Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma

• Published in: Hepatology (Baltimore, Md.) Vol. 60; no. 5; pp. 1645 - 1658
• Main Authors: Wong, Carmen Chak‐Lui, Tse, Aki Pui‐Wah, Huang, Yan‐Ping, Zhu, Yan‐Ting, Chiu, David Kung‐Chun, Lai, Robin Kit‐Ho, Au, Sandy Leung‐Kuen, Kai, Alan Ka‐Lun, Lee, Joyce Man‐Fong, Wei, Larry Lai, Tsang, Felice Ho‐Ching, Lo, Regina Cheuk‐Lam, Shi, Jue, Zheng, Yong‐Ping, Wong, Chun‐Ming, Ng, Irene Oi‐Lin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.11.2014
• Subjects: Amino Acid Oxidoreductases - metabolism; Animals; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - enzymology; Case-Control Studies; Cell Adhesion; Cell Line, Tumor; Collagen - metabolism; Female; Hepatology; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Liver cancer; Liver cirrhosis; Liver Neoplasms, Experimental - enzymology; Male; Metastasis; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - metabolism; Neoplasm Metastasis; Smad4 Protein - metabolism; Transplants & implants; Tumor Microenvironment

Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated with metastasis; however, the underlying mechanisms remain poorly understood. This article investigates the role of lysyl oxidase‐like 2 (LOXL‐2) in the biology of HCC metastasis. First, we showed that HCC meta...