_7_182_2 e_1_2_7_28_2 e_1_2_7_144_2 e_1_2_7_242_2 e_1_2_7_167_2 e_1_2_7_118_2 e_1_2_7_110_2 e_1_2_7_92_2 e_1_2_7_25_2 e_1_2_7_31_2 e_1_2_7_54_2 e_1_2_7_171_2 e_1_2_7_194_2 e_1_2_7_216_2 e_1_2_7_239_2 e_1_2_7_77_2 e_1_2_7_39_2 e_1_2_7_133_2 e_1_2_7_179_2 e_1_2_7_231_2 e_1_2_7_156_2 e_1_2_7_107_2 e_1_2_7_2_2 e_1_2_7_122_2 e_1_2_7_80_2 e_1_2_7_14_2 e_1_2_7_42_2 e_1_2_7_65_2 e_1_2_7_160_2 e_1_2_7_183_2 e_1_2_7_205_2 e_1_2_7_88_2 e_1_2_7_228_2 e_1_2_7_27_2 e_1_2_7_145_2 e_1_2_7_168_2 e_1_2_7_243_2 e_1_2_7_220_2 e_1_2_7_119_2 e_1_2_7_111_2 e_1_2_7_91_2 e_1_2_7_30_2 e_1_2_7_76_2 e_1_2_7_53_2 e_1_2_7_195_2 e_1_2_7_99_2 e_1_2_7_172_2 e_1_2_7_217_2 e_1_2_7_38_2 e_1_2_7_134_2 e_1_2_7_157_2 e_1_2_7_232_2 e_1_2_7_108_2 e_1_2_7_7_2 e_1_2_7_123_2 e_1_2_7_100_2 e_1_2_7_15_2 e_1_2_7_41_2 e_1_2_7_87_2 e_1_2_7_64_2 e_1_2_7_184_2 e_1_2_7_206_2 e_1_2_7_229_2 e_1_2_7_161_2 e_1_2_7_26_2 e_1_2_7_49_2 e_1_2_7_244_2 e_1_2_7_146_2 e_1_2_7_221_2 e_1_2_7_169_2 e_1_2_7_90_2 e_1_2_7_112_2 e_1_2_7_52_2 e_1_2_7_75_2 e_1_2_7_98_2 e_1_2_7_150_2 e_1_2_7_173_2 e_1_2_7_218_2 e_1_2_7_37_2 e_1_2_7_196_2 e_1_2_7_233_2 e_1_2_7_135_2 e_1_2_7_210_2 e_1_2_7_158_2 e_1_2_7_8_2 e_1_2_7_101_2 e_1_2_7_124_2 e_1_2_7_16_2 e_1_2_7_40_2 e_1_2_7_63_2 e_1_2_7_86_2 e_1_2_7_162_2 e_1_2_7_207_2 e_1_2_7_48_2 e_1_2_7_222_2 e_1_2_7_185_2 e_1_2_7_245_2 e_1_2_7_147_2 e_1_2_7_109_2 e_1_2_7_113_2 e_1_2_7_51_2 e_1_2_7_97_2 e_1_2_7_219_2 e_1_2_7_74_2 e_1_2_7_20_2 e_1_2_7_36_2 e_1_2_7_151_2 e_1_2_7_59_2 e_1_2_7_174_2 e_1_2_7_211_2 e_1_2_7_197_2 e_1_2_7_234_2 e_1_2_7_136_2 e_1_2_7_159_2 e_1_2_7_5_2 e_1_2_7_125_2 e_1_2_7_102_2 e_1_2_7_17_2 e_1_2_7_208_2 e_1_2_7_62_2 e_1_2_7_85_2 e_1_2_7_47_2 e_1_2_7_140_2 e_1_2_7_200_2 e_1_2_7_223_2 e_1_2_7_246_2 e_1_2_7_163_2 e_1_2_7_186_2 e_1_2_7_148_2 e_1_2_7_114_2 e_1_2_7_50_2 e_1_2_7_73_2 e_1_2_7_96_2 e_1_2_7_21_2 e_1_2_7_35_2 e_1_2_7_58_2 Chen Y. 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| References_xml | – reference: Y. Chen, Q. Yin, X. F. Ji, S. J. Zhang, H. R. Chen, Y. Y. Zheng, Y. Sun, H. Y. Qu, Z. Wang, Y. P. Li, X. Wang, K. Zhang, L. L. Zhang, J. L. Shi, Biomaterials 2012, 33, 7126. – reference: K. Riehemann, S. W. Schneider, T. A. Luger, B. Godin, M. Ferrari, H. Fuchs, Angew. Chem. Int. Ed. 2009, 48, 872. – reference: A. Pietroiusti, M. Massimiani, I. Fenoglio, M. Colonna, F. Valentini, G. Palleschi, A. Camaioni, A. Magrini, G. Siracusa, A. Bergamaschi, A. Sgambato, L. Campagnolo, ACS Nano 2011, 5, 4624. – reference: J. K. Hsiao, C. P. Tsai, T. H. Chung, Y. Hung, M. Yao, H. M. Liu, C. Y. Mou, C. S. Yang, Y. C. Chen, D. M. Huang, Small 2008, 4, 1445. – reference: S. H. Wu, Y. Hung, C. Y. Mou, Chem. Commun. 2011, 47, 9972. – reference: J. P. Lai, X. Mu, Y. Y. Xu, X. L. Wu, C. L. Wu, C. Li, J. B. Chen, Y. B. Zhao, Chem. Commun. 2010, 46, 7370. – reference: M. Arruebo, R. Fernandez-Pacheco, M. R. Ibarra, J. Santamaria, Nano Today 2007, 2, 22. – reference: Z. G. Feng, Y. S. Li, D. C. Niu, L. Li, W. R. Zhao, H. R. Chen, J. H. Gao, M. L. Ruan, J. L. Shi, Chem. Commun. 2008, 23, 2629. – reference: V. Salgueirino-Maceira, M. A. Correa-Duarte, M. Spasova, L. M. Liz-Marzan, M. Farle, Adv. Funct. Mater. 2006, 16, 509. – reference: F. Sharif, F. Porta, A. H. Meijer, A. Kros, M. K. Richardson, Int. J. Nanomed. 2012, 7, 1875. – reference: I. Izquierdo-Barba, L. Ruiz-Gonzalez, J. C. Doadrio, J. M. Gonzalez-Calbet, M. Vallet-Regi, Solid State Sci. 2005, 7, 983. – reference: M. Hossain, M. Su, J. Phy. Chem. C 2012, 116, 23047. – reference: I. L. Medintz, H. T. Uyeda, E. R. Goldman, H. Mattoussi, Nat. Mater. 2005, 4, 435-446. – reference: W. R. Zhao, M. D. Lang, Y. S. Li, L. Li, J. L. Shi, J. Mater. Chem. 2009, 19, 2778. – reference: D. Arcos, V. Fal-Miyar, E. Ruiz-Hernandez, M. Garcia-Hernandez, M. L. Ruiz-Gonzalez, J. Gonzalez-Calbet, M. Vallet-Regi, J. Mater. Chem. 2012, 22, 64. – reference: S. Lal, S. E. Clare, N. J. Halas, Acc. Chem. Res. 2008, 41, 1842. – reference: C. R. Hill, G. R. terHaar, Brit. J. Radiol. 1995, 68, 1296. – reference: Y. Chen, P. Xu, H. Chen, Y. Li, W. Bu, Z. Shu, Y. Li, J. Zhang, L. Zhang, L. Pan, X. Cui, Z. Hua, J. Wang, L. Zhang, J. Shi, Adv. Mater. 2013, DOI: 10.1002/adma.201204685. – reference: T. Kim, E. Momin, J. Choi, K. Yuan, H. Zaidi, J. Kim, M. Park, N. Lee, M. T. McMahon, A. Quinones-Hinojosa, J. W. M. Bulte, T. Hyeon, A. A. Gilad, J. Am. Chem. Soc. 2011, 133, 2955. – reference: D. Peer, J. M. Karp, S. Hong, O. C. FaroKhzad, R. Margalit, R. Langer, Nat. Nanotechnol. 2007, 2, 751. – reference: T. L. Liu, L. L. Li, C. H. Fu, H. Y. Liu, D. Chen, F. Q. Tang, Biomaterials 2012, 33, 2399. – reference: Y. Z. Shao, X. M. Tian, W. Y. Hu, Y. Y. Zhang, H. Liu, H. Q. He, Y. Y. Shen, F. K. Xie, L. Li, Biomaterials 2012, 33, 6438. – reference: J. N. Liu, W. B. Bu, S. J. Zhang, F. Chen, H. Y. Xing, L. M. Pan, L. P. Zhou, W. J. Peng, J. L. Shi, Chem. Eur. J. 2012, 18, 2335. – reference: H. A. Meng, M. Liong, T. A. Xia, Z. X. Li, Z. X. Ji, J. I. Zink, A. E. Nel, ACS Nano 2010, 4, 4539. – reference: H. S. Choi, W. Liu, P. Misra, E. Tanaka, J. P. Zimmer, B. I. Ipe, M. G. Bawendi, J. V. Frangioni, Nat. Biotechnol. 2007, 25, 1165. – reference: J. T. Robinson, S. M. Tabakman, Y. Y. Liang, H. L. Wang, H. S. Casalongue, D. Vinh, H. J. Dai, J. Am. Chem. Soc. 2011, 133, 6825. – reference: Q. J. He, J. L. Shi, F. Chen, M. Zhu, L. X. Zhang, Biomaterials 2010, 31, 3335. – reference: K. E. Uhrich, S. M. Cannizzaro, R. S. Langer, K. M. Shakesheff, Chem. Rev. 1999, 99, 3181. – reference: H. Jaganathan, B. Godin, Adv. Drug Deliv. Rev. 2012, 64, 1800. – reference: T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, Q. Peng, J. Natl. Cancer Inst. 1998, 90, 889. – reference: O. Veiseh, C. Sun, J. Gunn, N. Kohler, P. Gabikian, D. Lee, N. Bhattarai, R. Ellenbogen, R. Sze, A. Hallahan, J. Olson, M. Q. Zhang, Nano Lett. 2005, 5, 1003. – reference: C. T. Wu, W. Fan, Y. F. Zhu, M. Gelinsky, J. Chang, G. Cuniberti, V. Albrecht, T. Friis, Y. Xiao, Acta Biomater. 2011, 7, 3563. – reference: J. Kobler, K. Moller, T. Bein, ACS Nano 2008, 2, 791. – reference: Q. J. He, Z. W. Zhang, F. Gao, Y. P. Li, J. L. Shi, Small 2011, 7, 271. – reference: K. M. L. Taylor, J. S. Kim, W. J. Rieter, H. An, W. L. Lin, W. B. Lin, J. Am. Chem. Soc. 2008, 130, 2154. – reference: M. Gary-Bobo, Y. Mir, C. Rouxel, D. Brevet, I. Basile, M. Maynadier, O. Vaillant, O. Mongin, M. Blanchard-Desce, A. Morere, M. Garcia, J. O. Durand, L. Raehm, Angew. Chem. Int. Ed. 2011, 50, 11425. – reference: J. M. Harris, R. B. Chess, Nat. Rev. Drug Discov. 2003, 2, 214. – reference: M. Elsabahy, K. L. Wooley, Chem. Soc. Rev. 2012, 41, 2545. – reference: S. Giri, B. G. Trewyn, M. P. Stellmaker, V. S. Y. Lin, Angew. Chem. Int. Ed. 2005, 44, 5038. – reference: H. Hu, H. Zhou, J. Du, Z. Q. Wang, L. An, H. Yang, F. H. Li, H. X. Wu, S. P. Yang, J. Mater. Chem. 2011, 21, 6576. – reference: I. W. Hamley, Angew. Chem. Int. Ed. 2003, 42, 1692. – reference: J. V. Jokerst, T. Lobovkina, R. N. Zare, S. S. Gambhir, Nanomedicine 2011, 6, 715. – reference: P. L. Lin, R. J. Eckersley, E. A. H. Hall, Adv. Mater. 2009, 21, 3949. – reference: C. T. Kresge, M. E. Leonowicz, W. J. Roth, J. C. Vartuli, J. S. Beck, Nature 1992, 359, 710. – reference: H. B. Na, T. Hyeon, J. Mater. Chem. 2009, 19, 6267. – reference: D. D. Schwert, J. A. Davies, N. Richardson, Contrast Agents I 2002, 221, 165. – reference: H. Meng, M. Xue, T. Xia, Z. X. Ji, D. Y. Tarn, J. I. Zink, A. E. Nel, ACS Nano 2011, 5, 4131. – reference: F. Stallmach, J. Karger, C. Krause, M. Jeschke, U. Oberhagemann, J. Am. Chem. Soc. 2000, 122, 9237. – reference: Y. Chen, H. R. Chen, S. J. Zhang, F. Chen, L. X. Zhang, J. M. Zhang, M. Zhu, H. X. Wu, L. M. Guo, J. W. Feng, J. L. Shi, Adv. Funct. Mater. 2011, 21, 270. – reference: P. Juzenas, W. Chen, Y. P. Sun, M. A. N. Coelho, R. Generalov, N. Generalova, I. L. Christensen, Adv. Drug Deliv. Rev. 2008, 60, 1600. – reference: L. Q. Xiong, T. S. Yang, Y. Yang, C. J. Xu, F. Y. Li, Biomaterials 2010, 31, 7078. – reference: Q. Gao, Y. Xu, D. Wu, Y. H. Sun, X. A. Li, J. Phys. Chem. C 2009, 113, 12753-12758. – reference: J. E. Kennedy, Nat. Rev. Cancer 2005, 5, 321. – reference: S. Ganta, H. Devalapally, A. Shahiwala, M. Amiji, J. Control. Release 2008, 126, 187. – reference: Y. N. Zhao, B. G. Trewyn, Slowing, II, V. S. Y. Lin, J. Am. Chem. Soc. 2009, 131, 8398. – reference: L. M. Pan, Q. J. He, J. N. Liu, Y. Chen, M. Ma, L. L. Zhang, J. L. Shi, J. Am. Chem. Soc. 2012, 134, 5722. – reference: X. Yang, X. Liu, Z. Liu, F. Pu, J. Ren, X. Qu, Adv. Mater. 2012, 24, 2890. – reference: K. Patel, S. Angelos, W. R. Dichtel, A. Coskun, Y. W. Yang, J. I. Zink, J. F. Stoddart, J. Am. Chem. Soc. 2008, 130, 2382. – reference: C. R. Patra, R. Bhattacharya, D. Mukhopadhyay, P. Mukherjee, Adv. Drug Deliv. Rev. 2010, 62, 346. – reference: B. G. Trewyn, Slowing, II, S. Giri, H. T. Chen, V. S. Y. Lin, Acc. Chem. Res. 2007, 40, 846. – reference: C. D. H. Alarcon, S. Pennadam, C. Alexander, Chem. Soc. Rev. 2005, 34, 276. – reference: D. P. Ferris, Y. L. Zhao, N. M. Khashab, H. A. Khatib, J. F. Stoddart, J. I. Zink, J. Am. Chem. Soc. 2009, 131, 1686. – reference: S. M. Moghimi, A. C. Hunter, J. C. Murray, FASEB Journal 2005, 19, 311. – reference: Y. S. Li, J. L. Shi, Z. L. Hua, H. R. Chen, M. L. Ruan, D. S. Yan, Nano Lett. 2003, 3, 609. – reference: J. Lu, Z. X. Li, J. I. Zink, F. Tamanoi, Nanome-Nanotechnol. 2012, 8, 212. – reference: J. Pan, D. Wan, J. L. Gong, Chem. Commun. 2011, 47, 3442. – reference: M. Vallet-Regi, E. Ruiz-Hernandez, Adv. Mater. 2011, 23, 5177. – reference: Y. Chen, C. Chu, Y. C. Zhou, Y. F. Ru, H. R. Chen, F. Chen, Q. J. He, Y. L. Zhang, L. L. Zhang, J. L. Shi, Small 2011, 7, 2935. – reference: K. Glunde, D. Artemov, M. F. Penet, M. A. Jacobs, Z. M. Bhujwalla, Chem. Rev. 2010, 110, 3043. – reference: F. G. Gao, L. L. Li, T. L. Liu, N. J. Hao, H. Y. Liu, L. F. Tan, H. B. Li, X. L. Huang, B. Peng, C. M. Yan, L. Q. Yang, X. L. Wu, D. Chen, F. Q. Tang, Nanoscale 2012, 4, 3365. – reference: J. Lu, M. Liong, Z. X. Li, J. I. Zink, F. Tamanoi, Small 2010, 6, 1794. – reference: D. Y. Zhao, J. L. Feng, Q. S. Huo, N. Melosh, G. H. Fredrickson, B. F. Chmelka, G. D. Stucky, Science 1998, 279, 548. – reference: X. L. Huang, L. L. Li, T. L. Liu, N. J. Hao, H. Y. Liu, D. Chen, F. Q. Tang, ACS Nano 2011, 5, 5390. – reference: Q. J. He, J. L. Shi, M. Zhu, Y. Chen, F. Chen, Micro. Meso. Mater. 2010, 131, 314. – reference: C. Wu, Y. Ramaswamy, Y. F. Zhu, R. Zheng, R. Appleyard, A. Howard, H. Zreiqat, Biomaterials 2009, 30, 2199. – reference: M. Hu, J. Y. Chen, Z. Y. Li, L. Au, G. V. Hartland, X. D. Li, M. Marquez, Y. N. Xia, Chem. Soc. Rev. 2006, 35, 1084. – reference: M. Ma, H. R. Chen, Y. Chen, X. Wang, F. Chen, X. Z. Cui, J. L. Shi, Biomaterials 2012, 33, 989. – reference: Y. Deng, D. Qi, C. Deng, X. Zhang, D. Zhao, J. Am. Chem. Soc. 2008, 130, 28. – reference: H. Yamada, C. Urata, Y. Aoyama, S. Osada, Y. Yamauchi, K. Kuroda, Chem. Mater. 2012, 24, 1462. – reference: E. Climent, A. Bernardos, R. Martinez-Manez, A. Maquieira, M. D. Marcos, N. Pastor-Navarro, R. Puchades, F. Sancenon, J. Soto, P. Amoros, J. Am. Chem. Soc. 2009, 131, 14075. – reference: I. I. Slowing, C. W. Wu, J. L. Vivero-Escoto, V. S. Y. Lin, Small 2009, 5, 57. – reference: M. Vallet-Regi, F. Balas, M. Colilla, M. Manzano, Prog. Solid State Chem. 2008, 36, 163. – reference: C. C. Huang, C. Y. Tsai, H. S. Sheu, K. Y. Chuang, C. H. Su, U. S. Jeng, F. Y. Cheng, H. Y. Lei, C. S. Yeh, ACS Nano 2011, 5, 3905. – reference: N. K. Mal, M. Fujiwara, Y. Tanaka, Nature 2003, 421, 350. – reference: A. H. Lu, E. L. Salabas, F. Schuth, Angew. Chem. Int. Ed. 2007, 46, 1222. – reference: Y. Chen, Y. Gao, H. R. Chen, D. P. Zeng, Y. P. Li, Y. Y. Zheng, F. Q. Li, X. F. Ji, X. Wang, F. Chen, Q. J. He, L. L. Zhang, J. L. Shi, Adv. Funct. Mater. 2012, 22, 1586-1597. – reference: D. K. Chatterjee, L. S. Fong, Y. Zhang, Adv. Drug Deliv. Rev. 2008, 60, 1627. – reference: J. Feng, S. Y. Song, R. P. Deng, W. Q. Fan, H. J. Zhang, Langmuir 2010, 26, 3596. – reference: H. J. Kim, H. Matsuda, H. S. Zhou, I. Honma, Adv. Mater. 2006, 18, 3083. – reference: A. Liberman, H. P. Martinez, C. N. Ta, C. V. Barback, R. F. Mattrey, Y. Kono, S. L. Blair, W. C. Trogler, A. C. Kummel, Z. Wu, Biomaterials 2012, 33, 5124. – reference: A. Bernardos, E. Aznar, M. D. Marcos, R. Martinez-Manez, F. Sancenon, J. Soto, J. M. Barat, P. Amoros, Angew. Chem. Int. Ed. 2009, 48, 5884. – reference: Q. J. He, J. L. Shi, X. Z. Cui, C. Y. Wei, L. X. Zhang, W. Wu, W. B. Bu, H. R. Chen, H. X. Wu, Chem. Commun. 2011, 47, 7947. – reference: M. Vallet-Regi, F. Balas, D. Arcos, Angew. Chem. Int. Ed. 2007, 46, 7548. – reference: M. Ferrari, Nat. Rev. Cancer 2005, 5, 161. – reference: F. Q. Tang, L. L. Li, D. Chen, Adv. Mater. 2012, 24, 1504. – reference: K. Y. Lee, D. J. Mooney, Chem. Rev. 2001, 101, 1869. – reference: Y. F. Zhu, J. L. Shi, H. R. Chen, W. H. Shen, X. P. Dong, Micro. Meso. Mater. 2005, 84, 218. – reference: S. E. Skrabalak, J. Y. Chen, Y. G. Sun, X. M. Lu, L. Au, C. M. Cobley, Y. N. Xia, Acc. Chem. Res. 2008, 41, 1587. – reference: I. Izquierdo-Barba, M. Colilla, M. Vallet-Regi, J. Nanomater. 2008, DOI: 10.1155/2008/106970. – reference: T. Kim, E. J. Cho, Y. Chae, M. Kim, A. Oh, J. Jin, E. S. Lee, H. Baik, S. Haam, J. S. Suh, Y. M. Huh, K. Lee, Angew. Chem. Int. Ed. 2011, 50, 10589. – reference: Y. F. Zhu, S. Kaskel, T. Ikoma, N. Hanagata, Micro. Meso. Mater. 2009, 123, 107. – reference: H. Hu, H. Zhou, J. Liang, L. An, A. T. Dai, X. J. Li, H. Yang, S. P. Yang, H. X. Wu, J. Colloid Interface Sci. 2011, 358, 392. – reference: C. Urata, H. Yamada, R. Wakabayashi, Y. Aoyama, S. Hirosawa, S. Arai, S. Takeoka, Y. Yamauchi, K. Kuroda, J. Am. Chem. Soc. 2011, 133, 8102. – reference: M. Vallet-Regi, Chem. Eur. J. 2006, 12, 5934. – reference: W. R. Zhao, H. R. Chen, Y. S. Li, L. Li, M. D. Lang, J. L. Shi, Adv. Funct. Mater. 2008, 18, 2780. – reference: I. I. Slowing J. L. Vivero-Escoto, C. W. Wu, V. S. Y. Lin, Adv. Drug Deliv. Rev. 2008, 60, 1278. – reference: S. A. Li, H. A. Liu, L. Li, N. Q. Luo, R. H. Cao, D. H. Chen, Y. Z. Shao, Appl. Phys. Lett. 2011, 98, DOI: DOI: 10.1155/2008/106970. – reference: H. Y. Liu, T. L. Liu, X. L. Wu, L. L. Li, L. F. Tan, D. Chen, F. Q. Tang, Adv. Mater. 2012, 24, 755. – reference: F. Qin, Y. C. Zhou, J. L. Shi, Y. L. Zhang, J. Biomed. Mater. Res. Part A 2009, 90A, 333. – reference: J. S. Beck, J. C. Vartuli, W. J. Roth, M. E. Leonowicz, C. T. Kresge, K. D. Schmitt, C. T. W. Chu, D. H. Olson, E. W. Sheppard, S. B. McCullen, J. B. Higgins, J. L. Schlenker, J. Am. Chem. Soc. 1992, 114, 10834. – reference: F. Torney, B. G. Trewyn, V. S. Y. Lin, K. Wang, Nat. Nanotechnol. 2007, 2, 295. – reference: Y. Z. Zhang, J. C. Wang, X. Y. Bai, T. Y. Jiang, Q. Zhang, S. L. Wang, Mol. Pharm. 2012, 9, 505. – reference: N. Lee, T. Hyeon, Chem. Soc. Rev. 2012, 41, 2575. – reference: D. Schmaljohann, Adv. Drug Deliv. Rev. 2006, 58, 1655. – reference: T. L. Liu, L. L. Li, X. Teng, X. L. Huang, H. Y. Liu, D. Chen, J. Ren, J. Q. He, F. Q. Tang, Biomaterials 2011, 32, 1657. – reference: C. Y. Liu, J. Guo, W. L. Yang, J. H. Hu, C. C. Wang, S. K. Fu, J. Mater. Chem. 2009, 19, 4764. – reference: M. C. Daniel, D. Astruc, Chem. Rev. 2004, 104, 293. – reference: S. B. Hartono, W. Y. Gu, F. Kleitz, J. Liu, L. Z. He, A. P. J. Middelberg, C. Z. Yu, G. Q. Lu, S. Z. Qiao, ACS Nano 2012, 6, 2104. – reference: E. Terreno, D. D. Castelli, A. Viale, S. Aime, Chem. Rev. 2010, 110, 3019. – reference: Q. J. He, Z. W. Zhang, Y. Gao, J. L. Shi, Y. P. Li, Small 2009, 5, 2722. – reference: A. Bernardos, L. Mondragon, E. Aznar, M. D. Marcos, R. Martinez-Manez, F. Sancenon, J. Soto, J. M. Barat, E. Perez-Paya, C. Guillem, P. Amoros, ACS Nano 2010, 4, 6353. – reference: T. T. Wang, F. Chai, Q. Fu, L. Y. Zhang, H. Y. Liu, L. Li, Y. Liao, Z. M. Su, C. A. Wang, B. Y. Duan, D. X. Ren, J. Mater. Chem. 2011, 21, 5299. – reference: C. E. Chen, F. Pu, Z. Z. Huang, Z. Liu, J. S. Ren, X. G. Qu, Nucleic Acids Res. 2011, 39, 1638. – reference: M. Benezra, O. Penate-Medina, P. B. Zanzonico, D. Schaer, H. Ow, A. Burns, E. DeStanchina, V. Longo, E. Herz, S. Iyer, J. Wolchok, S. M. Larson, U. Wiesner, M. S. Bradbury, J. Clin. Invest. 2011, 121, 2768. – reference: R. I. Nooney, D. Thirunavukkarasu, Y. M. Chen, R. Josephs, A. E. Ostafin, Chem. Mater. 2002, 14, 4721. – reference: H. X. Wu, G. Liu, S. J. Zhang, J. L. Shi, L. X. Zhang, Y. Chen, F. Chen, H. R. Chen, J. Mater. Chem. 2011, 21, 3037. – reference: U. I. Tromsdorf, O. T. Bruns, S. C. Salmen, U. Beisiegel, H. Weller, Nano Lett. 2009, 9, 4434. – reference: Slowing, II, B. G. Trewyn, S. Giri, V. S. Y. Lin, Adv. Funct. Mater. 2007, 17, 1225. – reference: J. E. Kennedy, G. R. ter Haar, D. Cranston, Brit. J. Radiol. 2003, 76, 590. – reference: E. Torres, F. Mainini, R. Napolitano, F. Fedeli, R. Cavalli, S. Aime, E. Terreno, J. Control. Release 2011, 154, 196. – reference: V. Wagner, A. Dullaart, A. K. Bock, A. Zweck, Nat. Biotechnol. 2006, 24, 1211. – reference: R. K. Jain, T. Stylianopoulos, Nat. Rev. Clin. Oncol. 2010, 7, 653. – reference: T. Yu, K. Greish, L. D. McGill, A. Ray, H. Ghandehari, ACS Nano 2012, 6, 2289-2301. – reference: G. Pasut, F. M. Veronese, J. Control. Release 2012, 161, 461. – reference: W. Rima, L. Sancey, M.-T. Aloy, E. Armandy, G. B. Alcantara, T. Epicier, A. Malchère, L. Joly-Pottuz, P. Mowat, F. Lux, O. Tillement, B. Burdin, A. Rivoire, C. Boulé, I. Anselme-Bertrand, J. Pourchez, M. Cottier, S. Roux, C. Rodriguez-Lafrasse, P. Perriat, Biomaterials 2013, 34, 181. – reference: Q. Yang, S. H. Wang, P. W. Fan, L. F. Wang, Y. Di, K. F. Lin, F. S. Xiao, Chem. Mater. 2005, 17, 5999. – reference: J. M. Rosenholm, E. Peuhu, L. T. Bate-Eya, J. E. Eriksson, C. Sahlgren, M. Linden, Small 2010, 6, 1234. – reference: S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. V. Elst, R. N. Muller, Chem. Rev. 2008, 108, 2064. – reference: S. Mornet, S. Vasseur, F. Grasset, E. Duguet, J. Mater. Chem. 2004, 14, 2161. – reference: C. E. Ashley, E. C. Carnes, G. K. Phillips, D. Padilla, P. N. Durfee, P. A. Brown, T. N. Hanna, J. W. Liu, B. Phillips, M. B. Carter, N. J. Carroll, X. M. Jiang, D. R. Dunphy, C. L. Willman, D. N. Petsev, D. G. Evans, A. N. Parikh, B. Chackerian, W. Wharton, D. S. Peabody, C. J. Brinker, Nat. Mater. 2011, 10, 389. – reference: M. Vendrell, D. T. Zhai, J. C. Er, Y. T. Chang, Chem. Rev. 2012, 112, 4391. – reference: L. L. Li, F. Q. Tang, H. Y. Liu, T. L. Liu, N. J. Hao, D. Chen, X. Teng, J. Q. He, ACS Nano 2010, 4, 6874. – reference: X. H. Gao, Y. Y. Cui, R. M. Levenson, L. W. K. Chung, S. M. Nie, Nat. Biotechnol. 2004, 22, 969. – reference: A. Baeza, E. Guisasola, E. Ruiz-Hernandez, M. Vallet-Regi, Chem. Mater. 2012, 24, 517. – reference: Q. J. He, J. L. Shi, J. Mater. Chem. 2011, 21, 5845. – reference: C. G. Trejo, D. Lozano, M. Manzano, J. C. Doadrio, A. J. Salinas, S. Dapia, E. Gomez-Barrena, M. Vallet-Regi, N. Garcia-Honduvilla, J. Bujan, P. Esbrit, Biomaterials 2010, 31, 8564. – reference: C. P. Tsai, C. Y. Chen, Y. Hung, F. H. Chang, C. Y. Mou, J. Mater. Chem. 2009, 19, 5737. – reference: H. Yan, C. Teh, S. Sreejith, L. L. Zhu, A. Kwok, W. Q. Fang, X. Ma, K. T. Nguyen, V. Korzh, Y. L. Zhao, Angew. Chem. Int. Ed. 2012, 51, 8373. – reference: D. Dolmans, D. Fukumura, R. K. Jain, Nat. Rev. Cancer 2003, 3, 380. – reference: W. R. Zhao, J. L. Gu, L. X. Zhang, H. R. Chen, J. L. Shi, J. Am. Chem. Soc. 2005, 127, 8916. – reference: T. Yu, D. Hubbard, A. Ray, H. Ghandehari, J. Control. Release 2012, 163, 46. – reference: X. H. Huang, I. H. El-Sayed, W. Qian, M. A. El-Sayed, J. Am. Chem. Soc. 2006, 128, 2115. – reference: M. Mahkam, Curr. Drug Deliv. 2011, 8, 607. – reference: S. H. Wu, Y. S. Lin, Y. Hung, Y. H. Chou, Y. H. Hsu, C. Chang, C. Y. Mou, Chembiochem 2008, 9, 53. – reference: J. L. Vivero-Escoto, Slowing, II, B. G. Trewyn, V. S. Y. Lin, Small 2010, 6, 1952. – reference: J. G. Penfield, R. F. Reilly, Nat. Clin. Pract. Nephrol. 2007, 3, 654. – reference: A. J. L. Villaraza, A. Bumb, M. W. Brechbiel, Chem. Rev. 2010, 110, 2921. – reference: C. Park, H. Kim, S. Kim, C. Kim, J. Am. Chem. Soc. 2009, 131, 16614. – reference: H. K. Na, M. H. Kim, K. Park, S. R. Ryoo, K. E. Lee, H. Jeon, R. Ryoo, C. Hyeon, D. H. Min, Small 2012, 8, 1752. – reference: J. Liu, S. Z. Qiao, J. S. Chen, X. W. Lou, X. R. Xing, G. Q. Lu, Chem. Commun. 2011, 47, 12578. – reference: Y. Z. You, K. K. Kalebaila, S. L. Brock, D. Oupicky, Chem. Mater. 2008, 20, 3354. – reference: X. L. Huang, F. Zhang, S. Lee, M. Swierczewska, D. O. Kiesewetter, L. X. Lang, G. F. Zhang, L. Zhu, H. K. Gao, H. S. Choi, G. Niu, X. Y. Chen, Biomaterials 2012, 33, 4370. – reference: M. Mizutani, Y. Yamada, T. Nakamura, K. Yano, Chem. Mater. 2008, 20, 4777. – reference: D. Chen, L. L. Li, F. Q. Tang, S. O. Qi, Adv. Mater. 2009, 21, 3804. – reference: E. Climent, R. Martinez-Manez, F. Sancenon, M. D. Marcos, J. Soto, A. Maquieira, P. Amoros, Angew. Chem. Int. Ed. 2010, 49, 7281. – reference: X. L. Huang, J. Zhuang, X. Teng, L. L. Li, D. Chen, X. Y. Yan, F. Q. Tang, Biomaterials 2010, 31, 6142. – reference: X. Li, J. L. Shi, X. P. Dong, L. X. Zhang, H. Y. Zeng, J. Biomed. Mater. Res. Part A 2008, 84A, 84. – reference: J. V. Jokerst, S. S. Gambhir, Acc. Chem. Res. 2011, 44, 1050. – reference: J. L. Steinbacher, S. A. Lathrop, K. Cheng, J. M. Hillegass, K. Butnor, R. A. Kauppinen, B. T. Mossman, C. C. Landry, Small 2010, 6, 2678. – reference: Y. Chen, H. R. Chen, D. P. Zeng, Y. B. Tian, F. Chen, J. W. Feng, J. L. Shi, ACS Nano 2010, 4, 6001. – reference: M. A. Malvindi, A. Greco, F. Conversano, A. Figuerola, M. Corti, M. Bonora, A. Lascialfari, H. A. Doumari, M. Moscardini, R. Cingolani, G. Gigli, S. Casciaro, T. Pellegrino, A. Ragusa, Adv. Funct. Mater. 2011, 21, 2548. – reference: Q. J. He, J. M. Zhang, J. L. Shi, Z. Y. Zhu, L. X. Zhang, W. B. Bu, L. M. Guo, Y. Chen, Biomaterials 2010, 31, 1085. – reference: H. X. Wu, S. J. Zhang, J. M. Zhang, G. Liu, J. L. Shi, L. X. Zhang, X. Z. Cui, M. L. Ruan, Q. J. He, W. B. Bu, Adv. Funct. Mater. 2011, 21, 1850. – reference: R. R. Arvizo, S. Bhattacharyya, R. A. Kudgus, K. Giri, R. Bhattacharya, P. Mukherjee, Chem. Soc. Rev. 2012, 41, 2943. – reference: Y. Wan, D. Y. Zhao, Chem. Rev. 2007, 107, 2821. – reference: A. Schlossbauer, S. Warncke, P. M. E. Gramlich, J. Kecht, A. Manetto, T. Carell, T. Bein, Angew. Chem. Int. Ed. 2010, 49, 4734. – reference: L. L. Li, Y. Q. Guan, H. Y. Liu, N. J. Hao, T. L. Liu, X. W. Meng, C. H. Fu, Y. Z. Li, Q. L. Qu, Y. G. Zhang, S. Y. Ji, L. Chen, D. Chen, F. Q. Tang, ACS Nano 2011, 5, 7462. – reference: S. H. Cheng, C. H. Lee, M. C. Chen, J. S. Souris, F. G. Tseng, C. S. Yang, C. Y. Mou, C. T. Chen, L. W. Lo, J. Mater. Chem. 2010, 20, 6149. – reference: J. H. Ryu, H. Koo, I.-C. Sun, S. H. Yuk, K. Choi, K. Kim, I. C. Kwon, Adv. Drug Deliv. Rev. 2012, 64, 1447. – reference: S. H. Crayton, A. Tsourkas, ACS Nano 2011, 5, 9592. – reference: N. Singh, A. Karambelkar, L. Gu, K. Lin, J. S. Miller, C. S. Chen, M. J. Sailor, S. N. Bhatia, J. Am. Chem. Soc. 2011, 133, 19582. – reference: J. E. Lee, N. Lee, H. Kim, J. Kim, S. H. Choi, J. H. Kim, T. Kim, I. C. Song, S. P. Park, W. K. Moon, T. Hyeon, J. Am. Chem. Soc. 2010, 132, 552. – reference: Y. F. Zhu, J. L. Shi, W. H. Shen, X. P. Dong, J. W. Feng, M. L. Ruan, Y. S. Li, Angew. Chem. Int. Ed. 2005, 44, 5083. – reference: M. Kueny-Stotz, A. Garofalo, D. Felder-Flesch, Eur. J. Inorg. Chem. 2012, 12, 1987-2005. – reference: T. Asefa, Z. Tao, Chem. Res. Toxicol. 2012, 25, 2265. – reference: E. Ruiz-Hernandez, A. Lopez-Noriega, D. Arcos, I. Izquierdo-Barba, O. Terasaki, M. Vallet-Regi, Chem. Mater. 2007, 19, 3455. – reference: J. T. Sun, C. Y. Hong, C. Y. Pan, J. Phys. Chem. C 2010, 114, 12481. – reference: X. Wang, H. Chen, Y. Chen, M. Ma, K. Zhang, F. Li, Y. Zheng, D. Zeng, Q. Wang, J. Shi, Adv. Mater. 2012, 24, 785. – reference: X. W. Lou, L. A. Archer, Z. C. Yang, Adv. Mater. 2008, 20, 3987. – reference: F. Zhang, G. B. Braun, A. Pallaoro, Y. C. Zhang, Y. F. Shi, D. X. Cui, M. Moskovits, D. Y. Zhao, G. D. Stucky, Nano Lett. 2012, 12, 61. – reference: Z. Zhang, L. Wang, J. Wang, X. Jiang, X. Li, Z. Hu, Y. Ji, X. Wu, C. Chen, Adv. Mater. 2012, 24, 1418. – reference: P. A. Schornack, R. J. Gillies, Neoplasia 2003, 5, 135. – reference: J. M. Rosenholm, E. Peuhu, J. E. Eriksson, C. Sahlgren, M. Linden, Nano Lett. 2009, 9, 3308. – reference: J. M. Rosenholm, A. Meinander, E. Peuhu, R. Niemi, J. E. Eriksson, C. Sahlgren, M. Linden, ACS Nano 2009, 3, 197. – reference: J. S. Souris, C. H. Lee, S. H. Cheng, C. T. Chen, C. S. Yang, J. A. A. Ho, C. Y. Mou, L. W. Lo, Biomaterials 2010, 31, 5564. – reference: Y. S. Lin, C. L. Haynes, J. Am. Chem. Soc. 2010, 132, 4834. – reference: S. P. Rigby, M. Fairhead, C. F. van der Walle, Curr. Pharm. Design 2008, 14, 1821. – reference: H. Y. Liu, D. Chen, L. L. Li, T. L. Liu, L. F. Tan, X. L. Wu, F. Q. Tang, Angew. Chem. Int. Ed. 2011, 50, 891. – reference: S. H. Cheng, C. C. Hsieh, N. T. Chen, C. H. Chu, C. M. Huang, P. T. Chou, F. G. Tseng, C. S. Yang, C. Y. Mou, L. W. Lo, Nano Today 2011, 6, 552. – reference: Y. F. Zhu, J. L. Shi, Y. S. Li, H. R. Chen, W. H. Shen, X. P. Dong, Micro. Meso. Mater. 2005, 85, 75. – reference: K. K. Coti, M. E. Belowich, M. Liong, M. W. Ambrogio, Y. A. Lau, H. A. Khatib, J. I. Zink, N. M. Khashab, J. F. Stoddart, Nanoscale 2009, 1, 16. – reference: A. M. Derfus, W. C. W. Chan, S. N. Bhatia, Nano Lett. 2004, 4, 11. – reference: C. F. van Nostrum, Adv. Drug Deliv. Rev. 2004, 56, 9. – reference: J. L. Vivero-Escoto, Slowing, II, C. W. Wu, V. S. Y. Lin, J. Am. Chem. Soc. 2009, 131, 3462. – reference: X. Wang, H. R. Chen, Y. Chen, M. Ma, K. Zhang, F. Q. Li, Y. Y. Zheng, D. P. Zeng, Q. Wang, J. L. Shi, Adv. Mater. 2012, 24, 785. – reference: S. Mura, P. Couvreur, Adv. Drug Deliv. Rev. 2012, 64, 1394. – reference: Y. Chen, H. R. Chen, L. M. Guo, Q. J. He, F. Chen, J. Zhou, J. W. Feng, J. L. Shi, ACS Nano 2010, 4, 529. – reference: Y. S. Lin, K. R. Hurley, C. L. Haynes, J. Phy. Chem. Lett. 2012, 3, 364. – reference: L. Xing, H. Q. Zheng, Y. Y. Cao, S. A. Che, Adv. Mater. 2012, 24, 6433. – reference: S. P. Hudson, R. F. Padera, R. Langer, D. S. Kohane, Biomaterials 2008, 29, 4045. – reference: H. P. Martinez, Y. Kono, S. L. Blair, S. Sandoval, J. Wang-Rodriguez, R. F. Mattrey, A. C. Kummel, W. C. Trogler, Medchemcomm 2010, 1, 266. – reference: M. Zhu, H. X. Wang, J. Y. Liu, H. L. He, X. G. Hua, Q. J. He, L. X. Zhang, X. J. Ye, J. L. Shi, Biomaterials 2011, 32, 1986. – reference: X. Michalet, F. F. Pinaud, L. A. Bentolila, J. M. Tsay, S. Doose, J. J. Li, G. Sundaresan, A. M. Wu, S. S. Gambhir, S. Weiss, Science 2005, 307, 538. – reference: C. Park, K. Oh, S. C. Lee, C. Kim, Angew. Chem. Int. Ed. 2007, 46, 1455. – reference: Z. Liu, J. T. Robinson, S. M. Tabakman, K. Yang, H. J. Dai, Mater. Today 2011, 14, 316. – reference: Z. X. Li, J. C. Barnes, A. Bosoy, J. F. Stoddart, J. I. Zink, Chem. Soc. Rev. 2012, 41, 2590. – reference: C. Y. Lai, B. G. Trewyn, D. M. Jeftinija, K. Jeftinija, S. Xu, S. Jeftinija, V. S. Y. Lin, J. Am. Chem. Soc. 2003, 125, 4451. – reference: Q. He, M. Ma, C. Wei, J. Shi, Biomaterials 2012, 33, 4392. – reference: M. Vallet-Regi, A. Ramila, R. P. del Real, J. Perez-Pariente, Chem. Mater. 2001, 13, 308. – reference: H. Koo, M. S. Huh, J. H. Ryu, D. E. Lee, I. C. Sun, K. Choi, K. Kim, I. C. Kwon, Nano Today 2011, 6, 204. – reference: H. F. Bao, J. P. Yang, Y. Huang, Z. P. Xu, N. Hao, Z. X. Wu, G. Q. Lu, D. Y. Zhao, Nanoscale 2011, 3, 4069. – reference: J. Zhou, Z. Liu, F. Y. Li, Chem. Soc. Rev. 2012, 41, 1323. – reference: J. C. Love, L. A. Estroff, J. K. Kriebel, R. G. Nuzzo, G. M. Whitesides, Chem. Rev. 2005, 105, 1103. – reference: C. H. Lee, S. H. Cheng, I. P. Huang, J. S. Souris, C. S. Yang, C. Y. Mou, L. W. Lo, Angew. Chem. Int. Ed. 2010, 49, 8214. – reference: Y. Chen, H. R. Chen, Y. Sun, Y. Y. Zheng, D. P. Zeng, F. Q. Li, S. J. Zhang, X. Wang, K. Zhang, M. Ma, Q. J. He, L. L. Zhang, J. L. Shi, Angew. Chem. Int. Ed. 2011, 50, 12505. – reference: P. P. Yang, S. L. Gai, J. Lin, Chem. Soc. Rev. 2012, 41, 3679. – reference: E. Ruiz-Hernandez, A. Baeza, M. Vallet-Regi, ACS Nano 2011, 5, 1259. – reference: S. Beg, M. Rizwan, A. M. Sheikh, M. S. Hasnain, K. Anwer, K. Kohli, J. Pharm. Pharm. 2011, 63, 141. – reference: J. Kim, H. S. Kim, N. Lee, T. Kim, H. Kim, T. Yu, I. C. Song, W. K. Moon, T. Hyeon, Angew. Chem. Int. Ed. 2008, 47, 8438. – reference: Y. Chen, H. Chen, S. Zhang, F. Chen, S. Sun, Q. He, M. Ma, X. Wang, H. Wu, L. Zhang, L. Zhang, J. Shi, Biomaterials 2012, 33, 2388. – reference: X. L. Huang, X. Teng, D. Chen, F. Q. Tang, J. Q. He, Biomaterials 2010, 31, 438. – reference: R. Liu, X. Zhao, T. Wu, P. Y. Feng, J. Am. Chem. Soc. 2008, 130, 14418. – reference: M. Liong, J. Lu, M. Kovochich, T. Xia, S. G. Ruehm, A. E. Nel, F. Tamanoi, J. I. Zink, ACS Nano 2008, 2, 889. – reference: B. A. Rzigalinski, J. S. Strobl, Toxicol. Appl. Pharm. 2009, 238, 280. – reference: V. Cauda, A. Schlossbauer, T. Bein, Micro. Meso. Mater. 2010, 132, 60. – reference: K. U. Kohrmann, M. S. Michel, J. Gaa, E. Marlinghaus, P. Alken, J. Urol. 2002, 167, 2397. – reference: J. M. Rosenholm, V. Mamaeva, C. Sahlgren, M. Linden, Nanomedicine 2012, 7, 111. – reference: C. H. Lee, S. H. Cheng, Y. J. Wang, Y. C. Chen, N. T. Chen, J. Souris, C. T. Chen, C. Y. Mou, C. S. Yang, L. W. Lo, Adv. Funct. Mater. 2009, 19, 215. – reference: M. J. Masarudin, K. Yusoff, R. A. Rahim, M. Z. Hussein, Nanotechnology 2009, 20, DOI: 10.1088/0957-4484/20/4/045602. – reference: J. E. Lee, N. Lee, T. Kim, J. Kim, T. Hyeon, Acc. Chem. Res. 2011, 44, 893. – reference: J. Perez-Rodriguez, S. Lai, B. D. Ehst, D. M. Fine, D. A. Bluemke, Radiology 2009, 250, 371. – reference: C. R. Thomas, D. P. Ferris, J. H. Lee, E. Choi, M. H. Cho, E. S. Kim, J. F. Stoddart, J. S. Shin, J. Cheon, J. I. Zink, J. Am. Chem. Soc. 2010, 132, 10623. – reference: J. L. Vivero-Escoto, K. M. L. Taylor-Pashow, R. C. Huxford, J. Della Rocca, C. Okoruwa, H. Y. An, W. L. Lin, W. B. Lin, Small 2011, 7, 3519. – reference: C. Coll, L. Mondragon, R. Martinez-Manez, F. Sancenon, M. D. Marcos, J. Soto, P. Amoros, E. Perez-Paya, Angew. Chem. Int. Ed. 2011, 50, 2138. – reference: J. Kim, J. E. Lee, J. Lee, J. H. Yu, B. C. Kim, K. An, Y. Hwang, C. H. Shin, J. G. Park, T. Hyeon, J. Am. Chem. Soc. 2006, 128, 688. – reference: A. M. Chen, M. Zhang, D. G. Wei, D. Stueber, O. Taratula, T. Minko, H. X. He, Small 2009, 5, 2673. – reference: M. H. Kim, H. K. Na, Y. K. Kim, S. R. Ryoo, H. S. Cho, K. E. Lee, H. Jeon, R. Ryoo, D. H. Min, ACS Nano 2011, 5, 3568. – reference: E. Ruiz-Hernandez, A. Lopez-Noriega, D. Arcos, M. Vallet-Regi, Solid State Sci. 2008, 10, 421. – reference: V. Cauda, A. Schlossbauer, J. Kecht, A. Zurner, T. Bein, J. Am. Chem. Soc. 2009, 131, 11361. – volume: 46 start-page: 7548 year: 2007 publication-title: Angew. Chem. Int. Ed. – volume: 110 start-page: 3043 year: 2010 publication-title: Chem. Rev. – volume: 46 start-page: 1222 year: 2007 publication-title: Angew. Chem. Int. Ed. – volume: 8 start-page: 212 year: 2012 publication-title: Nanome‐Nanotechnol. – volume: 84A start-page: 84 year: 2008 publication-title: J. Biomed. Mater. Res. Part A – volume: 112 start-page: 4391 year: 2012 publication-title: Chem. Rev. – volume: 23 start-page: 5177 year: 2011 publication-title: Adv. Mater. – volume: 17 start-page: 1225 year: 2007 publication-title: Adv. Funct. Mater. – volume: 2 start-page: 22 year: 2007 publication-title: Nano Today – volume: 9 start-page: 505 year: 2012 publication-title: Mol. Pharm. – volume: 132 start-page: 552 year: 2010 publication-title: J. Am. Chem. Soc. – volume: 121 start-page: 2768 year: 2011 publication-title: J. Clin. Invest. – volume: 24 start-page: 2890 year: 2012 publication-title: Adv. Mater. – volume: 29 start-page: 4045 year: 2008 publication-title: Biomaterials – volume: 20 start-page: 3987 year: 2008 publication-title: Adv. Mater. – volume: 64 start-page: 1447 year: 2012 publication-title: Adv. Drug Deliv. Rev. – volume: 128 start-page: 2115 year: 2006 publication-title: J. Am. Chem. Soc. – volume: 7 start-page: 271 year: 2011 publication-title: Small – volume: 167 start-page: 2397 year: 2002 publication-title: J. Urol. – volume: 110 start-page: 3019 year: 2010 publication-title: Chem. Rev. – year: 2013 publication-title: Adv. Mater. – volume: 12 start-page: 5934 year: 2006 publication-title: Chem. Eur. J. – volume: 48 start-page: 5884 year: 2009 publication-title: Angew. Chem. Int. Ed. – volume: 41 start-page: 1587 year: 2008 publication-title: Acc. Chem. Res. – volume: 46 start-page: 7370 year: 2010 publication-title: Chem. Commun. – volume: 1 start-page: 16 year: 2009 publication-title: Nanoscale – volume: 10 start-page: 421 year: 2008 publication-title: Solid State Sci. – volume: 307 start-page: 538 year: 2005 publication-title: Science – volume: 132 start-page: 10623 year: 2010 publication-title: J. Am. Chem. Soc. – volume: 4 start-page: 3365 year: 2012 publication-title: Nanoscale – volume: 131 start-page: 16614 year: 2009 publication-title: J. Am. Chem. Soc. – volume: 21 start-page: 5845 year: 2011 publication-title: J. Mater. Chem. – volume: 110 start-page: 2921 year: 2010 publication-title: Chem. Rev. – volume: 12 start-page: 1987 year: 2012 end-page: 2005 publication-title: Eur. J. Inorg. Chem. – volume: 24 start-page: 1462 year: 2012 publication-title: Chem. Mater. – volume: 3 start-page: 654 year: 2007 publication-title: Nat. Clin. Pract. Nephrol. – volume: 107 start-page: 2821 year: 2007 publication-title: Chem. Rev. – volume: 7 start-page: 983 year: 2005 publication-title: Solid State Sci. – volume: 5 start-page: 135 year: 2003 publication-title: Neoplasia – volume: 21 start-page: 270 year: 2011 publication-title: Adv. Funct. Mater. – volume: 41 start-page: 3679 year: 2012 publication-title: Chem. Soc. Rev. – volume: 7 start-page: 3519 year: 2011 publication-title: Small – volume: 44 start-page: 5038 year: 2005 publication-title: Angew. Chem. Int. Ed. – volume: 48 start-page: 872 year: 2009 publication-title: Angew. Chem. Int. Ed. – volume: 50 start-page: 12505 year: 2011 publication-title: Angew. Chem. Int. Ed. – volume: 7 start-page: 111 year: 2012 publication-title: Nanomedicine – year: 2008 publication-title: J. Nanomater. – volume: 131 start-page: 314 year: 2010 publication-title: Micro. Meso. Mater. – volume: 125 start-page: 4451 year: 2003 publication-title: J. Am. Chem. Soc. – volume: 128 start-page: 688 year: 2006 publication-title: J. Am. Chem. Soc. – volume: 18 start-page: 2780 year: 2008 publication-title: Adv. Funct. Mater. – volume: 20 start-page: 3354 year: 2008 publication-title: Chem. Mater. – volume: 131 start-page: 11361 year: 2009 publication-title: J. Am. Chem. Soc. – volume: 6 start-page: 715 year: 2011 publication-title: Nanomedicine – volume: 41 start-page: 2943 year: 2012 publication-title: Chem. Soc. Rev. – volume: 221 start-page: 165 year: 2002 publication-title: Contrast Agents I – volume: 21 start-page: 1850 year: 2011 publication-title: Adv. Funct. Mater. – volume: 19 start-page: 215 year: 2009 publication-title: Adv. Funct. Mater. – volume: 114 start-page: 12481 year: 2010 publication-title: J. Phys. Chem. C – volume: 18 start-page: 2335 year: 2012 publication-title: Chem. Eur. J. – volume: 154 start-page: 196 year: 2011 publication-title: J. Control. Release – volume: 50 start-page: 2138 year: 2011 publication-title: Angew. Chem. Int. Ed. – volume: 99 start-page: 3181 year: 1999 publication-title: Chem. Rev. – volume: 31 start-page: 438 year: 2010 publication-title: Biomaterials – volume: 8 start-page: 1752 year: 2012 publication-title: Small – volume: 132 start-page: 60 year: 2010 publication-title: Micro. Meso. Mater. – volume: 21 start-page: 6576 year: 2011 publication-title: J. Mater. Chem. – volume: 25 start-page: 2265 year: 2012 publication-title: Chem. Res. Toxicol. – volume: 40 start-page: 846 year: 2007 publication-title: Acc. Chem. Res. – volume: 130 start-page: 2154 year: 2008 publication-title: J. Am. Chem. Soc. – volume: 19 start-page: 5737 year: 2009 publication-title: J. Mater. Chem. – volume: 7 start-page: 2935 year: 2011 publication-title: Small – volume: 7 start-page: 1875 year: 2012 publication-title: Int. J. Nanomed. – volume: 104 start-page: 293 year: 2004 publication-title: Chem. Rev. – volume: 32 start-page: 1986 year: 2011 publication-title: Biomaterials – volume: 22 start-page: 969 year: 2004 publication-title: Nat. Biotechnol. – volume: 9 start-page: 53 year: 2008 publication-title: Chembiochem – volume: 58 start-page: 1655 year: 2006 publication-title: Adv. Drug Deliv. Rev. – volume: 24 start-page: 755 year: 2012 publication-title: Adv. Mater. – volume: 14 start-page: 316 year: 2011 publication-title: Mater. Today – volume: 14 start-page: 2161 year: 2004 publication-title: J. Mater. Chem. – volume: 101 start-page: 1869 year: 2001 publication-title: Chem. Rev. – volume: 132 start-page: 4834 year: 2010 publication-title: J. Am. Chem. Soc. – volume: 5 start-page: 1259 year: 2011 publication-title: ACS Nano – volume: 5 start-page: 2673 year: 2009 publication-title: Small – volume: 131 start-page: 3462 year: 2009 publication-title: J. Am. Chem. Soc. – volume: 5 start-page: 5390 year: 2011 publication-title: ACS Nano – volume: 5 start-page: 9592 year: 2011 publication-title: ACS Nano – volume: 76 start-page: 590 year: 2003 publication-title: Brit. J. Radiol. – volume: 16 start-page: 509 year: 2006 publication-title: Adv. Funct. Mater. – volume: 3 start-page: 197 year: 2009 publication-title: ACS Nano – volume: 36 start-page: 163 year: 2008 publication-title: Prog. Solid State Chem. – volume: 14 start-page: 4721 year: 2002 publication-title: Chem. Mater. – volume: 19 start-page: 3455 year: 2007 publication-title: Chem. Mater. – volume: 134 start-page: 5722 year: 2012 publication-title: J. Am. Chem. Soc. – volume: 19 start-page: 2778 year: 2009 publication-title: J. Mater. Chem. – volume: 30 start-page: 2199 year: 2009 publication-title: Biomaterials – volume: 20 start-page: 6149 year: 2010 publication-title: J. Mater. Chem. – volume: 2 start-page: 214 year: 2003 publication-title: Nat. Rev. Drug Discov. – volume: 39 start-page: 1638 year: 2011 publication-title: Nucleic Acids Res. – volume: 3 start-page: 380 year: 2003 publication-title: Nat. Rev. Cancer – volume: 133 start-page: 8102 year: 2011 publication-title: J. Am. Chem. Soc. – volume: 8 start-page: 607 year: 2011 publication-title: Curr. Drug Deliv. – volume: 13 start-page: 308 year: 2001 publication-title: Chem. Mater. – volume: 5 start-page: 4131 year: 2011 publication-title: ACS Nano – volume: 4 start-page: 1445 year: 2008 publication-title: Small – volume: 19 start-page: 311 year: 2005 publication-title: FASEB Journal – volume: 131 start-page: 14075 year: 2009 publication-title: J. Am. Chem. Soc. – volume: 33 start-page: 6438 year: 2012 publication-title: Biomaterials – volume: 44 start-page: 1050 year: 2011 publication-title: Acc. Chem. Res. – volume: 33 start-page: 5124 year: 2012 publication-title: Biomaterials – volume: 84 start-page: 218 year: 2005 publication-title: Micro. Meso. Mater. – volume: 50 start-page: 11425 year: 2011 publication-title: Angew. Chem. Int. Ed. – volume: 5 start-page: 1003 year: 2005 publication-title: Nano Lett. – volume: 4 start-page: 435 year: 2005 end-page: 446 publication-title: Nat. Mater. – volume: 98 year: 2011 publication-title: Appl. Phys. Lett. – volume: 20 year: 2009 publication-title: Nanotechnology – volume: 90 start-page: 889 year: 1998 publication-title: J. Natl. Cancer Inst. – volume: 21 start-page: 2548 year: 2011 publication-title: Adv. Funct. Mater. – volume: 4 start-page: 6001 year: 2010 publication-title: ACS Nano – volume: 6 start-page: 204 year: 2011 publication-title: Nano Today – volume: 6 start-page: 552 year: 2011 publication-title: Nano Today – volume: 31 start-page: 3335 year: 2010 publication-title: Biomaterials – volume: 123 start-page: 107 year: 2009 publication-title: Micro. Meso. Mater. – volume: 49 start-page: 8214 year: 2010 publication-title: Angew. Chem. Int. Ed. – volume: 31 start-page: 1085 year: 2010 publication-title: Biomaterials – volume: 21 start-page: 3037 year: 2011 publication-title: J. Mater. Chem. – volume: 21 start-page: 5299 year: 2011 publication-title: J. Mater. Chem. – volume: 33 start-page: 4392 year: 2012 publication-title: Biomaterials – volume: 68 start-page: 1296 year: 1995 publication-title: Brit. J. Radiol. – volume: 56 start-page: 9 year: 2004 publication-title: Adv. Drug Deliv. Rev. – volume: 5 start-page: 2722 year: 2009 publication-title: Small – volume: 421 start-page: 350 year: 2003 publication-title: Nature – volume: 105 start-page: 1103 year: 2005 publication-title: Chem. Rev. – volume: 49 start-page: 4734 year: 2010 publication-title: Angew. Chem. Int. Ed. – volume: 5 start-page: 3568 year: 2011 publication-title: ACS Nano – volume: 5 start-page: 4624 year: 2011 publication-title: ACS Nano – volume: 12 start-page: 61 year: 2012 publication-title: Nano Lett. – volume: 10 start-page: 389 year: 2011 publication-title: Nat. Mater. – volume: 25 start-page: 1165 year: 2007 publication-title: Nat. Biotechnol. – volume: 44 start-page: 893 year: 2011 publication-title: Acc. Chem. Res. – volume: 21 start-page: 3804 year: 2009 publication-title: Adv. Mater. – volume: 44 start-page: 5083 year: 2005 publication-title: Angew. Chem. Int. Ed. – volume: 64 start-page: 1394 year: 2012 publication-title: Adv. Drug Deliv. Rev. – volume: 24 start-page: 785 year: 2012 publication-title: Adv. Mater. – volume: 85 start-page: 75 year: 2005 publication-title: Micro. Meso. Mater. – volume: 51 start-page: 8373 year: 2012 publication-title: Angew. Chem. Int. Ed. – volume: 131 start-page: 1686 year: 2009 publication-title: J. Am. Chem. Soc. – volume: 122 start-page: 9237 year: 2000 publication-title: J. Am. Chem. Soc. – volume: 41 start-page: 1323 year: 2012 publication-title: Chem. Soc. Rev. – volume: 50 start-page: 891 year: 2011 publication-title: Angew. Chem. Int. Ed. – volume: 5 start-page: 321 year: 2005 publication-title: Nat. Rev. Cancer – volume: 9 start-page: 4434 year: 2009 publication-title: Nano Lett. – volume: 6 start-page: 2289 year: 2012 end-page: 2301 publication-title: ACS Nano – volume: 5 start-page: 57 year: 2009 publication-title: Small – volume: 5 start-page: 3905 year: 2011 publication-title: ACS Nano – volume: 131 start-page: 8398 year: 2009 publication-title: J. Am. Chem. Soc. – volume: 7 start-page: 653 year: 2010 publication-title: Nat. Rev. Clin. Oncol. – volume: 41 start-page: 2575 year: 2012 publication-title: Chem. Soc. Rev. – volume: 90A start-page: 333 year: 2009 publication-title: J. Biomed. Mater. Res. Part A – volume: 31 start-page: 8564 year: 2010 publication-title: Biomaterials – volume: 31 start-page: 6142 year: 2010 publication-title: Biomaterials – volume: 24 start-page: 1211 year: 2006 publication-title: Nat. Biotechnol. – volume: 60 start-page: 1278 year: 2008 publication-title: Adv. Drug Deliv. Rev. – volume: 47 start-page: 8438 year: 2008 publication-title: Angew. Chem. Int. Ed. – volume: 6 start-page: 1234 year: 2010 publication-title: Small – volume: 41 start-page: 1842 year: 2008 publication-title: Acc. Chem. Res. – volume: 4 start-page: 529 year: 2010 publication-title: ACS Nano – volume: 4 start-page: 6874 year: 2010 publication-title: ACS Nano – volume: 46 start-page: 1455 year: 2007 publication-title: Angew. Chem. Int. Ed. – volume: 22 start-page: 64 year: 2012 publication-title: J. Mater. Chem. – volume: 35 start-page: 1084 year: 2006 publication-title: Chem. Soc. Rev. – volume: 32 start-page: 1657 year: 2011 publication-title: Biomaterials – volume: 3 start-page: 364 year: 2012 publication-title: J. Phy. Chem. Lett. – volume: 33 start-page: 989 year: 2012 publication-title: Biomaterials – volume: 60 start-page: 1627 year: 2008 publication-title: Adv. Drug Deliv. Rev. – volume: 5 start-page: 161 year: 2005 publication-title: Nat. Rev. Cancer – volume: 7 start-page: 3563 year: 2011 publication-title: Acta Biomater. – volume: 47 start-page: 9972 year: 2011 publication-title: Chem. Commun. – volume: 116 start-page: 23047 year: 2012 publication-title: J. Phy. Chem. C – volume: 5 start-page: 7462 year: 2011 publication-title: ACS Nano – volume: 133 start-page: 6825 year: 2011 publication-title: J. Am. Chem. Soc. – volume: 161 start-page: 461 year: 2012 publication-title: J. Control. Release – volume: 4 start-page: 6353 year: 2010 publication-title: ACS Nano – volume: 14 start-page: 1821 year: 2008 publication-title: Curr. Pharm. Design – volume: 47 start-page: 7947 year: 2011 publication-title: Chem. Commun. – volume: 24 start-page: 1504 year: 2012 publication-title: Adv. Mater. – volume: 42 start-page: 1692 year: 2003 publication-title: Angew. Chem. Int. Ed. – volume: 114 start-page: 10834 year: 1992 publication-title: J. Am. Chem. Soc. – volume: 279 start-page: 548 year: 1998 publication-title: Science – volume: 6 start-page: 1794 year: 2010 publication-title: Small – volume: 24 start-page: 517 year: 2012 publication-title: Chem. Mater. – volume: 358 start-page: 392 year: 2011 publication-title: J. Colloid Interface Sci. – volume: 6 start-page: 2678 year: 2010 publication-title: Small – volume: 127 start-page: 8916 year: 2005 publication-title: J. Am. Chem. Soc. – volume: 133 start-page: 19582 year: 2011 publication-title: J. Am. Chem. Soc. – volume: 130 start-page: 14418 year: 2008 publication-title: J. Am. Chem. Soc. – volume: 359 start-page: 710 year: 1992 publication-title: Nature – volume: 6 start-page: 2104 year: 2012 publication-title: ACS Nano – volume: 113 start-page: 12753 year: 2009 end-page: 12758 publication-title: J. Phys. Chem. C – volume: 1 start-page: 266 year: 2010 publication-title: Medchemcomm – volume: 21 start-page: 3949 year: 2009 publication-title: Adv. Mater. – volume: 3 start-page: 609 year: 2003 publication-title: Nano Lett. – volume: 47 start-page: 3442 year: 2011 publication-title: Chem. Commun. – volume: 4 start-page: 11 year: 2004 publication-title: Nano Lett. – volume: 2 start-page: 791 year: 2008 publication-title: ACS Nano – volume: 26 start-page: 3596 year: 2010 publication-title: Langmuir – volume: 63 start-page: 141 year: 2011 publication-title: J. Pharm. Pharm. – volume: 60 start-page: 1600 year: 2008 publication-title: Adv. Drug Deliv. Rev. – volume: 23 start-page: 2629 year: 2008 publication-title: Chem. Commun. – volume: 33 start-page: 4370 year: 2012 publication-title: Biomaterials – volume: 17 start-page: 5999 year: 2005 publication-title: Chem. Mater. – volume: 130 start-page: 28 year: 2008 publication-title: J. Am. Chem. Soc. – volume: 62 start-page: 346 year: 2010 publication-title: Adv. Drug Deliv. Rev. – volume: 19 start-page: 6267 year: 2009 publication-title: J. Mater. Chem. – volume: 18 start-page: 3083 year: 2006 publication-title: Adv. Mater. – volume: 126 start-page: 187 year: 2008 publication-title: J. Control. Release – volume: 24 start-page: 1418 year: 2012 publication-title: Adv. Mater. – volume: 47 start-page: 12578 year: 2011 publication-title: Chem. Commun. – volume: 31 start-page: 5564 year: 2010 publication-title: Biomaterials – volume: 250 start-page: 371 year: 2009 publication-title: Radiology – volume: 133 start-page: 2955 year: 2011 publication-title: J. Am. Chem. Soc. – volume: 24 start-page: 6433 year: 2012 publication-title: Adv. Mater. – volume: 9 start-page: 3308 year: 2009 publication-title: Nano Lett. – volume: 20 start-page: 4777 year: 2008 publication-title: Chem. Mater. – volume: 163 start-page: 46 year: 2012 publication-title: J. Control. Release – volume: 6 start-page: 1952 year: 2010 publication-title: Small – volume: 34 start-page: 276 year: 2005 publication-title: Chem. Soc. Rev. – volume: 64 start-page: 1800 year: 2012 publication-title: Adv. Drug Deliv. Rev. – volume: 2 start-page: 751 year: 2007 publication-title: Nat. Nanotechnol. – volume: 34 start-page: 181 year: 2013 publication-title: Biomaterials – volume: 49 start-page: 7281 year: 2010 publication-title: Angew. Chem. Int. Ed. – volume: 2 start-page: 889 year: 2008 publication-title: ACS Nano – volume: 3 start-page: 4069 year: 2011 publication-title: Nanoscale – volume: 33 start-page: 2399 year: 2012 publication-title: Biomaterials – volume: 4 start-page: 4539 year: 2010 publication-title: ACS Nano – volume: 50 start-page: 10589 year: 2011 publication-title: Angew. Chem. Int. Ed. – volume: 41 start-page: 2590 year: 2012 publication-title: Chem. Soc. Rev. – volume: 22 start-page: 1586 year: 2012 end-page: 1597 publication-title: Adv. Funct. Mater. – volume: 108 start-page: 2064 year: 2008 publication-title: Chem. Rev. – volume: 33 start-page: 2388 year: 2012 publication-title: Biomaterials – volume: 130 start-page: 2382 year: 2008 publication-title: J. Am. Chem. Soc. – volume: 41 start-page: 2545 year: 2012 publication-title: Chem. Soc. Rev. – volume: 33 start-page: 7126 year: 2012 publication-title: Biomaterials – volume: 31 start-page: 7078 year: 2010 publication-title: Biomaterials – volume: 19 start-page: 4764 year: 2009 publication-title: J. Mater. Chem. – volume: 2 start-page: 295 year: 2007 publication-title: Nat. Nanotechnol. – volume: 238 start-page: 280 year: 2009 publication-title: Toxicol. Appl. Pharm. – ident: e_1_2_7_226_2 doi: 10.1016/j.taap.2009.04.010 – ident: e_1_2_7_119_2 doi: 10.1002/smll.200900923 – ident: e_1_2_7_63_2 doi: 10.1021/ja028650l – ident: e_1_2_7_184_2 doi: 10.1002/adma.201103343 – ident: e_1_2_7_26_2 doi: 10.1021/cm0705789 – ident: e_1_2_7_30_2 doi: 10.1038/nnano.2007.387 – ident: e_1_2_7_77_2 doi: 10.1021/nn2039643 – ident: e_1_2_7_135_2 doi: 10.1021/ja910846q – ident: e_1_2_7_24_2 doi: 10.1021/ja1022267 – ident: e_1_2_7_74_2 doi: 10.1021/ja809346n – ident: e_1_2_7_97_2 doi: 10.1039/b905158a – ident: e_1_2_7_160_2 doi: 10.1038/nature01362 – ident: e_1_2_7_35_2 doi: 10.1016/S1748-0132(07)70084-1 – ident: e_1_2_7_64_2 doi: 10.1038/nmat2992 – ident: e_1_2_7_40_2 doi: 10.1016/j.addr.2009.11.007 – ident: e_1_2_7_84_2 doi: 10.1021/ja051113r – ident: e_1_2_7_66_2 doi: 10.1002/smll.201001459 – ident: e_1_2_7_164_2 doi: 10.1002/anie.200501819 – ident: e_1_2_7_192_2 doi: 10.1038/nrc1591 – ident: e_1_2_7_88_2 doi: 10.1002/chem.201102599 – ident: e_1_2_7_222_2 doi: 10.1016/j.addr.2012.06.006 – ident: e_1_2_7_25_2 doi: 10.1002/adma.201101586 – ident: e_1_2_7_154_2 doi: 10.1002/jbm.a.31923 – ident: e_1_2_7_232_2 doi: 10.1039/c0jm03915b – ident: e_1_2_7_103_2 doi: 10.1002/smll.200901789 – ident: e_1_2_7_48_2 – ident: e_1_2_7_140_2 doi: 10.1002/adfm.200701317 – ident: e_1_2_7_15_2 doi: 10.1002/anie.201106180 – ident: e_1_2_7_56_2 doi: 10.1021/nn1029229 – ident: e_1_2_7_136_2 doi: 10.1016/j.biomaterials.2011.12.008 – ident: e_1_2_7_108_2 doi: 10.1021/ar600032u – ident: e_1_2_7_171_2 doi: 10.1021/jp9043978 – ident: e_1_2_7_9_2 doi: 10.1002/anie.200604488 – ident: e_1_2_7_49_2 doi: 10.2174/138161208784746671 – ident: e_1_2_7_7_2 doi: 10.1096/fj.04-2747rev – ident: e_1_2_7_197_2 doi: 10.1016/j.biomaterials.2010.11.025 – ident: e_1_2_7_3_2 doi: 10.1021/cr0300789 – ident: e_1_2_7_203_2 doi: 10.1021/cr9004007 – ident: e_1_2_7_72_2 doi: 10.1021/ja211035w – ident: e_1_2_7_12_2 doi: 10.1021/nl0502569 – ident: e_1_2_7_131_2 doi: 10.1016/j.micromeso.2010.01.009 – ident: e_1_2_7_113_2 doi: 10.1039/b9nr00162j – ident: e_1_2_7_86_2 doi: 10.1002/adma.201104797 – ident: e_1_2_7_193_2 doi: 10.1259/bjr/17150274 – ident: e_1_2_7_4_2 doi: 10.1038/nrc1566 – ident: e_1_2_7_180_2 doi: 10.1016/j.micromeso.2009.03.031 – ident: e_1_2_7_241_2 doi: 10.1002/adfm.201002337 – ident: e_1_2_7_208_2 doi: 10.1021/nn200306g – ident: e_1_2_7_244_2 doi: 10.1016/j.biomaterials.2011.10.017 – ident: e_1_2_7_204_2 doi: 10.1021/cr900232t – ident: e_1_2_7_68_2 doi: 10.1016/j.biomaterials.2009.10.046 – ident: e_1_2_7_114_2 doi: 10.1016/j.addr.2012.05.008 – ident: e_1_2_7_248_2 doi: 10.1002/smll.201100521 – ident: e_1_2_7_73_2 doi: 10.1021/nn700008s – ident: e_1_2_7_125_2 doi: 10.1016/j.jconrel.2011.10.037 – ident: e_1_2_7_127_2 doi: 10.1002/smll.201000538 – ident: e_1_2_7_87_2 doi: 10.1002/adma.201104714 – ident: e_1_2_7_217_2 doi: 10.1021/ja001106x – ident: e_1_2_7_104_2 doi: 10.1021/jz2013837 – ident: e_1_2_7_150_2 doi: 10.1021/mp200287c – ident: e_1_2_7_175_2 doi: 10.1002/anie.201004133 – ident: e_1_2_7_21_2 doi: 10.1016/j.addr.2008.08.003 – ident: e_1_2_7_109_2 doi: 10.1002/adma.201104763 – ident: e_1_2_7_112_2 doi: 10.1002/adfm.200601191 – ident: e_1_2_7_231_2 doi: 10.1016/j.biomaterials.2012.02.056 – ident: e_1_2_7_27_2 doi: 10.1016/j.solidstatesciences.2007.11.026 – ident: e_1_2_7_224_2 doi: 10.1039/c0cc05520d – ident: e_1_2_7_230_2 doi: 10.1039/c1cc11479d – ident: e_1_2_7_138_2 doi: 10.1021/nn202399w – ident: e_1_2_7_221_2 doi: 10.1016/j.jconrel.2011.05.017 – ident: e_1_2_7_101_2 doi: 10.1039/c2cs15308d – ident: e_1_2_7_137_2 doi: 10.1021/tx300166u – ident: e_1_2_7_229_2 doi: 10.1021/cr200355j – ident: e_1_2_7_2_2 doi: 10.1021/cr030698 – ident: e_1_2_7_246_2 doi: 10.2147/IJN.S26547 – ident: e_1_2_7_155_2 doi: 10.1002/anie.201203993 – ident: e_1_2_7_13_2 doi: 10.1021/cr000108x – ident: e_1_2_7_242_2 doi: 10.1021/nl202949y – ident: e_1_2_7_188_2 doi: 10.1039/c0jm00645a – ident: e_1_2_7_146_2 doi: 10.1021/nn100918a – ident: e_1_2_7_130_2 doi: 10.1016/j.micromeso.2009.11.015 – ident: e_1_2_7_96_2 doi: 10.1021/nl901589y – ident: e_1_2_7_174_2 doi: 10.1021/nn101499d – ident: e_1_2_7_190_2 doi: 10.1016/j.nantod.2011.10.003 – ident: e_1_2_7_205_2 doi: 10.1039/b902685a – ident: e_1_2_7_165_2 doi: 10.1021/ja8060886 – ident: e_1_2_7_102_2 doi: 10.1016/j.addr.2008.03.012 – ident: e_1_2_7_93_2 doi: 10.1016/j.biomaterials.2012.06.059 – ident: e_1_2_7_194_2 doi: 10.1259/0007-1285-68-816-1296 – ident: e_1_2_7_200_2 doi: 10.1002/jbm.a.31371 – ident: e_1_2_7_50_2 doi: 10.2174/156720111797635522 – ident: e_1_2_7_191_2 doi: 10.1002/adma.201104033 – ident: e_1_2_7_75_2 doi: 10.1021/cm702792e – ident: e_1_2_7_82_2 doi: 10.1021/ja0777584 – ident: e_1_2_7_215_2 doi: 10.1002/anie.201103108 – ident: e_1_2_7_159_2 doi: 10.1016/j.jconrel.2007.12.017 – ident: e_1_2_7_31_2 doi: 10.1039/c2cs15327k – ident: e_1_2_7_134_2 doi: 10.1038/nbt1340 – ident: e_1_2_7_43_2 doi: 10.1021/ja2010175 – ident: e_1_2_7_79_2 doi: 10.1021/nl034134x – ident: e_1_2_7_142_2 doi: 10.1016/j.micromeso.2005.05.001 – ident: e_1_2_7_216_2 doi: 10.1002/ejic.201101163 – ident: e_1_2_7_41_2 doi: 10.1039/c2cs15355f – ident: e_1_2_7_59_2 doi: 10.1038/359710a0 – ident: e_1_2_7_106_2 doi: 10.1039/c1cc11760b – ident: e_1_2_7_167_2 doi: 10.1002/anie.200603404 – ident: e_1_2_7_78_2 doi: 10.1002/smll.201200028 – ident: e_1_2_7_81_2 doi: 10.1002/adma.200900599 – ident: e_1_2_7_91_2 doi: 10.1021/ja710193c – ident: e_1_2_7_126_2 doi: 10.1021/nn2043803 – ident: e_1_2_7_53_2 doi: 10.1002/adma.201201742 – ident: e_1_2_7_22_2 doi: 10.1016/j.addr.2008.08.004 – ident: e_1_2_7_129_2 doi: 10.1016/j.biomaterials.2010.10.035 – ident: e_1_2_7_144_2 doi: 10.1039/b822444g – ident: e_1_2_7_44_2 doi: 10.1016/S1369-7021(11)70161-4 – ident: e_1_2_7_20_2 doi: 10.1021/ja057254a – ident: e_1_2_7_34_2 doi: 10.1021/cr068445e – ident: e_1_2_7_76_2 doi: 10.1021/nn103130q – ident: e_1_2_7_189_2 doi: 10.1002/anie.201104765 – ident: e_1_2_7_179_2 doi: 10.1039/b902985k – ident: e_1_2_7_199_2 doi: 10.1016/j.solidstatesciences.2005.04.003 – ident: e_1_2_7_177_2 doi: 10.1021/ja9061085 – ident: e_1_2_7_28_2 doi: 10.1016/j.actbio.2011.06.028 – ident: e_1_2_7_234_2 doi: 10.1016/j.jcis.2011.03.051 – ident: e_1_2_7_95_2 doi: 10.1002/smll.200902355 – ident: e_1_2_7_213_2 doi: 10.1021/cr100025t – ident: e_1_2_7_99_2 doi: 10.1021/ja905793q – year: 2013 ident: e_1_2_7_57_2 publication-title: Adv. Mater. – ident: e_1_2_7_36_2 doi: 10.1126/science.1104274 – ident: e_1_2_7_58_2 doi: 10.1021/ja00053a020 – ident: e_1_2_7_166_2 doi: 10.1021/cm051198v – year: 2008 ident: e_1_2_7_198_2 publication-title: J. Nanomater. – ident: e_1_2_7_124_2 doi: 10.2217/nnm.11.19 – ident: e_1_2_7_85_2 doi: 10.1021/ja0565875 – ident: e_1_2_7_17_2 doi: 10.1021/jp306543q – ident: e_1_2_7_67_2 doi: 10.1021/nn200809t – ident: e_1_2_7_212_2 doi: 10.1148/radiol.2502080498 – ident: e_1_2_7_46_2 doi: 10.1088/0957-4484/20/4/045602 – ident: e_1_2_7_60_2 doi: 10.1126/science.279.5350.548 – ident: e_1_2_7_14_2 doi: 10.1002/adma.201104033 – ident: e_1_2_7_65_2 doi: 10.1002/cbic.200700509 – ident: e_1_2_7_223_2 doi: 10.1016/j.biomaterials.2012.02.060 – ident: e_1_2_7_10_2 doi: 10.1021/cr940351u – ident: e_1_2_7_16_2 doi: 10.1016/j.biomaterials.2012.09.029 – ident: e_1_2_7_172_2 doi: 10.1002/adma.200600387 – ident: e_1_2_7_233_2 doi: 10.1039/c0md00139b – volume: 98 year: 2011 ident: e_1_2_7_247_2 publication-title: Appl. Phys. Lett. – ident: e_1_2_7_245_2 doi: 10.1021/nn200372g – ident: e_1_2_7_8_2 doi: 10.1038/nrclinonc.2010.139 – ident: e_1_2_7_169_2 doi: 10.1002/anie.201002639 – ident: e_1_2_7_105_2 doi: 10.1021/ar2000259 – ident: e_1_2_7_209_2 doi: 10.1021/ja1084095 – ident: e_1_2_7_201_2 doi: 10.1016/j.biomaterials.2009.01.029 – ident: e_1_2_7_214_2 doi: 10.1007/3-540-45733-X_6 – ident: e_1_2_7_195_2 doi: 10.1016/S0022-5347(05)64992-0 – ident: e_1_2_7_47_2 doi: 10.2217/nnm.11.166 – ident: e_1_2_7_238_2 doi: 10.1016/j.addr.2012.06.012 – ident: e_1_2_7_145_2 doi: 10.1002/smll.201101055 – ident: e_1_2_7_219_2 doi: 10.1021/nn202863x – ident: e_1_2_7_152_2 doi: 10.1021/nn100690m – ident: e_1_2_7_39_2 doi: 10.1021/ar800018v – ident: e_1_2_7_123_2 doi: 10.1038/nrd1033 – ident: e_1_2_7_115_2 doi: 10.1002/smll.200800926 – ident: e_1_2_7_132_2 doi: 10.1021/cm3001688 – ident: e_1_2_7_122_2 doi: 10.1016/j.nano.2011.06.002 – ident: e_1_2_7_141_2 doi: 10.1016/j.micromeso.2005.06.015 – ident: e_1_2_7_128_2 doi: 10.1016/j.biomaterials.2008.07.007 – ident: e_1_2_7_23_2 doi: 10.1016/j.addr.2003.07.013 – ident: e_1_2_7_227_2 doi: 10.1016/j.biomaterials.2010.05.065 – ident: e_1_2_7_139_2 doi: 10.1002/anie.200501500 – ident: e_1_2_7_173_2 doi: 10.1002/anie.200900880 – ident: e_1_2_7_89_2 doi: 10.1002/adfm.200800753 – ident: e_1_2_7_178_2 doi: 10.1021/cm703363w – ident: e_1_2_7_170_2 doi: 10.1093/nar/gkq893 – ident: e_1_2_7_61_2 doi: 10.1021/cr068020s – ident: e_1_2_7_45_2 doi: 10.1039/c1nr10718f – ident: e_1_2_7_185_2 doi: 10.1002/anie.201002820 – ident: e_1_2_7_1_2 doi: 10.1002/anie.200802585 – ident: e_1_2_7_92_2 doi: 10.1002/smll.200701316 – ident: e_1_2_7_116_2 doi: 10.1021/ja201779d – ident: e_1_2_7_181_2 doi: 10.1021/ja904456d – ident: e_1_2_7_147_2 doi: 10.1039/c2nr12094a – ident: e_1_2_7_149_2 doi: 10.1039/c0jm04115g – ident: e_1_2_7_240_2 doi: 10.1021/nn800072t – ident: e_1_2_7_19_2 doi: 10.1039/b517615h – ident: e_1_2_7_70_2 doi: 10.1016/j.biomaterials.2009.09.060 – ident: e_1_2_7_71_2 doi: 10.1021/nn901398j – ident: e_1_2_7_225_2 doi: 10.1021/nl0347334 – ident: e_1_2_7_163_2 doi: 10.1021/ja807798g – ident: e_1_2_7_211_2 doi: 10.1021/nl902715v – ident: e_1_2_7_29_2 doi: 10.1039/C1JM13102H – ident: e_1_2_7_120_2 doi: 10.1021/nn200365a – ident: e_1_2_7_210_2 doi: 10.1038/ncpneph0660 – ident: e_1_2_7_33_2 doi: 10.1039/b402025a – ident: e_1_2_7_236_2 doi: 10.1016/j.biomaterials.2012.03.066 – ident: e_1_2_7_207_2 doi: 10.1002/anie.200602866 – ident: e_1_2_7_6_2 doi: 10.1038/nbt1006-1211 – ident: e_1_2_7_239_2 doi: 10.1002/adfm.201001495 – ident: e_1_2_7_100_2 doi: 10.1039/c0jm03851b – ident: e_1_2_7_182_2 doi: 10.1021/ja901831u – ident: e_1_2_7_32_2 doi: 10.1002/adfm.201102052 – ident: e_1_2_7_220_2 doi: 10.1016/S1476-5586(03)80005-2 – ident: e_1_2_7_157_2 doi: 10.1016/j.addr.2006.09.020 – ident: e_1_2_7_162_2 doi: 10.1039/c0cc02914a – ident: e_1_2_7_202_2 doi: 10.1016/j.biomaterials.2010.07.103 – ident: e_1_2_7_110_2 doi: 10.1039/c1cs15246g – ident: e_1_2_7_121_2 doi: 10.1016/j.biomaterials.2010.04.055 – ident: e_1_2_7_51_2 doi: 10.1172/JCI45600 – ident: e_1_2_7_94_2 doi: 10.1016/j.biomaterials.2011.11.086 – ident: e_1_2_7_80_2 doi: 10.1002/adma.200800854 – ident: e_1_2_7_161_2 doi: 10.1021/ja900025f – ident: e_1_2_7_156_2 doi: 10.1021/ja206998x – ident: e_1_2_7_228_2 doi: 10.1039/C1CS15187H – ident: e_1_2_7_38_2 doi: 10.1038/nbt994 – ident: e_1_2_7_158_2 doi: 10.1039/B406727D – ident: e_1_2_7_168_2 doi: 10.1021/jp103982a – ident: e_1_2_7_176_2 doi: 10.1021/ja0772086 – ident: e_1_2_7_218_2 doi: 10.1016/j.biomaterials.2012.05.065 – ident: e_1_2_7_55_2 doi: 10.1002/anie.201001847 – ident: e_1_2_7_151_2 doi: 10.1002/smll.200900621 – ident: e_1_2_7_183_2 doi: 10.1021/ar200106e – ident: e_1_2_7_186_2 doi: 10.1093/jnci/90.12.889 – ident: e_1_2_7_237_2 doi: 10.1002/adfm.201100031 – ident: e_1_2_7_243_2 doi: 10.1002/adfm.200500565 – ident: e_1_2_7_206_2 doi: 10.1039/C1CS15248C – ident: e_1_2_7_117_2 doi: 10.1016/j.jconrel.2012.05.046 – ident: e_1_2_7_98_2 doi: 10.1021/nn800781r – ident: e_1_2_7_90_2 doi: 10.1021/la903008z – ident: e_1_2_7_153_2 doi: 10.1038/nnano.2007.108 – ident: e_1_2_7_118_2 doi: 10.1016/j.biomaterials.2010.01.015 – ident: e_1_2_7_143_2 doi: 10.1039/b804594a – ident: e_1_2_7_11_2 doi: 10.1016/j.nantod.2011.02.007 – ident: e_1_2_7_250_2 doi: 10.1021/nn1015117 – ident: e_1_2_7_196_2 doi: 10.1016/j.progsolidstchem.2007.10.002 – ident: e_1_2_7_111_2 doi: 10.1039/c1cc13658e – ident: e_1_2_7_69_2 doi: 10.1021/cm0204371 – ident: e_1_2_7_52_2 doi: 10.1021/cm203000u – ident: e_1_2_7_62_2 doi: 10.1021/cm0011559 – ident: e_1_2_7_235_2 doi: 10.1002/adma.200901096 – ident: e_1_2_7_249_2 doi: 10.1002/smll.201001447 – ident: e_1_2_7_133_2 doi: 10.1016/j.biomaterials.2010.03.048 – ident: e_1_2_7_18_2 doi: 10.1021/ar800150g – ident: e_1_2_7_83_2 doi: 10.1002/anie.200802469 – ident: e_1_2_7_187_2 doi: 10.1038/nrc1071 – ident: e_1_2_7_37_2 doi: 10.1038/nmat1390 – ident: e_1_2_7_54_2 doi: 10.1002/anie.201000827 – ident: e_1_2_7_42_2 doi: 10.1111/j.2042-7158.2010.01167.x – ident: e_1_2_7_107_2 doi: 10.1002/chem.200600226 – ident: e_1_2_7_5_2 doi: 10.1002/anie.200200546 – ident: e_1_2_7_148_2 doi: 10.1039/c0jm02863k |
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| SubjectTerms | Animals Antineoplastic Agents - administration & dosage Biocompatibility Biocompatible Materials - chemistry Biomaterials Biomedical materials Contrast Media diagnosis Drug Carriers - chemistry Humans In vivo In vivo testing In vivo tests Lipid Bilayers - metabolism mesoporous silica Nanocomposites nanomedicine Nanoparticles - chemistry Nanostructure Neoplasms - diagnosis Neoplasms - diagnostic imaging Neoplasms - drug therapy Porosity RNA, Small Interfering - administration & dosage Silicon Dioxide - chemistry Surgical implants therapy Tissue Engineering Ultrasonography |
| Title | In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles |
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