Optimizing adrenal vein sampling in primary aldosteronism subtyping through LC–MS/MS and secretion ratios of aldosterone, 18-oxocortisol, and 18-hydroxycortisol

• Published in: Hypertension research Vol. 46; no. 8; pp. 1983 - 1994
• Main Authors: Chang, Yu-Ling, Chen, Guan-Yuan, Lee, Bo-Ching, Chen, Po-Ting, Liu, Kao-Lang, Chang, Chin-Chen, Weng, Te-I, Wu, Vin-Cent, Lin, Yen-Hung
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.08.2023; Springer Nature Singapore
• Subjects: Adrenocorticotropic Hormone; Aldosterone; Chromatography, Liquid; Endocrine disorders; Humans; Hydrocortisone; Hyperaldosteronism - diagnosis; Immunoassay; Ratios; Retrospective Studies; Steroids; Tandem Mass Spectrometry; Veins & arteries; Adrenal glands; Hyperaldosteronism; Aldosterone; Mass spectrometry

Adrenal venous sampling (AVS) is the gold standard for identifying curable unilateral aldosterone excess in primary aldosteronism (PA). Studies have demonstrated the value of steroid profiling through liquid chromatography–tandem mass spectrometry (LC–MS/MS) in AVS interpretation. First, the perform...