Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression — a dual-isotope SPECT study
Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients...
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| Published in | Psychiatry research. Neuroimaging Vol. 184; no. 3; pp. 157 - 161 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ireland Ltd
30.12.2010
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| Abstract | Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [
123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [
99mTc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression. |
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| AbstractList | Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [
123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [
99mTc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression. Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [ super(123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [) super(9)9mTc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression. Abstract Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [123 I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99m Tc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression. Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [(123)I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [(99m)Tc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression.Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [(123)I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [(99m)Tc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression. Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [(123)I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [(99m)Tc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression. |
| Author | Lee, I Hui Yeh, Tzung Lieh Chiu, Nan Tsing Chen, Kao Chin Chen, Po See Yang, Yen Kuang Yao, Wei Jen Hsieh, Pei Chun Lu, Ru-Band Huang, Hui Chun |
| Author_xml | – sequence: 1 givenname: Pei Chun surname: Hsieh fullname: Hsieh, Pei Chun organization: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan – sequence: 2 givenname: I Hui surname: Lee fullname: Lee, I Hui organization: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan – sequence: 3 givenname: Tzung Lieh surname: Yeh fullname: Yeh, Tzung Lieh organization: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan – sequence: 4 givenname: Kao Chin surname: Chen fullname: Chen, Kao Chin organization: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan – sequence: 5 givenname: Hui Chun surname: Huang fullname: Huang, Hui Chun organization: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan – sequence: 6 givenname: Po See surname: Chen fullname: Chen, Po See organization: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan – sequence: 7 givenname: Yen Kuang surname: Yang fullname: Yang, Yen Kuang email: ykyang@mail.ncku.edu.tw organization: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan – sequence: 8 givenname: Wei Jen surname: Yao fullname: Yao, Wei Jen organization: Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan – sequence: 9 givenname: Ru-Band surname: Lu fullname: Lu, Ru-Band organization: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan – sequence: 10 givenname: Nan Tsing surname: Chiu fullname: Chiu, Nan Tsing organization: Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan |
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| Keywords | Dopamine transporter Serotonin transporter Major depression Single photon emission computed tomography Euthymic state |
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| Snippet | Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with... Abstract Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison... |
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| SubjectTerms | Adult Brain - diagnostic imaging Brain - metabolism Brain Mapping Case-Control Studies Cinanserin - analogs & derivatives Depressive Disorder, Major - classification Depressive Disorder, Major - diagnostic imaging Depressive Disorder, Major - metabolism Depressive Disorder, Major - pathology Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter Euthymic state Female Humans Major depression Male Middle Aged Organotechnetium Compounds Psychiatric Status Rating Scales Psychiatry Radiology Radiopharmaceuticals Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin transporter Single photon emission computed tomography Tomography, Emission-Computed, Single-Photon - methods Tropanes |
| Title | Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression — a dual-isotope SPECT study |
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