The heterogeneity among subgroups of haplogroup J influencing Alzheimer’s disease risk
[Display omitted] •There is heterogeneity among subgroups of haplogroup J which influences AD risk.•The heterogeneity among haplogroup J influences the MCI-to-AD conversion risk.•The heterogeneity among subgroups of haplogroup J is independent of Aβ and p-tau. The impact of mitochondrial haplogroups...
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| Published in | Journal of advanced research Vol. 33; pp. 117 - 126 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Egypt
Elsevier B.V
01.11.2021
Elsevier |
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| Abstract | [Display omitted]
•There is heterogeneity among subgroups of haplogroup J which influences AD risk.•The heterogeneity among haplogroup J influences the MCI-to-AD conversion risk.•The heterogeneity among subgroups of haplogroup J is independent of Aβ and p-tau.
The impact of mitochondrial haplogroups on Alzheimer’s disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level.
The aim of this research is to evaluate the association between mitochondrial haplogroups and AD risk in subgroups level.
In total, 809 AD Neuroimaging Initiative subjects were assessed using mtDNA sequencing, the AD Assessment Scale-Cognitive Subscale (ADAS-cog), hippocampal volume measurements, the hypometabolic convergence index (HCI), and MCI-to-AD conversion proportion measurements.
The frequency of haplogroup J was significantly higher than that of other haplogroups in the AD group (p = 0.013). According to the correlation between haplogroup J-specific SNPs and ADAS-cog, haplogroup J was divided into four subgroups harboring exacerbating SNPs, protective SNPs, both exacerbating and protective SNPs, or irrelevant SNPs. The subgroups harboring exacerbating SNPs exhibited higher AD risk represented by the levels of ADAS-cog, hippocampal volume, HCI, and MCI-to-AD conversion proportion than other subgroups.
Heterogeneity existed among the subgroups of haplogroup J, which suggested that different subgroups exhibited different levels of AD risk. This study provides novel insights into the correlation between mitochondrial haplogroups and AD risk. |
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| AbstractList | Introduction: The impact of mitochondrial haplogroups on Alzheimer’s disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level. Objectives: The aim of this research is to evaluate the association between mitochondrial haplogroups and AD risk in subgroups level. Methods: In total, 809 AD Neuroimaging Initiative subjects were assessed using mtDNA sequencing, the AD Assessment Scale-Cognitive Subscale (ADAS-cog), hippocampal volume measurements, the hypometabolic convergence index (HCI), and MCI-to-AD conversion proportion measurements. Results: The frequency of haplogroup J was significantly higher than that of other haplogroups in the AD group (p = 0.013). According to the correlation between haplogroup J-specific SNPs and ADAS-cog, haplogroup J was divided into four subgroups harboring exacerbating SNPs, protective SNPs, both exacerbating and protective SNPs, or irrelevant SNPs. The subgroups harboring exacerbating SNPs exhibited higher AD risk represented by the levels of ADAS-cog, hippocampal volume, HCI, and MCI-to-AD conversion proportion than other subgroups. Conclusion: Heterogeneity existed among the subgroups of haplogroup J, which suggested that different subgroups exhibited different levels of AD risk. This study provides novel insights into the correlation between mitochondrial haplogroups and AD risk. • There is heterogeneity among subgroups of haplogroup J which influences AD risk. • The heterogeneity among haplogroup J influences the MCI-to-AD conversion risk. • The heterogeneity among subgroups of haplogroup J is independent of Aβ and p-tau. The impact of mitochondrial haplogroups on Alzheimer's disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level. The aim of this research is to evaluate the association between mitochondrial haplogroups and AD risk in subgroups level. In total, 809 AD Neuroimaging Initiative subjects were assessed using mtDNA sequencing, the AD Assessment Scale-Cognitive Subscale (ADAS-cog), hippocampal volume measurements, the hypometabolic convergence index (HCI), and MCI-to-AD conversion proportion measurements. The frequency of haplogroup J was significantly higher than that of other haplogroups in the AD group (p = 0.013). According to the correlation between haplogroup J-specific SNPs and ADAS-cog, haplogroup J was divided into four subgroups harboring exacerbating SNPs, protective SNPs, both exacerbating and protective SNPs, or irrelevant SNPs. The subgroups harboring exacerbating SNPs exhibited higher AD risk represented by the levels of ADAS-cog, hippocampal volume, HCI, and MCI-to-AD conversion proportion than other subgroups. Heterogeneity existed among the subgroups of haplogroup J, which suggested that different subgroups exhibited different levels of AD risk. This study provides novel insights into the correlation between mitochondrial haplogroups and AD risk. The impact of mitochondrial haplogroups on Alzheimer's disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level.IntroductionThe impact of mitochondrial haplogroups on Alzheimer's disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level.The aim of this research is to evaluate the association between mitochondrial haplogroups and AD risk in subgroups level.ObjectivesThe aim of this research is to evaluate the association between mitochondrial haplogroups and AD risk in subgroups level.In total, 809 AD Neuroimaging Initiative subjects were assessed using mtDNA sequencing, the AD Assessment Scale-Cognitive Subscale (ADAS-cog), hippocampal volume measurements, the hypometabolic convergence index (HCI), and MCI-to-AD conversion proportion measurements.MethodsIn total, 809 AD Neuroimaging Initiative subjects were assessed using mtDNA sequencing, the AD Assessment Scale-Cognitive Subscale (ADAS-cog), hippocampal volume measurements, the hypometabolic convergence index (HCI), and MCI-to-AD conversion proportion measurements.The frequency of haplogroup J was significantly higher than that of other haplogroups in the AD group (p = 0.013). According to the correlation between haplogroup J-specific SNPs and ADAS-cog, haplogroup J was divided into four subgroups harboring exacerbating SNPs, protective SNPs, both exacerbating and protective SNPs, or irrelevant SNPs. The subgroups harboring exacerbating SNPs exhibited higher AD risk represented by the levels of ADAS-cog, hippocampal volume, HCI, and MCI-to-AD conversion proportion than other subgroups.ResultsThe frequency of haplogroup J was significantly higher than that of other haplogroups in the AD group (p = 0.013). According to the correlation between haplogroup J-specific SNPs and ADAS-cog, haplogroup J was divided into four subgroups harboring exacerbating SNPs, protective SNPs, both exacerbating and protective SNPs, or irrelevant SNPs. The subgroups harboring exacerbating SNPs exhibited higher AD risk represented by the levels of ADAS-cog, hippocampal volume, HCI, and MCI-to-AD conversion proportion than other subgroups.Heterogeneity existed among the subgroups of haplogroup J, which suggested that different subgroups exhibited different levels of AD risk. This study provides novel insights into the correlation between mitochondrial haplogroups and AD risk.ConclusionHeterogeneity existed among the subgroups of haplogroup J, which suggested that different subgroups exhibited different levels of AD risk. This study provides novel insights into the correlation between mitochondrial haplogroups and AD risk. [Display omitted] •There is heterogeneity among subgroups of haplogroup J which influences AD risk.•The heterogeneity among haplogroup J influences the MCI-to-AD conversion risk.•The heterogeneity among subgroups of haplogroup J is independent of Aβ and p-tau. The impact of mitochondrial haplogroups on Alzheimer’s disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level. The aim of this research is to evaluate the association between mitochondrial haplogroups and AD risk in subgroups level. In total, 809 AD Neuroimaging Initiative subjects were assessed using mtDNA sequencing, the AD Assessment Scale-Cognitive Subscale (ADAS-cog), hippocampal volume measurements, the hypometabolic convergence index (HCI), and MCI-to-AD conversion proportion measurements. The frequency of haplogroup J was significantly higher than that of other haplogroups in the AD group (p = 0.013). According to the correlation between haplogroup J-specific SNPs and ADAS-cog, haplogroup J was divided into four subgroups harboring exacerbating SNPs, protective SNPs, both exacerbating and protective SNPs, or irrelevant SNPs. The subgroups harboring exacerbating SNPs exhibited higher AD risk represented by the levels of ADAS-cog, hippocampal volume, HCI, and MCI-to-AD conversion proportion than other subgroups. Heterogeneity existed among the subgroups of haplogroup J, which suggested that different subgroups exhibited different levels of AD risk. This study provides novel insights into the correlation between mitochondrial haplogroups and AD risk. |
| Author | Zhao, Huimin Liu, XiaoQuan Du, Yanan Liu, HaoChen Zhang, Yixuan |
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| CitedBy_id | crossref_primary_10_1016_j_mito_2022_06_008 crossref_primary_10_3390_genes13101789 crossref_primary_10_1002_alz_13449 crossref_primary_10_1111_acel_13601 crossref_primary_10_3233_JAD_220298 |
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| Copyright | 2021 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 2021 |
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| Keywords | Heterogeneity Subgroup Alzheimer’s disease risk Mitochondrial haplogroups |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf. |
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•There is heterogeneity among subgroups of haplogroup J which influences AD risk.•The heterogeneity among haplogroup J influences the... The impact of mitochondrial haplogroups on Alzheimer's disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup... • There is heterogeneity among subgroups of haplogroup J which influences AD risk. • The heterogeneity among haplogroup J influences the MCI-to-AD conversion... Introduction: The impact of mitochondrial haplogroups on Alzheimer’s disease (AD) risk has not been fully elucidated and warrants further investigation at the... |
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| StartPage | 117 |
| SubjectTerms | Alzheimer Disease - genetics Alzheimer’s disease risk DNA, Mitochondrial - genetics Heterogeneity Humans Medicine Mitochondrial haplogroups Polymorphism, Single Nucleotide - genetics Subgroup |
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| Title | The heterogeneity among subgroups of haplogroup J influencing Alzheimer’s disease risk |
| URI | https://dx.doi.org/10.1016/j.jare.2021.02.003 https://www.ncbi.nlm.nih.gov/pubmed/34603783 https://www.proquest.com/docview/2579092603 https://pubmed.ncbi.nlm.nih.gov/PMC8463963 https://doaj.org/article/54abd4cd84a74639a4f61ca8309b85b4 |
| Volume | 33 |
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