Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers

• Published in: Cancer discovery Vol. 3; no. 7; pp. 770 - 781
• Main Authors: Pickering, Curtis R, Zhang, Jiexin, Yoo, Suk Young, Bengtsson, Linnea, Moorthy, Shhyam, Neskey, David M, Zhao, Mei, Ortega Alves, Marcus V, Chang, Kyle, Drummond, Jennifer, Cortez, Elsa, Xie, Tong-Xin, Zhang, Di, Chung, Woonbok, Issa, Jean-Pierre J, Zweidler-McKay, Patrick A, Wu, Xifeng, El-Naggar, Adel K, Weinstein, John N, Wang, Jing, Muzny, Donna M, Gibbs, Richard A, Wheeler, David A, Myers, Jeffrey N, Frederick, Mitchell J
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Caspase 8 - genetics; Caspase 8 - metabolism; Cell Line, Tumor; DNA Copy Number Variations - genetics; DNA Methylation - genetics; Gene Expression Regulation, Neoplastic - genetics; Genomics; Humans; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Point Mutation - genetics; Receptors, Notch - genetics; Receptors, Notch - metabolism

The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to search for promising molecular targets. To this end, we conducted comprehensive genomic analysis of gene expression, copy number, methylation, a...