Serum C-reactive protein level on first postoperative day can predict occurrence of postoperative pancreatic fistula after laparoscopic gastrectomy

Purpose : Postoperative pancreatic fistula (POPF) is a serious complication after gastrectomy for gastric cancer. The purpose of this study is to identify the risk factor of POPF and evaluate C-reactive protein on postoperative day 1 (POD1) as the predictor for POPF after laparoscopic gastrectomy (L...

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Published inThe Journal of Medical Investigation Vol. 66; no. 3.4; pp. 285 - 288
Main Authors Yamada, Shinichiro, Yagi, Shigehiko, Sato, Koichi, Shin’e, Mikiya, Sakamoto, Akimasa, Utsunomiya, Daichi, Okikawa, Shohei, Aibara, Norimasa, Watanabe, Miya, Obatake, Masayoshi, Ono, Riki, Fujii, Masahiko, Otani, Hiromi, Kawasaki, Hideki
Format Journal Article
LanguageEnglish
Published The University of Tokushima Faculty of Medicine 01.01.2019
Subjects
C-reactive protein
laparoscopic gastrectomy
postoperative pancreatic fistula
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Abstract Purpose : Postoperative pancreatic fistula (POPF) is a serious complication after gastrectomy for gastric cancer. The purpose of this study is to identify the risk factor of POPF and evaluate C-reactive protein on postoperative day 1 (POD1) as the predictor for POPF after laparoscopic gastrectomy (LG). Methods : Between May 2013 and September 2016, 226 patients who underwent LG for gastric cancer were investigated. Patients were divided into 2 groups; POPF group (n = 17) and control group (n = 209). Clinicopathological factors were compared between 2 groups. Results : In POPF group, there are more male patients (p = 0.003) compared with control group. Preoperative factors, such as age, BMI, and prevalence of previous operation and comorbidity showed no significant difference between 2 groups. Regarding tumor factors and perioperative data such as blood loss and operative time, there were also no significant difference between 2 groups. POPF group showed longer postoperative hospital stay, and higher serum CRP level on POD1 (p < 0.0001). Multivariate analysis revealed that high CRP level on POD1 ( ≥ 3mg/dl) was independent risk factor of POPF. Conclusions : High serum CRP level on POD1 can predict the occurrence of POPF. J. Med. Invest. 66 : 285-288, August, 2019
AbstractList Purpose : Postoperative pancreatic fistula (POPF) is a serious complication after gastrectomy for gastric cancer. The purpose of this study is to identify the risk factor of POPF and evaluate C-reactive protein on postoperative day 1 (POD1) as the predictor for POPF after laparoscopic gastrectomy (LG). Methods : Between May 2013 and September 2016, 226 patients who underwent LG for gastric cancer were investigated. Patients were divided into 2 groups; POPF group (n = 17) and control group (n = 209). Clinicopathological factors were compared between 2 groups. Results : In POPF group, there are more male patients (p = 0.003) compared with control group. Preoperative factors, such as age, BMI, and prevalence of previous operation and comorbidity showed no significant difference between 2 groups. Regarding tumor factors and perioperative data such as blood loss and operative time, there were also no significant difference between 2 groups. POPF group showed longer postoperative hospital stay, and higher serum CRP level on POD1 (p < 0.0001). Multivariate analysis revealed that high CRP level on POD1 ( ≥ 3mg/dl) was independent risk factor of POPF. Conclusions : High serum CRP level on POD1 can predict the occurrence of POPF. J. Med. Invest. 66 : 285-288, August, 2019
Author Sakamoto, Akimasa
Kawasaki, Hideki
Fujii, Masahiko
Yagi, Shigehiko
Utsunomiya, Daichi
Obatake, Masayoshi
Watanabe, Miya
Sato, Koichi
Ono, Riki
Yamada, Shinichiro
Otani, Hiromi
Shin’e, Mikiya
Aibara, Norimasa
Okikawa, Shohei
Author_xml – sequence: 1
  fullname: Yamada, Shinichiro
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
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  fullname: Yagi, Shigehiko
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
– sequence: 3
  fullname: Sato, Koichi
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
– sequence: 4
  fullname: Shin’e, Mikiya
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
– sequence: 5
  fullname: Sakamoto, Akimasa
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
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  fullname: Utsunomiya, Daichi
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
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  fullname: Okikawa, Shohei
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
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  fullname: Aibara, Norimasa
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
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  fullname: Watanabe, Miya
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
– sequence: 10
  fullname: Obatake, Masayoshi
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
– sequence: 11
  fullname: Ono, Riki
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
– sequence: 12
  fullname: Fujii, Masahiko
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
– sequence: 13
  fullname: Otani, Hiromi
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
– sequence: 14
  fullname: Kawasaki, Hideki
  organization: Departments of Gastrointestinal Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan
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CitedBy_id crossref_primary_10_1371_journal_pone_0239709
crossref_primary_10_5230_jgc_2021_21_e3
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Snippet Purpose : Postoperative pancreatic fistula (POPF) is a serious complication after gastrectomy for gastric cancer. The purpose of this study is to identify the...
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SubjectTerms C-reactive protein
laparoscopic gastrectomy
postoperative pancreatic fistula
Title Serum C-reactive protein level on first postoperative day can predict occurrence of postoperative pancreatic fistula after laparoscopic gastrectomy
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