Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers
The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to search for promising molecular targets. To this end, we conducted comprehensive genomic analysis of gene expression, copy number, methylation, a...
Saved in:
| Published in | Cancer discovery Vol. 3; no. 7; pp. 770 - 781 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.07.2013
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to search for promising molecular targets. To this end, we conducted comprehensive genomic analysis of gene expression, copy number, methylation, and point mutations in OSCC. Integrated analysis revealed more somatic events than previously reported, identifying four major driver pathways (mitogenic signaling, Notch, cell cycle, and TP53) and two additional key genes (FAT1, CASP8). The Notch pathway was defective in 66% of patients, and in follow-up studies of mechanism, functional NOTCH1 signaling inhibited proliferation of OSCC cell lines. Frequent mutation of caspase-8 (CASP8) defines a new molecular subtype of OSCC with few copy number changes. Although genomic alterations are dominated by loss of tumor suppressor genes, 80% of patients harbored at least one genomic alteration in a targetable gene, suggesting that novel approaches to treatment may be possible for this debilitating subset of head and neck cancers. |
|---|---|
| AbstractList | The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to search for promising molecular targets. To this end, we conducted comprehensive genomic analysis of gene expression, copy number, methylation, and point mutations in OSCC. Integrated analysis revealed more somatic events than previously reported, identifying four major driver pathways (mitogenic signaling, Notch, cell cycle, and TP53) and two additional key genes (FAT1, CASP8). The Notch pathway was defective in 66% of patients, and in follow-up studies of mechanism, functional NOTCH1 signaling inhibited proliferation of OSCC cell lines. Frequent mutation of caspase-8 (CASP8) defines a new molecular subtype of OSCC with few copy number changes. Although genomic alterations are dominated by loss of tumor suppressor genes, 80% of patients harbored at least one genomic alteration in a targetable gene, suggesting that novel approaches to treatment may be possible for this debilitating subset of head and neck cancers.
Significance: This is the first integrated genomic analysis of OSCC. Only through integrated multiplatform analysis was it possible to identify four key pathways. We also discovered a new disease subtype associated with CASP8 and HRAS mutation. Finally, many candidate targetable events were found and provide hope for future genomically driven therapeutic strategies. Cancer Discov; 3(7); 770–81. ©2013 AACR.
See related commentary by Iglesias-Bartolome et al., p. 722
This article is highlighted in the In This Issue feature, p. 705 The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to search for promising molecular targets. To this end, we conducted comprehensive genomic analysis of gene expression, copy number, methylation, and point mutations in OSCC. Integrated analysis revealed more somatic events than previously reported, identifying four major driver pathways (mitogenic signaling, Notch, cell cycle, and TP53) and two additional key genes (FAT1, CASP8). The Notch pathway was defective in 66% of patients, and in follow-up studies of mechanism, functional NOTCH1 signaling inhibited proliferation of OSCC cell lines. Frequent mutation of caspase-8 (CASP8) defines a new molecular subtype of OSCC with few copy number changes. Although genomic alterations are dominated by loss of tumor suppressor genes, 80% of patients harbored at least one genomic alteration in a targetable gene, suggesting that novel approaches to treatment may be possible for this debilitating subset of head and neck cancers. |
| Author | Pickering, Curtis R Chung, Woonbok Zhang, Jiexin Drummond, Jennifer Muzny, Donna M Moorthy, Shhyam Issa, Jean-Pierre J Yoo, Suk Young El-Naggar, Adel K Chang, Kyle Gibbs, Richard A Xie, Tong-Xin Wheeler, David A Ortega Alves, Marcus V Myers, Jeffrey N Zweidler-McKay, Patrick A Weinstein, John N Zhang, Di Wu, Xifeng Neskey, David M Zhao, Mei Cortez, Elsa Wang, Jing Bengtsson, Linnea Frederick, Mitchell J |
| Author_xml | – sequence: 1 givenname: Curtis R surname: Pickering fullname: Pickering, Curtis R organization: Departments of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA – sequence: 2 givenname: Jiexin surname: Zhang fullname: Zhang, Jiexin – sequence: 3 givenname: Suk Young surname: Yoo fullname: Yoo, Suk Young – sequence: 4 givenname: Linnea surname: Bengtsson fullname: Bengtsson, Linnea – sequence: 5 givenname: Shhyam surname: Moorthy fullname: Moorthy, Shhyam – sequence: 6 givenname: David M surname: Neskey fullname: Neskey, David M – sequence: 7 givenname: Mei surname: Zhao fullname: Zhao, Mei – sequence: 8 givenname: Marcus V surname: Ortega Alves fullname: Ortega Alves, Marcus V – sequence: 9 givenname: Kyle surname: Chang fullname: Chang, Kyle – sequence: 10 givenname: Jennifer surname: Drummond fullname: Drummond, Jennifer – sequence: 11 givenname: Elsa surname: Cortez fullname: Cortez, Elsa – sequence: 12 givenname: Tong-Xin surname: Xie fullname: Xie, Tong-Xin – sequence: 13 givenname: Di surname: Zhang fullname: Zhang, Di – sequence: 14 givenname: Woonbok surname: Chung fullname: Chung, Woonbok – sequence: 15 givenname: Jean-Pierre J surname: Issa fullname: Issa, Jean-Pierre J – sequence: 16 givenname: Patrick A surname: Zweidler-McKay fullname: Zweidler-McKay, Patrick A – sequence: 17 givenname: Xifeng surname: Wu fullname: Wu, Xifeng – sequence: 18 givenname: Adel K surname: El-Naggar fullname: El-Naggar, Adel K – sequence: 19 givenname: John N surname: Weinstein fullname: Weinstein, John N – sequence: 20 givenname: Jing surname: Wang fullname: Wang, Jing – sequence: 21 givenname: Donna M surname: Muzny fullname: Muzny, Donna M – sequence: 22 givenname: Richard A surname: Gibbs fullname: Gibbs, Richard A – sequence: 23 givenname: David A surname: Wheeler fullname: Wheeler, David A – sequence: 24 givenname: Jeffrey N surname: Myers fullname: Myers, Jeffrey N – sequence: 25 givenname: Mitchell J surname: Frederick fullname: Frederick, Mitchell J |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23619168$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kElPwzAUhC1UREvpP0DIRy4pXrL5iMpWqRKX3i3HfmmNkri1EyT49ThqqS9e5s149N2iSec6QOiekiWlWfnEaCaSkgmy1CahLCEZL67Q7PI8uZyLdIoWIXyRuFKRZqS4QVPGcypoXs7Qft31sPOqt9-Ad9C51mqs98or3YO3v1FwHXY1dl41OBwH1bohYA1Ng7Xy2kaHwtZA19vaQsC1h-MQbzhEoY9hxsdoH-7Qda2aAIvzPkfbt9ft6iPZfL6vV8-bRGeM9kltTA6GF2XFUqGg1JlIlSoNpUVlyijpIq8UFyTlhNXCqAoMKJYJoUmuCZ-jx1PswbvYI_SytWFsqzqIxSXlQghO8zyPo-lpVHsXgodaHrxtlf-RlMiRshwRyhGnXL1IyuRIOdoezj8MVQvmYvpnyv8AO0V9Ow |
| CitedBy_id | crossref_primary_10_1158_1078_0432_CCR_13_3310 crossref_primary_10_1002_lio2_175 crossref_primary_10_1093_carcin_bgy107 crossref_primary_10_1002_cam4_307 crossref_primary_10_1002_lio2_86 crossref_primary_10_1016_j_oraloncology_2018_04_006 crossref_primary_10_3233_CBM_203086 crossref_primary_10_1002_cncr_33101 crossref_primary_10_3390_ijms22052402 crossref_primary_10_1186_s40001_022_00916_4 crossref_primary_10_1111_jop_12985 crossref_primary_10_3892_or_2015_4402 crossref_primary_10_1016_j_ijrobp_2013_06_2043 crossref_primary_10_18632_oncoscience_99 crossref_primary_10_1093_jnci_dju215 crossref_primary_10_1002_ame2_12367 crossref_primary_10_1016_j_ejca_2024_113986 crossref_primary_10_1158_2159_8290_CD_13_0239 crossref_primary_10_1016_j_canlet_2016_09_014 crossref_primary_10_1158_0008_5472_CAN_15_3317 crossref_primary_10_1016_j_pharmthera_2019_107448 crossref_primary_10_1038_s41585_018_0005_1 crossref_primary_10_3390_biomedicines10112948 crossref_primary_10_3390_jcm8122131 crossref_primary_10_1016_j_prp_2021_153474 crossref_primary_10_1186_s13073_015_0219_2 crossref_primary_10_1111_jop_12642 crossref_primary_10_1007_s10555_016_9625_1 crossref_primary_10_1111_odi_13155 crossref_primary_10_1093_annonc_mdu143 crossref_primary_10_3389_fgene_2022_870133 crossref_primary_10_1093_annonc_mdw426 crossref_primary_10_3390_cancers15072051 crossref_primary_10_1016_j_oraloncology_2020_104689 crossref_primary_10_1007_s00432_015_2083_2 crossref_primary_10_1007_s13167_019_00177_y crossref_primary_10_1007_s12032_014_0126_1 crossref_primary_10_1371_journal_pone_0154112 crossref_primary_10_3390_jcm7120534 crossref_primary_10_1016_j_ctrv_2024_102773 crossref_primary_10_1200_PO_20_00515 crossref_primary_10_1016_j_currproblcancer_2017_10_001 crossref_primary_10_3389_fmolb_2021_677900 crossref_primary_10_18632_oncotarget_27306 crossref_primary_10_1016_j_oraloncology_2020_105003 crossref_primary_10_3390_cells12222663 crossref_primary_10_1371_journal_pone_0183606 crossref_primary_10_1007_s12079_022_00711_0 crossref_primary_10_1186_s13046_022_02461_8 crossref_primary_10_3389_fimmu_2018_02111 crossref_primary_10_1016_j_mcp_2020_101568 crossref_primary_10_1093_jnci_djz097 crossref_primary_10_3389_fcell_2015_00011 crossref_primary_10_1016_j_oraloncology_2018_05_017 crossref_primary_10_1038_nrc_2016_145 crossref_primary_10_1186_s12957_023_02938_6 crossref_primary_10_18632_oncotarget_11196 crossref_primary_10_18632_oncotarget_2417 crossref_primary_10_18632_oncotarget_2670 crossref_primary_10_1073_pnas_1617816114 crossref_primary_10_3389_fonc_2021_794146 crossref_primary_10_1016_j_bbrc_2017_08_049 crossref_primary_10_1371_journal_pone_0216834 crossref_primary_10_1007_s10528_023_10484_9 crossref_primary_10_1371_journal_pone_0233058 crossref_primary_10_3390_cancers14030834 crossref_primary_10_1158_1541_7786_MCR_20_0688 crossref_primary_10_1007_s12250_021_00413_8 crossref_primary_10_18632_oncotarget_17521 crossref_primary_10_1016_j_oraloncology_2024_106717 crossref_primary_10_1016_j_ccell_2016_04_004 crossref_primary_10_1186_s40463_016_0140_8 crossref_primary_10_1016_j_celrep_2022_111561 crossref_primary_10_1002_ijc_31412 crossref_primary_10_3389_fgene_2021_643461 crossref_primary_10_1038_s41379_018_0126_3 crossref_primary_10_1016_j_ejphar_2020_173201 crossref_primary_10_1016_j_oraloncology_2016_07_015 crossref_primary_10_3390_genes12030422 crossref_primary_10_3389_fonc_2021_587548 crossref_primary_10_1200_JCO_2016_67_5264 crossref_primary_10_7554_eLife_16519 crossref_primary_10_18632_oncotarget_3768 crossref_primary_10_1038_nrd4252 crossref_primary_10_4081_oncol_2022_549 crossref_primary_10_1016_j_radonc_2017_08_001 crossref_primary_10_1007_s13273_021_00117_w crossref_primary_10_1172_JCI82066 crossref_primary_10_1002_jcb_25592 crossref_primary_10_1038_emm_2017_265 crossref_primary_10_1002_jmv_29315 crossref_primary_10_1038_bjc_2014_438 crossref_primary_10_7314_APJCP_2015_16_17_7619 crossref_primary_10_1097_MOO_0000000000000245 crossref_primary_10_5005_jp_journals_10024_3240 crossref_primary_10_1111_odi_12206 crossref_primary_10_1038_s41388_019_0781_y crossref_primary_10_18632_oncotarget_8321 crossref_primary_10_3892_ijo_2022_5453 crossref_primary_10_3390_cancers13112709 crossref_primary_10_2139_ssrn_3804744 crossref_primary_10_1158_1541_7786_MCR_15_0395 crossref_primary_10_1038_srep42105 crossref_primary_10_1158_1078_0432_CCR_17_1302 crossref_primary_10_1111_odi_13540 crossref_primary_10_1159_000381717 crossref_primary_10_1016_j_cpet_2016_08_009 crossref_primary_10_1186_s12885_018_4481_8 crossref_primary_10_1200_JCO_22_02786 crossref_primary_10_3389_fcell_2022_936168 crossref_primary_10_3892_ijo_2018_4667 crossref_primary_10_1177_1010428318793023 crossref_primary_10_3389_fimmu_2023_1240394 crossref_primary_10_1016_j_oraloncology_2018_02_014 crossref_primary_10_12688_f1000research_7302_1 crossref_primary_10_1016_j_ajpath_2021_06_005 crossref_primary_10_1007_s10555_017_9688_7 crossref_primary_10_1186_s12929_023_00953_z crossref_primary_10_1177_0022034518760297 crossref_primary_10_1007_s00784_016_1946_5 crossref_primary_10_1177_0022034518759068 crossref_primary_10_3389_fonc_2022_954037 crossref_primary_10_1002_cncr_33393 crossref_primary_10_1177_0022034520930641 crossref_primary_10_1186_s13578_022_00812_8 crossref_primary_10_1002_cam4_731 crossref_primary_10_1038_srep24704 crossref_primary_10_1158_2159_8290_CD_14_1205 crossref_primary_10_15430_JCP_2020_25_1_21 crossref_primary_10_3390_ijms19030830 crossref_primary_10_1186_s13148_019_0782_2 crossref_primary_10_1002_cncr_32068 crossref_primary_10_1158_1078_0432_CCR_18_2024 crossref_primary_10_1111_jop_12236 crossref_primary_10_1158_1078_0432_CCR_13_1050 crossref_primary_10_1136_jitc_2021_002585 crossref_primary_10_1158_1078_0432_CCR_15_2314 crossref_primary_10_1016_j_bbrc_2015_12_006 crossref_primary_10_1038_bjc_2014_521 crossref_primary_10_1007_s12032_017_0884_7 crossref_primary_10_18632_oncotarget_28355 crossref_primary_10_1200_CCI_17_00045 crossref_primary_10_1038_srep12566 crossref_primary_10_1093_carcin_bgu194 crossref_primary_10_1002_ijc_30493 crossref_primary_10_1038_s41419_021_04066_z crossref_primary_10_1002_ijc_31115 crossref_primary_10_1111_odi_12246 crossref_primary_10_1016_j_phymed_2017_12_011 crossref_primary_10_1016_j_canlet_2021_05_025 crossref_primary_10_1016_j_oraloncology_2019_104552 crossref_primary_10_1158_0008_5472_CAN_18_1220 crossref_primary_10_1038_s41388_019_0990_4 crossref_primary_10_3109_00016357_2014_986754 crossref_primary_10_1038_ncomms6835 crossref_primary_10_1038_s41467_024_46785_9 crossref_primary_10_1158_1055_9965_EPI_17_1082 crossref_primary_10_3389_fonc_2019_00827 crossref_primary_10_1016_j_bulcan_2018_05_011 crossref_primary_10_1016_j_jormas_2017_05_004 crossref_primary_10_3727_096368915X688245 crossref_primary_10_1038_cddis_2013_548 crossref_primary_10_1186_s12885_016_2223_3 crossref_primary_10_1186_s13148_017_0386_7 crossref_primary_10_1016_j_redox_2021_102193 crossref_primary_10_1002_hed_25076 crossref_primary_10_1007_s13402_019_00437_z crossref_primary_10_1002_jcp_28084 crossref_primary_10_1016_j_humgen_2023_201183 crossref_primary_10_32948_ajo_2020_10_15 crossref_primary_10_1158_0008_5472_CAN_17_2802 crossref_primary_10_1038_jid_2014_154 crossref_primary_10_1158_1535_7163_MCT_19_1036 crossref_primary_10_5005_jp_journals_10001_1420 crossref_primary_10_1186_s40364_022_00433_w crossref_primary_10_1017_S0022215114002011 crossref_primary_10_3390_app12104926 crossref_primary_10_1089_gtmb_2017_0013 crossref_primary_10_3390_cancers15184563 crossref_primary_10_1016_j_semcancer_2019_09_011 crossref_primary_10_1016_j_jbior_2017_10_006 crossref_primary_10_1111_jcmm_17966 crossref_primary_10_1158_1078_0432_CCR_17_2644 crossref_primary_10_1016_j_canlet_2015_03_006 crossref_primary_10_3389_froh_2021_676643 crossref_primary_10_1016_j_oraloncology_2016_09_010 crossref_primary_10_1007_s12032_019_1336_3 crossref_primary_10_3390_life10100228 crossref_primary_10_18632_oncotarget_8957 crossref_primary_10_1038_s41598_018_24780_7 crossref_primary_10_1158_1940_6207_CAPR_14_0257 crossref_primary_10_3389_fonc_2019_00074 crossref_primary_10_1177_0300891618765558 crossref_primary_10_3390_ijms24032673 crossref_primary_10_1007_s13277_014_2913_x crossref_primary_10_1177_2057178X17702920 crossref_primary_10_1038_s41419_017_0029_0 crossref_primary_10_1016_j_ajoms_2017_06_006 crossref_primary_10_1002_ijc_30068 crossref_primary_10_1158_1940_6207_CAPR_14_0366 crossref_primary_10_3390_genes14081578 crossref_primary_10_7554_eLife_57761 crossref_primary_10_1016_j_soc_2015_03_002 crossref_primary_10_1038_s41379_021_00893_9 crossref_primary_10_1158_1535_7163_MCT_13_1090 crossref_primary_10_1038_bjc_2014_395 crossref_primary_10_1158_1078_0432_CCR_14_0565 crossref_primary_10_1002_cncr_28304 crossref_primary_10_1158_1078_0432_CCR_14_0205 crossref_primary_10_3390_ijms21197073 crossref_primary_10_14694_EdBook_AM_2015_35_e323 crossref_primary_10_22201_fmvz_24486760e_2019_2_495 crossref_primary_10_1038_ng_3051 crossref_primary_10_1177_1758834017746040 crossref_primary_10_3390_ijms20061520 crossref_primary_10_3233_CBM_210275 crossref_primary_10_2217_epi_2020_0348 crossref_primary_10_1186_1471_2407_14_628 crossref_primary_10_3390_cancers13174362 crossref_primary_10_1186_s13039_017_0310_z crossref_primary_10_1136_jitc_2020_001955 crossref_primary_10_1016_j_yexcr_2018_09_019 crossref_primary_10_2217_fon_2016_0168 crossref_primary_10_1158_1078_0432_CCR_17_0721 crossref_primary_10_1038_s42003_022_03675_4 crossref_primary_10_1158_1078_0432_CCR_14_1768 crossref_primary_10_1016_j_cytogfr_2015_03_003 crossref_primary_10_1517_14728222_2015_1012157 crossref_primary_10_1016_j_radonc_2017_06_008 crossref_primary_10_1016_j_ccr_2014_02_018 crossref_primary_10_1200_JCO_2015_62_1086 crossref_primary_10_1016_j_critrevonc_2020_102885 crossref_primary_10_3390_jcm11247259 crossref_primary_10_1002_hed_24593 crossref_primary_10_1038_bjc_2014_372 crossref_primary_10_1002_gcc_22214 crossref_primary_10_1158_1541_7786_MCR_18_0056 crossref_primary_10_3390_cells9122677 crossref_primary_10_1038_ncomms3873 crossref_primary_10_1186_s12864_015_2138_4 crossref_primary_10_1089_omi_2017_0146 crossref_primary_10_1159_000440954 crossref_primary_10_3389_froh_2022_1017276 crossref_primary_10_1080_23723548_2014_954827 crossref_primary_10_18632_oncotarget_4277 crossref_primary_10_1038_onc_2013_417 crossref_primary_10_18632_oncotarget_7543 crossref_primary_10_1007_s10637_020_00898_2 crossref_primary_10_1002_hed_25494 crossref_primary_10_1080_07357907_2019_1635614 crossref_primary_10_1038_onc_2016_1 crossref_primary_10_1002_cncr_28479 crossref_primary_10_1002_jcp_24577 crossref_primary_10_1101_gr_241141_118 crossref_primary_10_1159_000518697 crossref_primary_10_1158_0008_5472_CAN_13_1259 crossref_primary_10_3390_ijms23073478 crossref_primary_10_1016_j_archoralbio_2018_07_018 crossref_primary_10_1007_s12253_018_0462_0 crossref_primary_10_18632_oncotarget_9979 crossref_primary_10_1111_odi_12400 crossref_primary_10_18632_oncotarget_10419 crossref_primary_10_1002_hed_24292 crossref_primary_10_5125_jkaoms_2022_48_1_3 crossref_primary_10_1097_CCO_0000000000000536 crossref_primary_10_1002_lary_27340 crossref_primary_10_1016_j_oor_2024_100370 crossref_primary_10_1016_j_semcancer_2018_01_008 crossref_primary_10_1111_jop_12372 crossref_primary_10_1016_j_molonc_2014_03_018 crossref_primary_10_7717_peerj_6402 crossref_primary_10_1007_s00405_020_05891_2 crossref_primary_10_1517_14728214_2015_1031653 crossref_primary_10_1016_j_oraloncology_2020_104930 crossref_primary_10_18632_oncotarget_8533 crossref_primary_10_3390_ijms19071824 crossref_primary_10_1111_pin_12461 crossref_primary_10_1158_0008_5472_CAN_22_1175 crossref_primary_10_3892_or_2017_5870 crossref_primary_10_1080_17460441_2017_1319356 crossref_primary_10_1038_s41568_018_0024_5 crossref_primary_10_2217_fon_14_18 crossref_primary_10_1245_s10434_014_3818_z crossref_primary_10_1016_j_molonc_2015_05_006 crossref_primary_10_1111_nyas_12599 crossref_primary_10_1016_j_tranon_2023_101669 crossref_primary_10_1111_odi_12309 crossref_primary_10_1038_ncomms10438 crossref_primary_10_1016_j_gendis_2014_07_002 crossref_primary_10_1371_journal_pone_0093102 crossref_primary_10_1016_j_adoms_2021_100021 crossref_primary_10_1007_s13237_017_0212_9 crossref_primary_10_1007_s40496_015_0049_8 crossref_primary_10_1172_jci_insight_139837 crossref_primary_10_1016_j_celrep_2018_07_058 crossref_primary_10_1371_journal_pone_0191701 crossref_primary_10_1038_cddiscovery_2017_22 crossref_primary_10_1016_j_oraloncology_2020_105040 crossref_primary_10_3390_cancers14174151 crossref_primary_10_1016_j_modpat_2023_100190 crossref_primary_10_1038_s41416_018_0364_7 crossref_primary_10_18632_genesandcancer_69 crossref_primary_10_1038_s41467_018_06081_9 crossref_primary_10_1007_s10637_016_0423_y crossref_primary_10_1016_j_oraloncology_2018_06_010 crossref_primary_10_1186_s13073_020_00781_y crossref_primary_10_3390_cancers13143453 crossref_primary_10_1186_s12864_016_3260_7 crossref_primary_10_1186_s41199_016_0004_y crossref_primary_10_1016_j_celrep_2018_10_007 crossref_primary_10_1016_j_critrevonc_2015_03_005 crossref_primary_10_1186_s12957_019_1741_2 crossref_primary_10_1007_s10555_016_9633_1 crossref_primary_10_1073_pnas_1314239110 crossref_primary_10_1016_j_oraloncology_2021_105547 crossref_primary_10_1158_1535_7163_MCT_17_0733 crossref_primary_10_18632_oncotarget_6714 crossref_primary_10_1158_1078_0432_CCR_18_3802 crossref_primary_10_1002_1878_0261_13113 crossref_primary_10_3389_fonc_2021_707066 crossref_primary_10_3390_cancers13123019 crossref_primary_10_1016_j_ebiom_2017_02_025 crossref_primary_10_1038_s41421_019_0126_6 crossref_primary_10_1038_s41598_020_66741_z crossref_primary_10_1158_1541_7786_MCR_18_0445 crossref_primary_10_1002_ijc_34277 crossref_primary_10_2139_ssrn_3293686 crossref_primary_10_1038_onc_2014_169 crossref_primary_10_1016_j_ijrobp_2014_05_045 crossref_primary_10_3390_cancers13205123 crossref_primary_10_1016_j_annonc_2023_09_3102 crossref_primary_10_1158_0008_5472_CAN_15_0199 crossref_primary_10_1186_s41199_016_0003_z crossref_primary_10_1111_aos_14812 crossref_primary_10_1016_j_oraloncology_2015_04_007 crossref_primary_10_1002_ijc_30808 crossref_primary_10_1177_0022034518756352 crossref_primary_10_1186_s41199_019_0045_0 crossref_primary_10_1200_PO_22_00211 crossref_primary_10_3389_pore_2021_641042 crossref_primary_10_1038_onc_2016_71 crossref_primary_10_1007_s00439_019_02083_9 crossref_primary_10_3390_cancers15123227 crossref_primary_10_1016_j_jnutbio_2021_108843 crossref_primary_10_1038_s41467_020_18524_3 crossref_primary_10_1007_s13402_021_00591_3 crossref_primary_10_3390_diagnostics12040951 crossref_primary_10_3390_cells8040333 crossref_primary_10_1038_s41598_019_48229_7 crossref_primary_10_1002_cncr_33309 crossref_primary_10_1007_s13277_016_5439_6 crossref_primary_10_1002_gcc_23076 crossref_primary_10_12998_wjcc_v2_i6_172 crossref_primary_10_3390_cells10010094 crossref_primary_10_1186_s13000_024_01487_0 crossref_primary_10_3324_haematol_2020_247809 crossref_primary_10_3390_cancers13051029 crossref_primary_10_1007_s13402_019_00440_4 crossref_primary_10_1007_s12105_014_0566_0 crossref_primary_10_1016_j_canlet_2020_07_029 crossref_primary_10_3389_fgene_2023_1269084 crossref_primary_10_3389_fimmu_2022_840923 crossref_primary_10_1002_1878_0261_12584 crossref_primary_10_18632_oncotarget_4336 crossref_primary_10_1007_s12105_023_01580_8 crossref_primary_10_1016_j_ctarc_2020_100238 crossref_primary_10_1016_j_canlet_2014_06_003 crossref_primary_10_1158_0008_5472_CAN_14_2735 crossref_primary_10_1038_s42003_023_04828_9 crossref_primary_10_1016_j_oraloncology_2017_07_028 crossref_primary_10_1371_journal_pgen_1005277 crossref_primary_10_1186_s13073_023_01236_w crossref_primary_10_1016_j_ygeno_2017_04_004 crossref_primary_10_3390_jpm8020013 crossref_primary_10_1021_acs_jafc_7b03999 crossref_primary_10_3390_ijms241813755 crossref_primary_10_4155_cli_14_88 crossref_primary_10_1158_1078_0432_CCR_13_2721 crossref_primary_10_1002_1878_0261_12473 crossref_primary_10_1158_1078_0432_CCR_18_0327 crossref_primary_10_1200_JCO_20_02903 crossref_primary_10_1016_j_ccell_2016_12_001 crossref_primary_10_1158_1078_0432_CCR_19_0096 crossref_primary_10_3389_fonc_2019_01379 crossref_primary_10_1002_cam4_382 crossref_primary_10_1038_ng_3757 crossref_primary_10_1111_cge_12487 crossref_primary_10_1007_s00292_014_1918_y crossref_primary_10_1016_j_pharmthera_2018_09_007 crossref_primary_10_2139_ssrn_3925469 |
| Cites_doi | 10.1097/CCO.0b013e3282f9b575 10.1126/science.1208130 10.1038/nature07423 10.1038/nrc2982 10.1158/1078-0432.CCR-11-0046 10.1042/BC20060020 10.1158/0008-5472.CAN-10-3445 10.1128/MCB.23.10.3575-3582.2003 10.1371/journal.pcbi.0010053 10.1182/blood-2011-07-367532 10.1002/ijc.23734 10.1158/0008-5472.CAN-03-2219 10.1073/pnas.1114669108 10.1056/NEJMoa053422 10.1101/gr.092759.109 10.1126/science.1102160 10.1016/j.ceb.2009.07.001 10.1016/j.semradonc.2008.09.009 10.1038/nature11252 10.1056/NEJMoa073770 10.1093/emboj/20.13.3427 10.1038/ng.2538 10.1182/blood-2005-01-0355 10.1016/j.yexcr.2005.03.006 10.1038/nrc2675 10.1073/pnas.0710052104 10.1016/j.ccr.2005.12.013 10.1002/1097-0347(200103)23:3<238::AID-HED1025>3.0.CO;2-H 10.1186/1758-3284-1-32 10.1158/1078-0432.CCR-11-0690 10.1111/j.1600-0714.2005.00343.x 10.1074/jbc.M111.234419 10.1016/j.oraloncology.2008.07.011 10.1038/onc.2008.229 10.1126/science.1206923 10.4161/cc.6.3.3792 10.1242/jcs.02398 10.1002/humu.20495 10.1126/science.1219580 10.1007/s00428-002-0729-3 10.1073/pnas.1009843107 10.1371/journal.pone.0056823 10.1073/pnas.1206062109 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1158/2159-8290.cd-12-0537 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2159-8290 |
| EndPage | 781 |
| ExternalDocumentID | 10_1158_2159_8290_CD_12_0537 23619168 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P30 CA016672 – fundername: NHGRI NIH HHS grantid: U54 HG003273 – fundername: NCI NIH HHS grantid: P30CA0CA16672 – fundername: NCI NIH HHS grantid: P50 CA097007 – fundername: NIDCR NIH HHS grantid: RC2 DE020958 – fundername: NCI NIH HHS grantid: P50CA097007 – fundername: NIDCR NIH HHS grantid: RC2DE020958 |
| GroupedDBID | --- 53G 5VS AAJMC ADBBV ADCOW AENEX AFHIN ALMA_UNASSIGNED_HOLDINGS BR6 BTFSW CGR CUY CVF EBS ECM EIF EJD H13 KQ8 NPM OK1 RCR RHF RHI AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c521t-fdd6ed378b249ae8c594aa8d117bd86edc76ba3904302f9dabedea2599c06c03 |
| ISSN | 2159-8274 |
| IngestDate | Thu Oct 24 22:57:12 EDT 2024 Thu Nov 21 22:35:39 EST 2024 Sat Sep 28 08:04:08 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c521t-fdd6ed378b249ae8c594aa8d117bd86edc76ba3904302f9dabedea2599c06c03 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://cancerdiscovery.aacrjournals.org/content/candisc/3/7/770.full.pdf |
| PMID | 23619168 |
| PQID | 1399931666 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_1399931666 crossref_primary_10_1158_2159_8290_CD_12_0537 pubmed_primary_23619168 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-Jul 2013-07-01 20130701 |
| PublicationDateYYYYMMDD | 2013-07-01 |
| PublicationDate_xml | – month: 07 year: 2013 text: 2013-Jul |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cancer discovery |
| PublicationTitleAlternate | Cancer Discov |
| PublicationYear | 2013 |
| References | 21680732 - J Biol Chem. 2011 Aug 12;286(32):28181-91 18758484 - Oncogene. 2008 Sep 1;27(38):5148-67 16467544 - N Engl J Med. 2006 Feb 9;354(6):567-78 15922730 - Exp Cell Res. 2005 Jul 1;307(1):100-8 16608439 - Biol Cell. 2006 Aug;98(8):479-90 12724416 - Mol Cell Biol. 2003 May;23(10):3575-82 15472075 - Science. 2004 Oct 8;306(5694):269-71 17224652 - Cell Cycle. 2007 Feb 1;6(3):269-73 21617878 - Oncol Rep. 2011 Sep;26(3):587-92 20837533 - Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16910-5 16091111 - J Oral Pathol Med. 2005 Sep;34(8):449-59 18805044 - Oral Oncol. 2009 Apr-May;45(4-5):324-34 15923647 - J Cell Sci. 2005 Jun 1;118(Pt 11):2347-53 22006338 - Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17761-6 16413471 - Cancer Cell. 2006 Jan;9(1):45-56 18077431 - Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20007-12 21160525 - Nat Rev Cancer. 2011 Jan;11(1):9-22 18948947 - Nature. 2008 Oct 23;455(7216):1069-75 16118316 - Blood. 2005 Dec 1;106(12):3898-906 12461610 - Virchows Arch. 2002 Dec;441(6):541-50 19541911 - Genome Res. 2009 Sep;19(9):1639-45 21576089 - Cancer Res. 2011 May 15;71(10):3688-700 22810696 - Nature. 2012 Jul 19;487(7407):330-7 11428456 - Head Neck. 2001 Mar;23(3):238-53 18688849 - Int J Cancer. 2008 Oct 15;123(8):1779-86 16261194 - PLoS Comput Biol. 2005 Oct;1(5):e53 21798893 - Science. 2011 Aug 26;333(6046):1157-60 22343728 - Blood. 2012 Apr 12;119(15):3495-502 22628553 - Science. 2012 Jul 6;337(6090):104-9 18391623 - Curr Opin Oncol. 2008 May;20(3):256-63 19679459 - Curr Opin Cell Biol. 2009 Oct;21(5):717-23 18094376 - N Engl J Med. 2007 Dec 20;357(25):2552-61 21903770 - Clin Cancer Res. 2011 Nov 1;17(21):6658-70 21868764 - Clin Cancer Res. 2011 Dec 1;17(23):7248-64 17311302 - Hum Mutat. 2007 Jun;28(6):622-9 22566646 - Proc Natl Acad Sci U S A. 2012 May 22;109(21):8212-7 19028347 - Semin Radiat Oncol. 2009 Jan;19(1):63-8 23354438 - Nat Genet. 2013 Mar;45(3):253-61 11432830 - EMBO J. 2001 Jul 2;20(13):3427-36 19609265 - Nat Rev Cancer. 2009 Aug;9(8):587-95 23451093 - PLoS One. 2013;8(2):e56823 21798897 - Science. 2011 Aug 26;333(6046):1154-7 15173003 - Cancer Res. 2004 Jun 1;64(11):3922-7 19678942 - Head Neck Oncol. 2009;1:32 Zhao (2022060623320718100_bib15) 2011; 17 Agrawal (2022060623320718100_bib2) 2011; 333 Sano (2022060623320718100_bib14) 2011; 17 Dotto (2022060623320718100_bib19) 2009; 9 Van Loo (2022060623320718100_bib38) 2010; 107 Sano (2022060623320718100_bib44) 2009; 1 Walter (2022060623320718100_bib12) 2013; 8 Harari (2022060623320718100_bib26) 2009; 19 Molinolo (2022060623320718100_bib34) 2009; 45 Hakem (2022060623320718100_bib37) 2012; 119 Bockmuhl (2022060623320718100_bib6) 2002; 441 Rocco (2022060623320718100_bib18) 2006; 9 Poeta (2022060623320718100_bib28) 2007; 357 Bonner (2022060623320718100_bib9) 2006; 354 Nishikawa (2022060623320718100_bib25) 2011; 26 Network TCGA (2022060623320718100_bib13) 2012; 487 Koster (2022060623320718100_bib20) 2007; 6 Leemans (2022060623320718100_bib1) 2011; 11 Wreesmann (2022060623320718100_bib8) 2005; 34 Sadeqzadeh (2022060623320718100_bib33) 2011; 286 Ding (2022060623320718100_bib41) 2008; 455 Le Tourneau (2022060623320718100_bib10) 2008; 20 Duan (2022060623320718100_bib35) 2006; 98 Krzywinski (2022060623320718100_bib40) 2009; 19 Yang (2022060623320718100_bib17) 2011; 71 D'Souza (2022060623320718100_bib16) 2008; 27 Beroukhim (2022060623320718100_bib39) 2007; 104 Morris (2022060623320718100_bib24) 2013; 45 Zweidler-McKay (2022060623320718100_bib43) 2005; 106 Weng (2022060623320718100_bib4) 2004; 306 Solimini (2022060623320718100_bib29) 2012; 337 Nesterov (2022060623320718100_bib36) 2004; 64 Wang (2022060623320718100_bib5) 2011; 108 Ciani (2022060623320718100_bib22) 2003; 23 Tanoue (2022060623320718100_bib32) 2005; 118 Gollin (2022060623320718100_bib7) 2001; 23 Rangarajan (2022060623320718100_bib21) 2001; 20 Stransky (2022060623320718100_bib3) 2011; 333 Petitjean (2022060623320718100_bib27) 2007; 28 Jiang (2022060623320718100_bib11) 2008; 123 Sopko (2022060623320718100_bib23) 2009; 21 Magg (2022060623320718100_bib31) 2005; 307 Zhang (2022060623320718100_bib42) 2005; 1 Xue (2022060623320718100_bib30) 2012; 109 |
| References_xml | – volume: 20 start-page: 256 year: 2008 ident: 2022060623320718100_bib10 article-title: Molecular-targeted therapies in the treatment of squamous cell carcinomas of the head and neck publication-title: Curr Opin Oncol doi: 10.1097/CCO.0b013e3282f9b575 contributor: fullname: Le Tourneau – volume: 333 start-page: 1157 year: 2011 ident: 2022060623320718100_bib3 article-title: The mutational landscape of head and neck squamous cell carcinoma publication-title: Science doi: 10.1126/science.1208130 contributor: fullname: Stransky – volume: 455 start-page: 1069 year: 2008 ident: 2022060623320718100_bib41 article-title: Somatic mutations affect key pathways in lung adenocarcinoma publication-title: Nature doi: 10.1038/nature07423 contributor: fullname: Ding – volume: 11 start-page: 9 year: 2011 ident: 2022060623320718100_bib1 article-title: The molecular biology of head and neck cancer publication-title: Nat Rev Cancer doi: 10.1038/nrc2982 contributor: fullname: Leemans – volume: 17 start-page: 6658 year: 2011 ident: 2022060623320718100_bib14 article-title: Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-11-0046 contributor: fullname: Sano – volume: 98 start-page: 479 year: 2006 ident: 2022060623320718100_bib35 article-title: Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells publication-title: Biol Cell doi: 10.1042/BC20060020 contributor: fullname: Duan – volume: 71 start-page: 3688 year: 2011 ident: 2022060623320718100_bib17 article-title: DeltaNp63 versatilely regulates a Broad NF-kappaB gene program and promotes squamous epithelial proliferation, migration, and inflammation publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-3445 contributor: fullname: Yang – volume: 23 start-page: 3575 year: 2003 ident: 2022060623320718100_bib22 article-title: Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype publication-title: Mol Cell Biol doi: 10.1128/MCB.23.10.3575-3582.2003 contributor: fullname: Ciani – volume: 1 start-page: e53 year: 2005 ident: 2022060623320718100_bib42 article-title: SNPdetector: a software tool for sensitive and accurate SNP detection publication-title: PLoS Comput Biol doi: 10.1371/journal.pcbi.0010053 contributor: fullname: Zhang – volume: 119 start-page: 3495 year: 2012 ident: 2022060623320718100_bib37 article-title: Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis publication-title: Blood doi: 10.1182/blood-2011-07-367532 contributor: fullname: Hakem – volume: 123 start-page: 1779 year: 2008 ident: 2022060623320718100_bib11 article-title: Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma publication-title: Int J Cancer doi: 10.1002/ijc.23734 contributor: fullname: Jiang – volume: 64 start-page: 3922 year: 2004 ident: 2022060623320718100_bib36 article-title: Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-03-2219 contributor: fullname: Nesterov – volume: 108 start-page: 17761 year: 2011 ident: 2022060623320718100_bib5 article-title: Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1114669108 contributor: fullname: Wang – volume: 354 start-page: 567 year: 2006 ident: 2022060623320718100_bib9 article-title: Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck publication-title: N Engl J Med doi: 10.1056/NEJMoa053422 contributor: fullname: Bonner – volume: 19 start-page: 1639 year: 2009 ident: 2022060623320718100_bib40 article-title: Circos: an information aesthetic for comparative genomics publication-title: Genome Res doi: 10.1101/gr.092759.109 contributor: fullname: Krzywinski – volume: 306 start-page: 269 year: 2004 ident: 2022060623320718100_bib4 article-title: Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia publication-title: Science doi: 10.1126/science.1102160 contributor: fullname: Weng – volume: 26 start-page: 587 year: 2011 ident: 2022060623320718100_bib25 article-title: Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of beta-catenin publication-title: Oncol Rep contributor: fullname: Nishikawa – volume: 21 start-page: 717 year: 2009 ident: 2022060623320718100_bib23 article-title: The skinny on Fat: an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2009.07.001 contributor: fullname: Sopko – volume: 19 start-page: 63 year: 2009 ident: 2022060623320718100_bib26 article-title: Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond publication-title: Semin Radiat Oncol doi: 10.1016/j.semradonc.2008.09.009 contributor: fullname: Harari – volume: 487 start-page: 330 year: 2012 ident: 2022060623320718100_bib13 article-title: Comprehensive molecular characterization of human colon and rectal cancer publication-title: Nature doi: 10.1038/nature11252 contributor: fullname: Network TCGA – volume: 357 start-page: 2552 year: 2007 ident: 2022060623320718100_bib28 article-title: TP53 mutations and survival in squamous-cell carcinoma of the head and neck publication-title: N Engl J Med doi: 10.1056/NEJMoa073770 contributor: fullname: Poeta – volume: 20 start-page: 3427 year: 2001 ident: 2022060623320718100_bib21 article-title: Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation publication-title: EMBO J doi: 10.1093/emboj/20.13.3427 contributor: fullname: Rangarajan – volume: 45 start-page: 253 year: 2013 ident: 2022060623320718100_bib24 article-title: Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation publication-title: Nat Genet doi: 10.1038/ng.2538 contributor: fullname: Morris – volume: 106 start-page: 3898 year: 2005 ident: 2022060623320718100_bib43 article-title: Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies publication-title: Blood doi: 10.1182/blood-2005-01-0355 contributor: fullname: Zweidler-McKay – volume: 307 start-page: 100 year: 2005 ident: 2022060623320718100_bib31 article-title: Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2005.03.006 contributor: fullname: Magg – volume: 9 start-page: 587 year: 2009 ident: 2022060623320718100_bib19 article-title: Crosstalk of Notch with p53 and p63 in cancer growth control publication-title: Nat Rev Cancer doi: 10.1038/nrc2675 contributor: fullname: Dotto – volume: 104 start-page: 20007 year: 2007 ident: 2022060623320718100_bib39 article-title: Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0710052104 contributor: fullname: Beroukhim – volume: 9 start-page: 45 year: 2006 ident: 2022060623320718100_bib18 article-title: p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis publication-title: Cancer Cell doi: 10.1016/j.ccr.2005.12.013 contributor: fullname: Rocco – volume: 23 start-page: 238 year: 2001 ident: 2022060623320718100_bib7 article-title: Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease publication-title: Head Neck doi: 10.1002/1097-0347(200103)23:3<238::AID-HED1025>3.0.CO;2-H contributor: fullname: Gollin – volume: 1 start-page: 32 year: 2009 ident: 2022060623320718100_bib44 article-title: Xenograft models of head and neck cancers publication-title: Head Neck Oncol doi: 10.1186/1758-3284-1-32 contributor: fullname: Sano – volume: 17 start-page: 7248 year: 2011 ident: 2022060623320718100_bib15 article-title: Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-11-0690 contributor: fullname: Zhao – volume: 34 start-page: 449 year: 2005 ident: 2022060623320718100_bib8 article-title: Chromosomal aberrations in squamous cell carcinomas of the upper aerodigestive tract: biologic insights and clinical opportunities publication-title: J Oral Pathol Med doi: 10.1111/j.1600-0714.2005.00343.x contributor: fullname: Wreesmann – volume: 286 start-page: 28181 year: 2011 ident: 2022060623320718100_bib33 article-title: Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products publication-title: J Biol Chem doi: 10.1074/jbc.M111.234419 contributor: fullname: Sadeqzadeh – volume: 45 start-page: 324 year: 2009 ident: 2022060623320718100_bib34 article-title: Dysregulated molecular networks in head and neck carcinogenesis publication-title: Oral Oncol doi: 10.1016/j.oraloncology.2008.07.011 contributor: fullname: Molinolo – volume: 27 start-page: 5148 year: 2008 ident: 2022060623320718100_bib16 article-title: The many facets of Notch ligands publication-title: Oncogene doi: 10.1038/onc.2008.229 contributor: fullname: D'Souza – volume: 333 start-page: 1154 year: 2011 ident: 2022060623320718100_bib2 article-title: Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 publication-title: Science doi: 10.1126/science.1206923 contributor: fullname: Agrawal – volume: 6 start-page: 269 year: 2007 ident: 2022060623320718100_bib20 article-title: Conflicting roles for p63 in skin development and carcinogenesis publication-title: Cell Cycle doi: 10.4161/cc.6.3.3792 contributor: fullname: Koster – volume: 118 start-page: 2347 year: 2005 ident: 2022060623320718100_bib32 article-title: New insights into Fat cadherins publication-title: J Cell Sci doi: 10.1242/jcs.02398 contributor: fullname: Tanoue – volume: 28 start-page: 622 year: 2007 ident: 2022060623320718100_bib27 article-title: Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database publication-title: Hum Mutat doi: 10.1002/humu.20495 contributor: fullname: Petitjean – volume: 337 start-page: 104 year: 2012 ident: 2022060623320718100_bib29 article-title: Recurrent hemizygous deletions in cancers may optimize proliferative potential publication-title: Science doi: 10.1126/science.1219580 contributor: fullname: Solimini – volume: 441 start-page: 541 year: 2002 ident: 2022060623320718100_bib6 article-title: DNA ploidy and chromosomal alterations in head and neck squamous cell carcinoma publication-title: Virchows Arch doi: 10.1007/s00428-002-0729-3 contributor: fullname: Bockmuhl – volume: 107 start-page: 16910 year: 2010 ident: 2022060623320718100_bib38 article-title: Allele-specific copy number analysis of tumors publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1009843107 contributor: fullname: Van Loo – volume: 8 start-page: e56823 year: 2013 ident: 2022060623320718100_bib12 article-title: Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes publication-title: PLoS ONE doi: 10.1371/journal.pone.0056823 contributor: fullname: Walter – volume: 109 start-page: 8212 year: 2012 ident: 2022060623320718100_bib30 article-title: A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1206062109 contributor: fullname: Xue |
| SSID | ssj0000494507 |
| Score | 2.594294 |
| Snippet | The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to... |
| SourceID | proquest crossref pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 770 |
| SubjectTerms | Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Caspase 8 - genetics Caspase 8 - metabolism Cell Line, Tumor DNA Copy Number Variations - genetics DNA Methylation - genetics Gene Expression Regulation, Neoplastic - genetics Genomics Humans Mouth Neoplasms - genetics Mouth Neoplasms - pathology Point Mutation - genetics Receptors, Notch - genetics Receptors, Notch - metabolism |
| Title | Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23619168 https://search.proquest.com/docview/1399931666 |
| Volume | 3 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3di9QwEA96gvgifrvnBxF8Kz2327RJH2VVztMThRXureRTi9i92-2C3F_vTJqmVe9AfSmlYVM682N2ZjLzG0KeK265K4VOXcFMyuxCpZXkJdxlbu60Fbmf3nD8oTz8zI5OipMxmeO7Szp1oM8v7Cv5H63CM9Ardsn-g2bjpvAA7kG_cAUNw_WvdPw2cD1g9Q-SrWKdu44MzOfRG_Rd-NuzncQ4P8FcPTJS6wZ-IZPG9AVDdpu4jS-s7pLtumdyNRtftjH1YJcIkw0e7Gis_owZ-Y8NFmiECSnLHQ55HosRY1r6qLE_mnY0Neu-Muhb4q1OzA3Y9ku3Db1g73E6mJxmJ3BSBB-yE9ZbMXApqhRPa6cmN58gi0_MJ--HiPxp1gtsVYhbHWjjK0qKni9mounT717VyCgDfq8Y_-Ri6eGwdJVcQ-5EHLfw7pOIaTmkywEXOTRZwntfXPRWpJAO-_zqz1wSpHhnZXWL3AxRBn3ZQ-Y2uWLbO-T6caijuEu-TpBDA3Lo78iha0cROXRADkXk0IgcOiKHDsihATk0IOceWb15vVoepmHmRqpxtEXqjCmtyblQEJdLK3RRMSmFyTKujIAlzUsl8wqp4hauMlJZYyXE0JWel3qe3yd77bq1DwmVTIIzqJgFAwBCZQKMgcsksyWbL5TSM5IOgqtPe2aV2kekhahR5jXKvF6-qrNFjTKfkWeDdGswgfjFsrXw8TUEMeBl4_n3jDzoxR53HNS0f-nKI3JjBO5jstdtdvYJOJqdeuqh8RNz4IFo |
| link.rule.ids | 314,780,784,27924,27925 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Integrative+genomic+characterization+of+oral+squamous+cell+carcinoma+identifies+frequent+somatic+drivers&rft.jtitle=Cancer+discovery&rft.au=Pickering%2C+Curtis+R&rft.au=Zhang%2C+Jiexin&rft.au=Yoo%2C+Suk+Young&rft.au=Bengtsson%2C+Linnea&rft.date=2013-07-01&rft.eissn=2159-8290&rft.volume=3&rft.issue=7&rft.spage=770&rft_id=info:doi/10.1158%2F2159-8290.cd-12-0537&rft_id=info%3Apmid%2F23619168&rft.externalDocID=23619168 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2159-8274&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2159-8274&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2159-8274&client=summon |