The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo

• Published in: Cell Vol. 161; no. 2; pp. 319 - 332
• Main Authors: Karreth, Florian A., Reschke, Markus, Ruocco, Anna, Ng, Christopher, Chapuy, Bjoern, Léopold, Valentine, Sjoberg, Marcela, Keane, Thomas M., Verma, Akanksha, Ala, Ugo, Tay, Yvonne, Wu, David, Seitzer, Nina, Velasco-Herrera, Martin Del Castillo, Bothmer, Anne, Fung, Jacqueline, Langellotto, Fernanda, Rodig, Scott J., Elemento, Olivier, Shipp, Margaret A., Adams, David J., Chiarle, Roberto, Pandolfi, Pier Paolo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.04.2015
• Subjects: Animals; Base Sequence; Humans; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Large B-Cell, Diffuse - metabolism; Mice; Molecular Sequence Data; Proto-Oncogene Proteins B-raf - genetics; Proto-Oncogene Proteins B-raf - metabolism; Pseudogenes; RNA - metabolism

Research over the past decade has suggested important roles for pseudogenes in physiology and disease. In vitro experiments demonstrated that pseudogenes contribute to cell transformation through several mechanisms. However, in vivo evidence for a causal role of pseudogenes in cancer development is...