Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3 × Tg-AD mice

• Published in: Scientific reports Vol. 12; no. 1; p. 996
• Main Authors: Konishi, Fumiko, Furusho, Tadasu, Soeda, Yoshiyuki, Yamauchi, Jun, Kobayashi, Shoko, Ito, Masatoshi, Araki, Takuma, Kogure, Sarasa, Takashima, Akihiko, Takekoshi, Susumu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/375; 692/700/459; Accumulation; Alzheimer Disease - drug therapy; Alzheimer Disease - genetics; Alzheimer's disease; Amyloid beta-Peptides - analysis; Animals; Beans; Brain Chemistry - drug effects; Cognition - drug effects; Cognitive ability; Diet - veterinary; Dihydroxyphenylalanine; Disease Models, Animal; Female; Humanities and Social Sciences; Levodopa; Levodopa - analysis; Mice, Transgenic; Mucuna; Mucuna - chemistry; multidisciplinary; Neurodegenerative diseases; Neurofibrillary tangles; Peptides; Science; Science (multidisciplinary); Senile plaques; Tau protein; tau Proteins - analysis; Transgenic mice

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (Aβ) resulting in senile plaques and intracellular hyperphosphorylated tau protein resulting in neurofibrillary tangles (NFTs). Mucuna beans ( Mucuna pruriences (L.) DC....